PDB Search results for query - Protein Data Bank Japan

PDB: 69 results

Retrofitting antibodies with stabilizing mutations. Herceptin scFv mutant.
Descriptor:	Human Variable Heavy Chain of Herceptin, Human Variable Light Chain of Herceptin
Authors:	Langley, D.B, Roome, B, Christ, D.
Deposit date:	2014-12-04
Release date:	2015-12-23
Last modified:	2020-01-08
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Retrofitting antibodies with stabilizing mutations To Be Published

7MSQ

Complex between the Fab arm of AB-3467 and the SARS-CoV-2 receptor binding domain (RBD)
Descriptor:	AB-3467 Fab Heavy Chain, AB-3467 Fab Light Chain, CHLORIDE ION, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2021-05-12
Release date:	2022-01-19
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.29 Å)
Cite:	Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability. Immunity, 54, 2021

4X4Z

Retrofitting antibodies with stabilizing mutations. Herceptin VL mutant F53D.
Descriptor:	Herceptin VL domain with F53D mutation
Authors:	Langley, D.B, Rouet, R, Christ, D.
Deposit date:	2014-12-04
Release date:	2015-12-23
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Retrofitting antibodies with stabilizing mutations To Be Published

1DUV

CRYSTAL STRUCTURE OF E. COLI ORNITHINE TRANSCARBAMOYLASE COMPLEXED WITH NDELTA-L-ORNITHINE-DIAMINOPHOSPHINYL-N-SULPHONIC ACID (PSORN)
Descriptor:	(4S)-2-METHYL-2,4-PENTANEDIOL, NDELTA-(N'-SULPHODIAMINOPHOSPHINYL)-L-ORNITHINE, ORNITHINE TRANSCARBAMOYLASE
Authors:	Langley, D.B, Templeton, M.D, Fields, B.A, Mitchell, R.E, Collyer, C.A.
Deposit date:	2000-01-18
Release date:	2000-07-04
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Mechanism of inactivation of ornithine transcarbamoylase by Ndelta -(N'-Sulfodiaminophosphinyl)-L-ornithine, a true transition state analogue? Crystal structure and implications for catalytic mechanism. J.Biol.Chem., 275, 2000

2ZCG

Structure and inhibition of orotidine 5'-phosphate decarboxylase from plasmodium falciparum
Descriptor:	Orotidine 5'-phosphate decarboxylase
Authors:	Langley, D.B, Guss, J.M, Shojaei, M, Christopherson, R.I.
Deposit date:	2007-11-08
Release date:	2008-03-11
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (2.223 Å)
Cite:	Structure and Inhibition of Orotidine 5'-Monophosphate Decarboxylase from Plasmodium falciparum Biochemistry, 47, 2008

2ZP2

C-terminal domain of KipI from Bacillus subtilis
Descriptor:	Kinase A inhibitor
Authors:	Langley, D.B, Jacques, D.A.
Deposit date:	2008-06-24
Release date:	2009-01-20
Last modified:	2023-11-01
Method:	X-RAY DIFFRACTION (3.01 Å)
Cite:	Histidine kinase regulation by a cyclophilin-like inhibitor J.Mol.Biol., 384, 2008

7RTA

Crystal structures of human PYY and NPY
Descriptor:	4A3B2-B Fab heavy chain, 4A3B2-B Fab light chain, Neuropeptide Y, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2021-08-12
Release date:	2022-03-02
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY). Neuropeptides, 92, 2022

7RT9

Crystal structures of human PYY and NPY
Descriptor:	4A3B2-A Fab heavy chain, 4A3B2-A Fab light chain, GLYCEROL, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2021-08-12
Release date:	2022-03-02
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal structures of human neuropeptide Y (NPY) and peptide YY (PYY). Neuropeptides, 92, 2022

7T72

Epitope-based selection of SARS-CoV-2 neutralizing antibodies from convalescent patients
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody heavy chain, Antibody light chain, ...
Authors:	Langley, D.B, Christ, D, Rouet, R.
Deposit date:	2021-12-14
Release date:	2022-12-21
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (3.177 Å)
Cite:	Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients. Nat Commun, 14, 2023

7UEN

Genetic and structural basis of the human anti-alpha-galactosyl antibody response
Descriptor:	M86 antibody Fab heavy chain, M86 antibody Fab light chain, PHOSPHATE ION, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2022-03-22
Release date:	2022-06-29
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Genetic and structural basis of the human anti-alpha-galactosyl antibody response. Proc.Natl.Acad.Sci.USA, 119, 2022

7UEM

Genomic and structural basis for the human anti-alpha-galactosyl antibody response
Descriptor:	CHLORIDE ION, Heavy chain Fab arm of antibody HKB7, Light chain Fab of antibody HKB7, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2022-03-22
Release date:	2022-06-29
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.314 Å)
Cite:	Genetic and structural basis of the human anti-alpha-galactosyl antibody response. Proc.Natl.Acad.Sci.USA, 119, 2022

