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6HMS
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BU of 6hms by Molmil
Cryo-EM map of DNA polymerase D from Pyrococcus abyssi in complex with DNA
Descriptor: DNA (5'-D(*GP*AP*GP*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*TP*GP*AP*CP*GP*CP*GP*GP*CP*CP*CP*GP*TP*CP*TP*C)-3'), DNA polymerase II large subunit,DNA polymerase II large subunit, ...
Authors:Raia, P, Carroni, M, Sauguet, L.
Deposit date:2018-09-12
Release date:2019-01-30
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (7.1 Å)
Cite:Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases.
PLoS Biol., 17, 2019
6HMF
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BU of 6hmf by Molmil
D-family DNA polymerase - DP1 subunit (3'-5' proof-reading exonuclease) H451 proof-reading deficient variant
Descriptor: ACETATE ION, CACODYLATE ION, CALCIUM ION, ...
Authors:Raia, P, Delarue, M, Sauguet, L.
Deposit date:2018-09-12
Release date:2019-01-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases.
PLoS Biol., 17, 2019
2PIS
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BU of 2pis by Molmil
Efforts toward Expansion of the Genetic Alphabet: Structure and Replication of Unnatural Base Pairs
Descriptor: DNA (5'-D(*CP*GP*(CBR)P*GP*AP*AP*(FFD)P*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Matsuda, S, Fillo, J.D, Henry, A.A, Wilkins, S.J, Rai, P, Dwyer, T.J, Geierstanger, B.H, Wemmer, D.E, Schultz, P.G, Spraggon, G, Romesberg, F.E.
Deposit date:2007-04-13
Release date:2007-10-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs.
J.Am.Chem.Soc., 129, 2007
6T8H
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BU of 6t8h by Molmil
Cryo-EM structure of the DNA-bound PolD-PCNA processive complex from P. abyssi
Descriptor: DNA polymerase II small subunit, DNA polymerase sliding clamp, DNA primer, ...
Authors:Madru, C, Raia, P, Hugonneau Beaufet, I, Pehau-Arnaudet, G, England, P, Lindhal, E, Delarue, M, Carroni, M, Sauguet, L.
Deposit date:2019-10-24
Release date:2020-03-04
Last modified:2020-04-08
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.
Nat Commun, 11, 2020
7NJ0
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BU of 7nj0 by Molmil
CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex
Descriptor: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1, G2/mitotic-specific cyclin-B1,G2/mitotic-specific cyclin-B1, ...
Authors:Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A.
Deposit date:2021-02-14
Release date:2021-08-04
Last modified:2021-08-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Nature, 596, 2021
7NJ1
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BU of 7nj1 by Molmil
CryoEM structure of the human Separase-Securin complex
Descriptor: Securin, Separin
Authors:Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A.
Deposit date:2021-02-14
Release date:2021-08-04
Last modified:2021-08-18
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of human separase regulation by securin and CDK1-cyclin B1.
Nature, 596, 2021
6T7Y
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BU of 6t7y by Molmil
Structure of PCNA bound to cPIP motif of DP2 from P. abyssi
Descriptor: DNA polymerase sliding clamp, cPIP motif from the DP2 large subunit of PolD
Authors:Madru, C, Raia, P, Hugonneau Beaufet, I, Delarue, M, Carroni, M, Sauguet, L.
Deposit date:2019-10-23
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.
Nat Commun, 11, 2020
6T7X
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BU of 6t7x by Molmil
Crystal structure of PCNA from P. abyssi
Descriptor: DNA polymerase sliding clamp
Authors:Madru, C, Raia, P, Hugonneau Beaufet, I, Delarue, M, Carroni, M, Sauguet, L.
Deposit date:2019-10-23
Release date:2020-03-04
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.
Nat Commun, 11, 2020
7ZJJ
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BU of 7zjj by Molmil
CspZ (BbCRASP-2) from Borrelia burgdorferi strain B379
Descriptor: CspZ, NITRATE ION
Authors:Brangulis, K, Marcinkiewicz, A, Hart, T.M, Dupuis, A.P, Zamba Campero, M, Nowak, T.A, Stout, J.L, Akopjana, I, Kazaks, A, Bogans, J, Ciota, A.T, Kraiczy, P, Kolokotronis, S.O, Lin, Y.-P.
