Author results

4CGL
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LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE IN COMPLEX WITH AN AMINOACYLPYRROLIDINE INHIBITOR
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, (3R)-3-azanyl-4-(4-chlorophenyl)-1-[(3S,4R)-3-(4-chlorophenyl)-4-(hydroxymethyl)pyrrolidin-1-yl]butan-1-one, ...
Authors:Brannigan, J.A., Roberts, S.M., Bell, A.S., Hutton, J.A., Smith, D.F., Tate, E.W., Leatherbarrow, R.J., Wilkinson, A.J.
Deposit date:2013-11-25
Release date:2014-07-09
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Diverse Modes of Binding in Structures of Leishmania Major N-Myristoyltransferase with Selective Inhibitors
Iucrj, 1, 2014
4CGN
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LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A PIPERIDINYLINDOLE INHIBITOR
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, 2-(4-fluorophenyl)-N-(3-piperidin-4-yl-1H-indol-5-yl)ethanamide, ...
Authors:Brannigan, J.A., Roberts, S.M., Bell, A.S., Hutton, J.A., Smith, D.F., Tate, E.W., Leatherbarrow, R.J., Wilkinson, A.J.
Deposit date:2013-11-25
Release date:2014-07-09
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Diverse Modes of Binding in Structures of Leishmania Major N-Myristoyltransferase with Selective Inhibitors
Iucrj, 1, 2014
1DQD
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CRYSTAL STRUCTURE OF FAB HGR-2 F6, A COMPETITIVE ANTAGONIST OF THE GLUCAGON RECEPTOR
Descriptor:FAB HGR-2 F6
Authors:Wright, L.M., Brzozowski, A.M., Hubbard, R.E., Pike, A.C.W., Roberts, S.M., Skovgaard, R.N., Svendsen, I., Vissing, H., Bywater, R.P.
Deposit date:2000-01-04
Release date:2000-05-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptor.
Acta Crystallogr.,Sect.D, 56, 2000
1GYD
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STRUCTURE OF CELLVIBRIO CELLULOSA ALPHA-L-ARABINANASE
Descriptor:ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A
Authors:Nurizzo, D., Turkenburg, J.P., Charnock, S.J., Roberts, S.M., Dodson, E.J., McKie, V.A., Taylor, E.J., Gilbert, H.J., Davies, G.J.
Deposit date:2002-04-23
Release date:2002-08-23
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold.
Nat. Struct. Biol., 9, 2002
1GYE
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STRUCTURE OF CELLVIBRIO CELLULOSA ALPHA-L-ARABINANASE COMPLEXED WITH ARABINOHEXAOSE
Descriptor:ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A, ALPHA-L-ARABINOFURANOSE, CHLORIDE ION
Authors:Nurizzo, D., Turkenburg, J.P., Charnock, S.J., Roberts, S.M., Dodson, E.J., McKie, V.A., Taylor, E.J., Gilbert, H.J., Davies, G.J.
Deposit date:2002-04-23
Release date:2002-08-23
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold.
Nat. Struct. Biol., 9, 2002
1GYH
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STRUCTURE OF D158A CELLVIBRIO CELLULOSA ALPHA-L-ARABINANASE MUTANT
Descriptor:ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A, CHLORIDE ION
Authors:Nurizzo, D., Turkenburg, J.P., Charnock, S.J., Roberts, S.M., Dodson, E.J., McKie, V.A., Taylor, E.J., Gilbert, H.J., Davies, G.J.
Deposit date:2002-04-23
Release date:2002-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Cellovibrio Cellulosa Alpha-L-Arabinanase 43A Has a Novel Five-Blade Beta-Propeller Fold
Nat.Struct.Biol., 9, 2002
1QFK
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STRUCTURE OF HUMAN FACTOR VIIA AND ITS IMPLICATIONS FOR THE TRIGGERING OF BLOOD COAGULATION
Descriptor:COAGULATION FACTOR VIIA LIGHT CHAIN, COAGULATION FACTOR VIIA HEAVY CHAIN, ALPHA-D-GLUCOSE, ...