7UEL

Genetic and structural basis for the human anti-alpha-galactosyl antibody response
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Heavy chain Fab of antibody JEC1, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2022-03-22
Release date:	2022-06-29
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Genetic and structural basis of the human anti-alpha-galactosyl antibody response. Proc.Natl.Acad.Sci.USA, 119, 2022

7KZB

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Fab heavy chain of CR3014-C8 antibody, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2020-12-10
Release date:	2021-02-03
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.83 Å)
Cite:	Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies. Mabs, 13

7KZC

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies
Descriptor:	CHLORIDE ION, Fab heavy chain of m396-B10 antibody, Fab light chain of m396-B10 antibody
Authors:	Langley, D.B, Christ, D.
Deposit date:	2020-12-10
Release date:	2021-02-24
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies. Mabs, 13

7KZA

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1antibodies
Descriptor:	CHLORIDE ION, Fab fragment heavy chain of anti-CoV2-RBD antibody variant CR3022-B6, Fab fragment light chain of anti-CoV2-RBD antibody variant CR3022-B6, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2020-12-10
Release date:	2021-02-24
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.69 Å)
Cite:	Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies. Mabs, 13

8CWK

Fab arm of antibodies 4G1-C2 and 10G4 bound to CoV-2 receptor binding domain (RBD)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Heavy chain of Fab arm of antibody 10G4, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2022-05-19
Release date:	2023-05-24
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.368 Å)
Cite:	Neutralization of CoV-2 omicron sublineages by affinity-matured class 5 antibodies To Be Published

8CWI

Fab arm of antibody 10G4 bound to CoV-2 receptor binding domain (RBD)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Heavy chain of Fab arm of antibody 10G4, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2022-05-19
Release date:	2023-05-24
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.873 Å)
Cite:	Neutralization of CoV-2 omicron lineages by affinity-matured class 5 antibodies To Be Published

8CWJ

Fab arms of antibodies 4C12-B12 and CR3022 bound to pangolin receptor binding domain (pRBD)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2022-05-19
Release date:	2023-05-24
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.449 Å)
Cite:	Neutralization of CoV-2 omicron lineages by affinity-matured class 5 antibodies To Be Published

8DXT

Fab arm of antibody GAR12 bound to the receptor binding domain of SARS-CoV-2.
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab arm of antibody GAR12, Light chain of Fab arm of antibody GAR12, ...
Authors:	Langley, D.B, Christ, D, Henry, J.Y.
Deposit date:	2022-08-03
Release date:	2023-01-18
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients. Nat Commun, 14, 2023

8DXU

Fab arms of antibodies GAR03 and 10G4 bound to the receptor binding domain of SARS-CoV-2 in a 1:1:1 complex.
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Heavy chain of Fab arm of antibody 10G4, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2022-08-03
Release date:	2023-01-18
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.728 Å)
Cite:	Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients. Nat Commun, 14, 2023

6D9I

Pekin duck egg lysozyme isoform II (DEL-II)
Descriptor:	CHLORIDE ION, Lysozyme, MAGNESIUM ION
Authors:	Langley, D.B, Christ, D.
Deposit date:	2018-04-30
Release date:	2018-09-05
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.15 Å)
Cite:	Crystal structure of duck egg lysozyme isoform II (DEL-II). BMC Struct. Biol., 18, 2018

6DSI

Anti recombinant prolactin receptor scFv
Descriptor:	Anti-TN-C scFv
Authors:	Langley, D.B, Rouet, R, Christ, D.
Deposit date:	2018-06-14
Release date:	2019-06-19
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.49 Å)
Cite:	Anti recombinant prolactin receptor scFv To Be Published

6DN0

Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D.
Descriptor:	FORMIC ACID, Human Variable Heavy Chain of Herceptin containing VH mutation K30D, Human Variable Light Chain of Herceptin containing VL mutation S52D
Authors:	Langley, D.B, Roome, B, Christ, D.
Deposit date:	2018-06-05
Release date:	2019-06-12
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Retrofitting antibodies with stabilizing mutations To Be Published

6P4B

HyHEL10 fab variant HyHEL10-4x (heavy chain mutations L4F, Y33H, S56N, and Y58F) bound to hen egg lysozyme variant HEL2x-flex (mutations R21Q, R73E, C76S, and C94S)
Descriptor:	CHLORIDE ION, HyHEL10 Fab heavy chain, HyHEL10 Fab light chain, ...
Authors:	Langley, D.B, Christ, D.
Deposit date:	2019-05-27
Release date:	2020-05-27
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117, 2020

6P4C

HyHEL10 Fab carrying four heavy chain mutations (HyHEL10-4x): L4F, Y33H, S56N, and Y58F
Descriptor:	CHLORIDE ION, HyHEL10 Fab heavy chain, HyHEL10 Fab light chain
Authors:	Langley, D.B, Christ, D.
Deposit date:	2019-05-27
Release date:	2020-05-27
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Conformational diversity facilitates antibody mutation trajectories and discrimination between foreign and self-antigens. Proc.Natl.Acad.Sci.USA, 117, 2020

12 3 >

Total results:	69
Displayed results:	25
Sorted by:	Hit score (from highest)
Deposition authors:	"Langley, D.B."