Deposit date:2022-04-11
Release date:2023-04-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural evolution of an immune evasion determinant shapes pathogen host tropism.
Proc.Natl.Acad.Sci.USA, 120, 2023
7ZJM
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BU of 7zjm by Molmil
Crystal structure of a complex between CspZ from Borrelia burgdorferi strain B408 and human FH SCR domains 6-7
Descriptor: Complement factor H, CspZ, DI(HYDROXYETHYL)ETHER, ...
Authors:Brangulis, K, Marcinkiewicz, A, Hart, T.M, Dupuis, A.P, Zamba Campero, M, Nowak, T.A, Stout, J.L, Akopjana, I, Kazaks, A, Bogans, J, Ciota, A.T, Kraiczy, P, Kolokotronis, S.O, Lin, Y.-P.
Deposit date:2022-04-11
Release date:2023-04-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural evolution of an immune evasion determinant shapes pathogen host tropism.
Proc.Natl.Acad.Sci.USA, 120, 2023
7ZJK
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BU of 7zjk by Molmil
CspZ (BbCRASP-2) from Borrelia burgdorferi strain B408
Descriptor: CspZ
Authors:Brangulis, K, Marcinkiewicz, A, Hart, T.M, Dupuis, A.P, Zamba Campero, M, Nowak, T.A, Stout, J.L, Akopjana, I, Kazaks, A, Bogans, J, Ciota, A.T, Kraiczy, P, Kolokotronis, S.O, Lin, Y.-P.
Deposit date:2022-04-11
Release date:2023-04-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural evolution of an immune evasion determinant shapes pathogen host tropism.
Proc.Natl.Acad.Sci.USA, 120, 2023
8V8K
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BU of 8v8k by Molmil
Crystal Structure of Nanobody NbE
Descriptor: Nanobody NbE
Authors:Koehl, A, Manglik, A, Yu, J, Kumar, A, Zhang, X, Martin, C, Raia, P, Steyaert, J, Ballet, S, Boland, A, Stoeber, M.
Deposit date:2023-12-05
Release date:2024-09-11
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Basis of mu-Opioid Receptor-Targeting by a Nanobody Antagonist
To Be Published
5IHE
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BU of 5ihe by Molmil
D-family DNA polymerase - DP1 subunit (3'-5' proof-reading exonuclease)
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, ACETATE ION, ...
Authors:Sauguet, L, Raia, P, De Larue, M.
Deposit date:2016-02-29
Release date:2016-08-31
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.
Nat Commun, 7, 2016
5IJL
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BU of 5ijl by Molmil
D-family DNA polymerase - DP2 subunit (catalytic subunit)
Descriptor: DNA polymerase II large subunit, ZINC ION
Authors:Sauguet, L, Raia, P, De Larue, M.
Deposit date:2016-03-02
Release date:2016-08-31
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.
Nat Commun, 7, 2016
4BF3
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BU of 4bf3 by Molmil
ErpC, a member of the complement regulator acquiring family of surface proteins from Borrelia burgdorfei, possesses an architecture previously unseen in this protein family.
Descriptor: 1,2-ETHANEDIOL, ERPC
Authors:Caesar, J.J.E, Johnson, S, Kraiczy, P, Lea, S.M.
Deposit date:2013-03-14
Release date:2013-06-05
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Erpc, a Member of the Complement Regulator-Acquiring Family of Surface Proteins from Borrelia Burgdorferi, Possesses an Architecture Previously Unseen in This Protein Family.
Acta Crystallogr.,Sect.F, 69, 2013
4BL4
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BU of 4bl4 by Molmil
Further structural insights into the binding of complement factor H by complement regulator acquiring surface protein 1, CspA (BbCRASP-1), of Borrelia burgdorferi.
Descriptor: COMPLEMENT REGULATOR-ACQUIRING SURFACE PROTEIN 1 (CRASP-1)
Authors:Caesar, J.J.E, Wallich, R, Kraiczy, P, Zipfel, P.F, Lea, S.M.
Deposit date:2013-05-01
Release date:2013-06-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (4.06 Å)
Cite:Further Structural Insights Into the Binding of Complement Factor H by Complement Regulator-Acquiring Surface Protein 1 (CspA) of Borrelia Burgdorferi.