Authors:Pike, A.C.W., Brzozowski, A.M., Roberts, S.M., Olsen, O.H., Persson, E.
Deposit date:1999-04-12
Release date:1999-08-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of human factor VIIa and its implications for the triggering of blood coagulation.
Proc.Natl.Acad.Sci.USA, 96, 1999
1UZ9
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CRYSTALLOGRAPHIC AND SOLUTION STUDIES OF N-LITHOCHOLYL INSULIN: A NEW GENERATION OF PROLONGED-ACTING INSULINS.
Descriptor:INSULIN, M-CRESOL, (2S)-2-AMINO-6-({(4R)-4-[(10R,13S)-10,13-DIMETHYL-3-OXOHEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOYL}AMINO)HEXANOIC ACID, ...
Authors:Whittingham, J.L., Jonassen, I., Havelund, S., Roberts, S.M., Dodson, E.J., Verma, C.S., Wilkinson, A.J., Dodson, G.G.
Deposit date:2004-03-08
Release date:2005-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic and Solution Studies of N-Lithocholyl Insulin: A New Generation of Prolonged-Acting Human Insulins
Biochemistry, 43, 2004
2IYA
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THE CRYSTAL STRUCTURE OF MACROLIDE GLYCOSYLTRANSFERASES: A BLUEPRINT FOR ANTIBIOTIC ENGINEERING
Descriptor:OLEANDOMYCIN GLYCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-14-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}-1,9-DIOXASPIRO[2.13]HEXADEC-12-YL 2,6-DIDEOXY-3-O-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSIDE
Authors:Bolam, D.N., Roberts, S.M., Proctor, M.R., Turkenburg, J.P., Dodson, E.J., Martinez-Fleites, C., Yang, M., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2006-07-13
Release date:2007-03-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity.
Proc.Natl.Acad.Sci.USA, 104, 2007
2IYF
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THE CRYSTAL STRUCTURE OF MACROLIDE GLYCOSYLTRANSFERASES: A BLUEPRINT FOR ANTIBIOTIC ENGINEERING
Descriptor:OLEANDOMYCIN GLYCOSYLTRANSFERASE, ERYTHROMYCIN A, URIDINE-5'-DIPHOSPHATE, ...
Authors:Bolam, D.N., Roberts, S.M., Proctor, M.R., Turkenburg, J.P., Dodson, E.J., Martinez-Fleites, C., Yang, M., Davis, B.G., Davies, G.J., Gilbert, H.J.
Deposit date:2006-07-17
Release date:2007-03-27
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity.
Proc.Natl.Acad.Sci.USA, 104, 2007
2WHJ
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UNDERSTANDING HOW DIVERSE MANNANASES RECOGNISE HETEROGENEOUS SUBSTRATES
Descriptor:BETA-MANNANASE, GLYCEROL, ACETATE ION, ...
Authors:Tailford, L.E., Ducros, V.M.A., Flint, J.E., Roberts, S.M., Morland, C., Zechel, D.L., Smith, N., Bjornvad, M.E., Borchert, T.V., Wilson, K.S., Davies, G.J., Gilbert, H.J.
Deposit date:2009-05-05
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Understanding How Diverse -Mannanases Recognise Heterogeneous Substrates.
Biochemistry, 48, 2009
2WHL
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UNDERSTANDING HOW DIVERSE MANNANASES RECOGNISE HETEROGENEOUS SUBSTRATES
Descriptor:BETA-MANNANASE, ACETATE ION, ALPHA-D-MANNOSE, ...
Authors:Tailford, L.E., Ducros, V.M.A., Flint, J.E., Roberts, S.M., Morland, C., Zechel, D.L., Smith, N., Bjornvad, M.E., Borchert, T.V., Wilson, K.S., Davies, G.J., Gilbert, H.J.
Deposit date:2009-05-05
Release date:2009-05-26
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Understanding How Diverse -Mannanases Recognise Heterogeneous Substrates.
