8OXU

Crystal Structure of the Hsp90-LA1011 Complex

Summary for 8OXU

Entry DOI	10.2210/pdb8oxu/pdb
Descriptor	ATP-dependent molecular chaperone HSP82, dimethyl 2,6-bis[2-(dimethylamino)ethyl]-1-methyl-4-[4-(trifluoromethyl)phenyl]-4~{H}-pyridine-3,5-dicarboxylate (3 entities in total)
Functional Keywords	inhibitor complex, chaperone
Biological source	Saccharomyces cerevisiae (baker's yeast)
Total number of polymer chains	4
Total formula weight	110250.86
Authors	Roe, S.M.,Prodromou, C. (deposition date: 2023-05-02, release date: 2023-07-12, Last modification date: 2023-08-09)
Primary citation	Roe, S.M.,Torok, Z.,McGown, A.,Horvath, I.,Spencer, J.,Pazmany, T.,Vigh, L.,Prodromou, C. The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer's Disease. Biomolecules, 13:-, 2023 Cited by PubMed: 37509087 DOI: 10.3390/biom13071051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.94 Å)

Structure validation