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4M4X
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STRUCTURE AND DIMERIZATION PROPERTIES OF THE ARYL HYDROCARBON RECEPTOR (AHR) PAS-A DOMAIN
分子名称:Aryl hydrocarbon receptor
著者Wu, D., Potluri, N., Kim, Y., Rastinejad, F.
登録日2013-08-07
公開日2013-09-18
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.551 Å)
主引用文献Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain.
Mol.Cell.Biol., 33, 2013
4ZP4
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX
分子名称:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
著者Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
登録日2015-05-07
公開日2015-08-12
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (2.355 Å)
主引用文献Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
4ZPH
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH PROFLAVINE
分子名称:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, PROFLAVIN
著者Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
登録日2015-05-07
公開日2015-08-12
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
4ZPK
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH HRE DNA
分子名称:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ...
著者Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
登録日2015-05-08
公開日2015-08-12
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
4ZPR
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-1A:ARNT COMPLEX WITH HRE DNA
分子名称:Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 1-alpha, DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ...
著者Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
登録日2015-05-08
公開日2015-08-12
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.902 Å)
主引用文献Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
4ZQD
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2A:ARNT COMPLEX WITH THE BENZOXADIAZOLE ANTAGONIST 0X3
分子名称:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
著者Wu, D., Potluri, N., Lu, J., Kim, Y., Rastinejad, F.
登録日2015-05-09
公開日2015-08-12
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.87 Å)
主引用文献Structural integration in hypoxia-inducible factors.
Nature, 524, 2015
5SY5
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CRYSTAL STRUCTURE OF THE HETERODIMERIC NPAS1-ARNT COMPLEX
分子名称:Aryl hydrocarbon receptor nuclear translocator, Neuronal PAS domain-containing protein 1
著者Wu, D., Su, X., Potluri, N., Kim, Y., Rastinejad, F.
登録日2016-08-10
公開日2016-11-09
実験手法X-RAY DIFFRACTION (3.201 Å)
主引用文献NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Elife, 5, 2016
5SY7
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CRYSTAL STRUCTURE OF THE HETERODIMERIC NPAS3-ARNT COMPLEX WITH HRE DNA
分子名称:Aryl hydrocarbon receptor nuclear translocator, Neuronal PAS domain-containing protein 3, DNA (5'-D(*GP*GP*CP*TP*GP*CP*GP*TP*AP*CP*GP*TP*GP*CP*GP*GP*GP*TP*CP*GP*T)-3'), ...
著者Wu, D., Su, X., Potluri, N., Kim, Y., Rastinejad, F.
登録日2016-08-10
公開日2016-11-09
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
Elife, 5, 2016
6E3S
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2 COMPLEX WITH ANTAGONIST PT2385
分子名称:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile
著者Wu, D., Su, X., Lu, J., Li, S., Hood, B., Vasile, S., Potluri, N., Diao, X., Kim, Y., Khorasanizadeh, S., Rastinejad, F.
登録日2018-07-15
公開日2019-02-13
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 2019
6E3T
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2 COMPLEX WITH ANTAGONIST T1001
分子名称:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, (6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole
著者Wu, D., Su, X., Lu, J., Li, S., Hood, B., Vasile, S., Potluri, N., Diao, X., Kim, Y., Khorasanizadeh, S., Rastinejad, F.
登録日2018-07-15
公開日2019-02-13
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 2019
6E3U
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CRYSTAL STRUCTURE OF THE HETERODIMERIC HIF-2 COMPLEX WITH AGONIST M1001
分子名称:Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, 3-{[2-(pyrrolidin-1-yl)phenyl]amino}-1H-1lambda~6~,2-benzothiazole-1,1-dione
著者Wu, D., Su, X., Lu, J., Li, S., Hood, B., Vasile, S., Potluri, N., Diao, X., Kim, Y., Khorasanizadeh, S., Rastinejad, F.
登録日2018-07-15
公開日2019-02-13
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 2019
4IQR
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MULTI-DOMAIN ORGANIZATION OF THE HNF4ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA
分子名称:Hepatocyte nuclear factor 4-alpha, DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), ...
著者Chandra, V., Huang, P., Kim, Y., Rastinejad, F.
登録日2013-01-13
公開日2013-03-20
最終更新日2013-10-23
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex.
Nature, 495, 2013
5TFP
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CRYSTAL STRUCTURE OF THE SETDB2 AMINO TERMINAL DOMAIN
分子名称:Histone-lysine N-methyltransferase SETDB2, GLYCEROL, L(+)-TARTARIC ACID
著者Khorasanizadeh, S., Kim, Y.
登録日2016-09-26
公開日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Identification of a helical dimerization domain in SETDB2 lysine methyltransferase
To Be Published
5UAN
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CRYSTAL STRUCTURE OF MULTI-DOMAIN RAR-BETA-RXR-ALPHA HETERODIMER ON DNA
分子名称:Retinoic acid receptor RXR-alpha, Retinoic acid receptor beta, Nuclear receptor coactivator 2, ...
著者Chandra, V., Wu, D., Kim, Y., Rastinejad, F.
登録日2016-12-19
公開日2017-10-18
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (3.508 Å)
主引用文献The quaternary architecture of RAR beta-RXR alpha heterodimer facilitates domain-domain signal transmission.
Nat Commun, 8, 2017