Author results

1AH6
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STRUCTURE OF THE TETRAGONAL FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90
Authors:Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:1997-04-14
Release date:1997-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1AH8
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STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90, GLYCEROL
Authors:Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:1997-04-14
Release date:1997-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1A4H
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STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE IN COMPLEX WITH GELDANAMYCIN
Descriptor:HEAT SHOCK PROTEIN 90, GELDANAMYCIN
Authors:Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:1998-01-29
Release date:1998-08-05
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
1AM1
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ATP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90, ADENOSINE-5'-DIPHOSPHATE
Authors:Pearl, L.H., Roe, S.M., Prodromou, C.
Deposit date:1997-06-20
Release date:1998-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
1AMW
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ADP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90, ADENOSINE-5'-DIPHOSPHATE
Authors:Pearl, L.H., Roe, S.M., Prodromou, C.
Deposit date:1997-06-19
Release date:1998-06-24
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
2WEP
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YEAST HSP90 N-TERMINAL DOMAIN LI-IV MUTANT WITH ADP
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, ADENOSINE-5'-DIPHOSPHATE
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2009-04-01
Release date:2009-04-14
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90.
Acs Chem.Biol., 4, 2009
2WEQ
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YEAST HSP90 N-TERMINAL DOMAIN LI-IV MUTANT WITH GELDANAMYCIN
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GELDANAMYCIN, GLYCEROL
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2009-04-01
Release date:2009-04-14
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90
Acs Chem.Biol., 4, 2009
2WER
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YEAST HSP90 N-TERMINAL DOMAIN LI-IV MUTANT WITH RADICICOL
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, RADICICOL
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2009-04-01
Release date:2009-04-14
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90.
Acs Chem.Biol., 4, 2009
1BGQ
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RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90, RADICICOL
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:1998-05-29
Release date:1999-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
J.Med.Chem., 42, 1999
1HK7
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MIDDLE DOMAIN OF HSP90
Descriptor:HEAT SHOCK PROTEIN HSP82, CADMIUM ION, MAGNESIUM ION
Authors:Meyer, P., Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:2003-03-06
Release date:2004-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and Functional Analysis of the Middle Segment of Hsp90. Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions
Mol.Cell, 11, 2003
2CG9
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CRYSTAL STRUCTURE OF AN HSP90-SBA1 CLOSED CHAPERONE COMPLEX
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, CO-CHAPERONE PROTEIN SBA1, ADENOSINE-5'-TRIPHOSPHATE
Authors:Ali, M.M.U., Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2006-03-01
Release date:2006-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of an Hsp90-Nucleotide-P23/Sba1 Closed Chaperone Complex
Nature, 440, 2006
2CGE
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CRYSTAL STRUCTURE OF AN HSP90-SBA1 CLOSED CHAPERONE COMPLEX
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Ali, M.M.U., Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2006-03-01
Release date:2006-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of an Hsp90-Nucleotide-P23/Sba1 Closed Chaperone Complex
Nature, 440, 2006
2YGA
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E88G-N92L MUTANT OF N-TERM HSP90 COMPLEXED WITH GELDANAMYCIN
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, GELDANAMYCIN
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2011-04-12
Release date:2011-11-16
Last modified:2013-02-06
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Features of the Streptomyces Hygroscopicus Htpg Reveal How Partial Geldanamycin Resistance Can Arise with Mutation to the ATP Binding Pocket of a Eukaryotic Hsp90.
Faseb J., 25, 2011
4ASA
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THE STRUCTURE OF MODIFIED BENZOQUINONE ANSAMYCINS BOUND TO YEAST N- TERMINAL HSP90
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, [(3R,5S,6R,7R,12E)-5,11-dimethoxy-3,7,9,15,19-pentamethyl-6-oxidanyl-16,20,22-tris(oxidanylidene)-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate, CHLORIDE ION
Authors:Roe, S.M., Prodromou, C.
Deposit date:2012-04-30
Release date:2013-04-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Synthesis of 19-Substituted Geldanamycins with Altered Conformations and Their Binding to Heat Shock Protein Hsp90.
Nat.Chem., 5, 2013
4ASG
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THE STRUCTURE OF MODIFIED BENZOQUINONE ANSAMYCINS BOUND TO YEAST N- TERMINAL HSP90
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, [(3R,5S,6R,7R,11S,12Z,14E)-5,11,21-trimethoxy-3,7,9,15-tetramethyl-6-oxidanyl-16,20,22-tris(oxidanylidene)-19-phenyl-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate, NICKEL (II) ION
Authors:Roe, S.M., Prodromou, C.
Deposit date:2012-05-01
Release date:2013-04-03
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Synthesis of 19-Substituted Geldanamycins with Altered Conformations and Their Binding to Heat Shock Protein Hsp90.