Biochemistry, 48, 2009
2WYN
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STRUCTURE OF FAMILY 37 TREHALASE FROM ESCHERICHIA COLI IN COMPLEX WITH A CASUARINE-6-O-A-D-GLUCOSIDE ANALOGUE
Descriptor:PERIPLASMIC TREHALASE, (1R,2R,3R,6R,7R,7AR)-3,7-BIS(HYDROXYMETHYL)HEXAHYDRO-1H-PYRROLIZINE-1,2,6-TRIOL, ALPHA-D-GLUCOSE, ...
Authors:Gloster, T.M., Roberts, S.M., Davies, G.J., Cardona, F., Goti, A., Parmeggiani, C., Parenti, P., Fusi, P., Forcella, M., Cipolla, L.
Deposit date:2009-11-17
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Casuarine-6-O-Alpha-D-Glucoside and its Analogues are Tight Binding Inhibitors of Insect and Bacterial Trehalases.
Chem.Commun.(Camb.), 46, 2010
2XFD
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VCBM60 IN COMPLEX WITH CELLOBIOSE
Descriptor:CARBOHYDRATE BINDING MODULE, CALCIUM ION, CELLOBIOSE, ...
Authors:Montanier, C., Flint, J.E., Bolam, D.N., Xie, H., Liu, Z., Rogowski, A., Weiner, D.P., Nurizzo, D., Roberts, S.M., Turkenburg, J.P., Davies, G.J., Gilbert, H.J.
Deposit date:2010-05-21
Release date:2010-06-16
Last modified:2012-08-15
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Circular Permutation Provides an Evolutionary Link between Two Families of Calcium-Dependent Carbohydrate Binding Modules.
J.Biol.Chem., 285, 2010
2XFE
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VCBM60 IN COMPLEX WITH GALACTOBIOSE
Descriptor:CARBOHYDRATE BINDING MODULE, BETA-D-GALACTOSE, CALCIUM ION
Authors:Montanier, C., Flint, J.E., Bolam, D.N., Xie, H., Liu, Z., Rogowski, A., Weiner, D.P., Nurizzo, D., Roberts, S.M., Turkenburg, J.P., Davies, G.J., Gilbert, H.J.
Deposit date:2010-05-21
Release date:2010-06-16
Last modified:2012-08-15
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Circular Permutation Provides an Evolutionary Link between Two Families of Calcium-Dependent Carbohydrate Binding Modules.
J.Biol.Chem., 285, 2010
2XHH
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CIRCULAR PERMUTATION PROVIDES AN EVOLUTIONARY LINK BETWEEN TWO FAMILIES OF CALCIUM-DEPENDENT CARBOHYDRATE BINDING MODULES
Descriptor:CARBOHYDRATE BINDING MODULE, (2S)-2-hydroxybutanedioic acid, CALCIUM ION
Authors:Montanier, C., Flint, J.E., Bolam, D.N., Xie, H., Liu, Z., Rogowski, A., Weiner, D., Ratnaparkhe, S., Nurizzo, D., Roberts, S.M., Turkenburg, J.P., Davies, G.J., Gilbert, H.J.
Deposit date:2010-06-16
Release date:2010-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Circular Permutation Provides an Evolutionary Link between Two Families of Calcium-Dependent Carbohydrate Binding Modules
J.Biol.Chem., 285, 2010
2XHJ
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CIRCULAR PERMUTATION PROVIDES AN EVOLUTIONARY LINK BETWEEN TWO FAMILIES OF CALCIUM-DEPENDENT CARBOHYDRATE BINDING MODULES. SEMET FORM OF VCBM60.
Descriptor:CALCIUM-DEPENDENT CARBOHYDRATE BINDING MODULE, CALCIUM ION
Authors:Montanier, C., Flint, J.E., Bolam, D.N., Xie, H., Liu, Z., Rogowski, A., Weiner, D., Ratnaparkhe, S., Nurizzo, D., Roberts, S.M., Turkenburg, J.P., Davies, G.J., Gilbert, H.J.