Acta Crystallogr.,Sect.F, 69, 2013
8QOT
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BU of 8qot by Molmil
Structure of the mu opioid receptor bound to the antagonist nanobody NbE
Descriptor: Anti-Fab Nanobody, Mu-type opioid receptor, NabFab HC, ...
Authors:Yu, J, Kumar, A, Zhang, X, Martin, C, Raia, P, Manglik, A, Ballet, S, Boland, A, Stoeber, M.
Deposit date:2023-09-29
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural Basis of mu-Opioid Receptor-Targeting by a Nanobody Antagonist.
Biorxiv, 2023
1W33
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BU of 1w33 by Molmil
BbCRASP-1 from Borrelia Burgdorferi
Descriptor: BBCRASP-1, GLYCEROL
Authors:Cordes, F.S, Roversi, P, Goodstadt, L, Ponting, C, Kraiczy, P, Skerka, C, Kirschfink, M, Simon, M.M, Brade, V, Zipfel, P, Wallich, R, Lea, S.M.
Deposit date:2004-07-13
Release date:2005-02-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Novel Fold for the Factor H-Binding Protein Bbcrasp-1 of Borrelia Burgdorferi
Nat.Struct.Mol.Biol., 12, 2005
1W3Z
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BU of 1w3z by Molmil
SeMet derivative of BbCRASP-1 from Borrelia Burgdorferi
Descriptor: BBCRASP-1
Authors:Cordes, F.S, Roversi, P, Goodstadt, L, Ponting, C, Kraiczy, P, Skerka, C, Kirschfink, M, Simon, M.M, Brade, V, Zipfel, P, Wallich, R, Lea, S.M.
Deposit date:2004-07-21
Release date:2005-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Novel Fold for the Factor H-Binding Protein Bbcrasp-1 of Borrelia Burgdorferi
Nat.Struct.Mol.Biol., 12, 2005
8HNJ
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BU of 8hnj by Molmil
Domain-stabilized glutamine-binding protein
Descriptor: GLUTAMINE, Glutamine ABC transporter, periplasmic glutamine-binding protein GlnH
Authors:Choi, S.H, Park, J.H, Seo, M.H, Park, K.W, Lee, W.K.
Deposit date:2022-12-08
Release date:2023-07-19
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Domain-wise dissection of thermal stability enhancement in multidomain proteins.
Int.J.Biol.Macromol., 237, 2023
4U4S
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BU of 4u4s by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM25 at 1.90 A resolution.
Descriptor: 4-ethyl-3,4-dihydro-2H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide, ACETATE ION, CHLORIDE ION, ...
Authors:Noerholm, A.B, Deva, T, Frydenvang, K, Kastrup, J.S.
Deposit date:2014-07-24
Release date:2014-11-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides.
J.Med.Chem., 57, 2014
4U4X
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BU of 4u4x by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM37 at 1.56 A resolution.
Descriptor: 4-ethyl-3,4-dihydro-2H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Noerholm, A.B, Frydenvang, K, Kastrup, J.S.
Deposit date:2014-07-24
Release date:2014-11-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides.
J.Med.Chem., 57, 2014
5BUU
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BU of 5buu by Molmil
Crystal structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM-321 at 2.07 A resolution
Descriptor: (3R)-7-chloro-2,3,4-trimethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, 1,2-ETHANEDIOL, GLUTAMIC ACID, ...
Authors:Larsen, A.P, Tapken, D, Frydenvang, K, Kastrup, J.S.
Deposit date:2015-06-04
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.
Acs Chem Neurosci, 7, 2016
5ELV
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BU of 5elv by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504-N775) in complex with glutamate and BPAM-521 at 1.92 A resolution
Descriptor: 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, CHLORIDE ION, ...
Authors:Krintel, C, Juknaite, L, Frydenvang, K, Kastrup, J.S.
Deposit date:2015-11-05
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2.
Biophys.J., 110, 2016
6FMH
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BU of 6fmh by Molmil
Crystal structure of the membrane attack complex assembly inhibitor BGA71 from Lyme disease agent Borreliella bavariensis (Native data)
Descriptor: membrane attack complex assembly inhibitor BGA71
Authors:Brangulis, K, Akopjana, I, Petrovskis, I, Kazaks, A, Tars, K.
Deposit date:2018-01-31
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the membrane attack complex assembly inhibitor BGA71 from the Lyme disease agent Borrelia bavariensis.
Sci Rep, 8, 2018

 

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