Nat.Chem., 5, 2013
2BRC
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STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90.
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL
Authors:Roe, S.M., Pearl, L.H., Prodromou, C.
Deposit date:2005-05-04
Release date:2005-09-29
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.
Bioorg. Med. Chem. Lett., 15, 2005
2BRE
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STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90.
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL
Authors:Roe, S.M., Pearl, L.H., Prodromou, C.
Deposit date:2005-05-04
Release date:2005-09-29
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.
Bioorg. Med. Chem. Lett., 15, 2005
2CGF
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A RADICICOL ANALOGUE BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE
Authors:Roe, S.M., Prodromou, C., Pearl, L.H., Moody, C.J.
Deposit date:2006-03-02
Release date:2006-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.
Chem.Biol., 13, 2006
2IWS
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RADICICOL ANALOGUES BOUND TO THE ATP SITE OF HSP90
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2006-07-04
Release date:2006-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.
Chem.Biol., 13, 2006
2IWU
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ANALOGUES OF RADICICOL BOUND TO THE ATP-BINDING SITE OF HSP90
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2006-07-04
Release date:2006-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.
Chem.Biol., 13, 2006
2IWX
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ANALOGUES OF RADICICOL BOUND TO THE ATP-BINDING SITE OF HSP90.
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2006-07-05
Release date:2006-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.
Chem.Biol., 13, 2006
2UWD
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INHIBITION OF THE HSP90 MOLECULAR CHAPERONE IN VITRO AND IN VIVO BY NOVEL, SYNTHETIC, POTENT RESORCINYLIC PYRAZOLE, ISOXAZOLE AMIDE ANALOGS
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, MAGNESIUM ION, SULFATE ION, ...
Authors:Sharp, S.Y., Prodromou, C., Boxall, K., Powers, M.V., Holmes, J.L., Box, G., Matthews, T.P., Cheung, K.M., Kalusa, A., James, K., Hayes, A., Hardcastle, A., Dymock, B., Brough, P.A., Barril, X., Cansfield, J.E., Wright, L.M., Surgenor, A., Foloppe, N., Aherne, W., Pearl, L., Jones, K., McDonald, E., Raynaud, F., Eccles, S., Drysdale, M., Workman, P.
Deposit date:2007-03-20
Release date:2007-04-24
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Mol. Cancer Ther., 6, 2007
2VCI
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4,5 DIARYL ISOXAZOLE HSP90 CHAPERONE INHIBITORS: POTENTIAL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-[2,4-DIHYDROXY-5-(1-METHYLETHYL)PHENYL]-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE
Authors:Brough, P.A., Aherne, W., Barril, X., Borgognoni, J., Boxal, K., Cansfield, J.E., Cheung, K.M., Collins, I., Davies, N.G.M., Drysdale, M.J., Dymock, B., Eccles, S.A., Finch, H., Fink, A., Hayes, A., Howes, R., Hubbard, R.E., James, K., Jordan, A.M., Lockie, A., Martins, V., Massey, A., Matthews, T.P., McDonald, E., Northfield, C.J., Pearl, L.H., Prodromou, C., Ray, S., Raynaud, F.I., Roughley, S.D., Sharp, S.Y., Surgenor, A., Walmsley, D.L., Webb, P., Wood, M., Workman, P., Wright, L.
Deposit date:2007-09-24
Release date:2007-12-11
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J. Med. Chem., 51, 2008
2VCJ
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4,5 DIARYL ISOXAZOLE HSP90 CHAPERONE INHIBITORS: POTENTIAL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER
Descriptor:HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide
Authors:Brough, P.A., Aherne, W., Barril, X., Borgognoni, J., Boxal, K., Cansfield, J.E., Cheung, K.M., Collins, I., Davies, N.G.M., Drysdale, M.J., Dymock, B., Eccles, S.A., Finch, H., Fink, A., Hayes, A., Howes, R., Hubbard, R.E., James, K., Jordan, A.M., Lockie, A., Martins, V., Massey, A., Matthews, T.P., McDonald, E., Northfield, C.J., Pearl, L.H., Prodromou, C., Ray, S., Raynaud, F.I., Roughley, S.D., Sharp, S.Y., Surgenor, A., Walmsley, D.L., Webb, P., Wood, M., Workman, P., Wright, L.
Deposit date:2007-09-24
Release date:2007-12-11
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J. Med. Chem., 51, 2008
2VW5
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STRUCTURE OF THE HSP90 INHIBITOR 7-O-CARBAMOYLPREMACBECIN BOUND TO THE N- TERMINUS OF YEAST HSP90
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (4E,8S,9R,10E,12S,13R,14S,16R)-13,20-dihydroxy-14-methoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(22),4,10,18,20-pentaen-9-yl carbamate, SULFATE ION
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2008-06-16
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors.
J.Med.Chem., 51, 2008
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