Deposit date:2010-06-16
Release date:2010-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Circular Permutation Provides an Evolutionary Link between Two Families of Calcium-Dependent Carbohydrate Binding Modules
J.Biol.Chem., 285, 2010
2YIH
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STRUCTURE OF A PAENIBACILLUS POLYMYXA XYLOGLUCANASE FROM GH FAMILY 44 WITH XYLOGLUCAN
Descriptor:CEL44C, CALCIUM ION, CHLORIDE ION, ...
Authors:Ariza, A., Eklof, J.M., Spadiut, O., Offen, W.A., Roberts, S.M., Besenmatter, W., Friis, E.P., Skjot, M., Wilson, K.S., Brumer, H., Davies, G.
Deposit date:2011-05-13
Release date:2011-06-08
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and Activity of Paenibacillus Polymyxa Xyloglucanase from Glycoside Hydrolase Family 44.
J.Biol.Chem., 286, 2011
2YJQ
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STRUCTURE OF A PAENIBACILLUS POLYMYXA XYLOGLUCANASE FROM GLYCOSIDE HYDROLASE FAMILY 44
Descriptor:CEL44C, TETRAHYDROOXAZINE, BETA-D-GLUCOSE, ...
Authors:Ariza, A., Eklof, J.M., Spadiut, O., Offen, W.A., Roberts, S.M., Besenmatter, W., Friis, E.P., Skjot, M., Wilson, K.S., Brumer, H., Davies, G.
Deposit date:2011-05-23
Release date:2011-06-15
Last modified:2012-04-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure and Activity of Paenibacillus Polymyxa Xyloglucanase from Glycoside Hydrolase Family 44.
J.Biol.Chem., 286, 2011
2YKK
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STRUCTURE OF A PAENIBACILLUS POLYMYXA XYLOGLUCANASE FROM GLYCOSIDE HYDROLASE FAMILY 44
Descriptor:CEL44C, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ...
Authors:Ariza, A., Eklof, J.M., Spadiut, O., Offen, W.A., Roberts, S.M., Besenmatter, W., Friis, E.P., Skjot, M., Wilson, K.S., Brumer, H., Davies, G.
Deposit date:2011-05-27
Release date:2011-06-22
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure and Activity of Paenibacillus Polymyxa Xyloglucanase from Glycoside Hydrolase Family 44.
J.Biol.Chem., 286, 2011
3T60
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, 2',5'-dideoxy-5'-(tritylamino)uridine, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-28
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
3T64
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, 5'-(BENZHYDRYLAMINO)-2',5'-DIDEOXYURIDINE, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-28
Release date:2012-08-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
3T6Y
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, peptide ALA-HIS-ALA, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-29
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
3T70
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5'-DIPHENYL NUCLEOSIDE INHIBITORS OF PLASMODIUM FALCIPARUM DUTPASE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative, PEPTIDE GLY-HIS-GLY, ...
Authors:Hampton, S.E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Musso-Buendia, A., Recio, E., Kaiser, M., Whittingham, J.L., Roberts, S.M., Shevtsov, M., Brannigan, J.A., Kahnberg, P., Brun, R., Wilson, K.S., Gonzalez-Pacanowska, D., Johansson, N.G., Gilbert, I.H.
Deposit date:2011-07-29
Release date:2012-08-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Chemmedchem, 6, 2011
3ZQ9
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STRUCTURE OF A PAENIBACILLUS POLYMYXA XYLOGLUCANASE FROM GLYCOSIDE HYDROLASE FAMILY 44
Descriptor:XYLOGLUCANASE, (2R,3S,4R,5R)-5-(HYDROXYMETHYL)PIPERIDINE-2,3,4-TRIOL, BETA-D-GLUCOSE, ...
Authors:Ariza, A., Eklof, J.M., Spadiut, O., Offen, W.A., Roberts, S.M., Besenmatter, W., Friis, E.P., Skjot, M., Wilson, K.S., Brumer, H., Davies, G.
Deposit date:2011-06-08
Release date:2011-06-22
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure and Activity of Paenibacillus Polymyxa Xyloglucanase from Glycoside Hydrolase Family 44.
J.Biol.Chem., 286, 2011
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