4CYQ
Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 45).
Summary for 4CYQ
Entry DOI | 10.2210/pdb4cyq/pdb |
Related | 4CYN 4CYO 4CYP |
Descriptor | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, N-{2-chloro-5-[(3S,4R)-1-[(3R)-4-(4-chlorophenyl)-3-hydroxybutanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]phenyl}-2-(4-fluorophenyl)acetamide, ... (5 entities in total) |
Functional Keywords | transferase, myristoylation, drug design, inhibitor |
Biological source | LEISHMANIA MAJOR |
Total number of polymer chains | 1 |
Total formula weight | 49071.78 |
Authors | Hutton, J.A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Waugh, T.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. (deposition date: 2014-04-14, release date: 2014-10-01, Last modification date: 2024-05-08) |
Primary citation | Hutton, J.A.,Goncalves, V.,Brannigan, J.A.,Paape, D.,Wright, M.H.,Waugh, T.M.,Roberts, S.M.,Bell, A.S.,Wilkinson, A.J.,Smith, D.F.,Leatherbarrow, R.J.,Tate, E.W. Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors. J.Med.Chem., 57:8664-, 2014 Cited by PubMed: 25238611DOI: 10.1021/JM5011397 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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