Author results

4JA7
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RAT PP5 CO-CRYSTALLIZED WITH P5SA-2
Descriptor:Serine/threonine-protein phosphatase 5, MAGNESIUM ION
Authors:Haslbeck, V., Helmuth, M., Alte, F., Popowicz, G., Schmidt, W., Weiwad, M., Fischer, G., Gemmecker, G., Sattler, M., Striggow, F., Groll, M., Richter, K.
Deposit date:2013-02-18
Release date:2014-02-19
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Biosci.Rep., 35, 2015
4JA9
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RAT PP5 APO
Descriptor:Serine/threonine-protein phosphatase 5, MAGNESIUM ION
Authors:Haslbeck, V., Helmuth, M., Alte, F., Popowicz, G., Schmidt, W., Weiwad, M., Fischer, G., Gemmecker, G., Sattler, M., Striggow, F., Groll, M., Richter, K.
Deposit date:2013-02-18
Release date:2014-02-19
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Biosci.Rep., 35, 2015
1OH1
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SOLUTION STRUCTURE OF STAPHOSTATIN A FORM STAPHYLOCOCCUS AUREUS CONFIRMS THE DISCOVERY OF A NOVEL CLASS OF CYSTEINE PROTEINASE INHIBITORS.
Descriptor:STAPHOSTATIN A
Authors:Dubin, G., Popowicz, G., Krajewski, M., Stec, J., Bochtler, M., Potempa, J., Dubin, A., Holak, T.A.
Deposit date:2003-05-21
Release date:2003-11-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Novel Class of Cysteine Protease Inhibitors: Solution Structure of Staphostatin a from Staphylococcus Aureus
Biochemistry, 42, 2003
4K1S
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GLY-SER-SPLB PROTEASE FROM STAPHYLOCOCCUS AUREUS AT 1.96 A RESOLUTION
Descriptor:Serine protease SplB
Authors:Zdzalik, M., Pustelny, K., Stec-Niemczyk, J., Cichon, P., Czarna, A., Popowicz, G., Drag, M., Wladyka, B., Potempa, J., Dubin, A., Dubin, G.
Deposit date:2013-04-05
Release date:2014-04-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Staphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of Activation.
J.Biol.Chem., 289, 2014
4K1T
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GLY-SER-SPLB PROTEASE FROM STAPHYLOCOCCUS AUREUS AT 1.60 A RESOLUTION
Descriptor:Serine protease SplB, ZINC ION, SULFATE ION, ...
Authors:Zdzalik, M., Pustelny, K., Stec-Niemczyk, J., Cichon, P., Czarna, A., Popowicz, G., Drag, M., Wladyka, B., Potempa, J., Dubin, A., Dubin, G.
Deposit date:2013-04-05
Release date:2014-04-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Staphylococcal SplB Serine Protease Utilizes a Novel Molecular Mechanism of Activation.
J.Biol.Chem., 289, 2014
5BPK
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VARYING BINDING MODES OF INHIBITORS AND STRUCTURAL DIFFERENCES IN THE BINDING POCKETS OF DIFFERENT GAMMA-GLUTAMYLTRANSPEPTIDASES
Descriptor:Gamma-glutamyltranspeptidase (Ggt), 1,2-ETHANEDIOL, (2S)-amino[(5S)-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
Authors:Bolz, C., Bach, N.C., Meyer, H., Mueller, G., Dawidowski, M., Popowicz, G., Sieber, S.A., Skerra, A., Gerhard, M.
Deposit date:2015-05-28
Release date:2016-05-18
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
To Be Published
5OML
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CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI PEX14 N-TERMINAL DOMAIN IN COMPLEX WITH SMALL MOLECULES TO INVESTIGATE THE WATER ENVELOPE
Descriptor:Peroxin 14, (3~{R})-3-[[1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-3-yl]carbonylamino]-3-phenyl-propanoic acid, SULFATE ION, ...
Authors:Ratkova, E.L., Dawidowski, M., Napolitano, V., Dubin, G., Fino, R., Popowicz, G., Sattler, M., Tetko, I.V.
Deposit date:2017-08-01
Release date:2019-03-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of Trypanosoma Brucei PEX14 N-terminal domain in complex with small molecules to investigate the water envelope
To Be Published
3UFA
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CRYSTAL STRUCTURE OF THE STAPHYLOCOCCAL SERINE PROTEASE SPLA IN COMPLEX WITH A SPECIFIC PHOSPHONATE INHIBITOR
Descriptor:Serine protease splA, N-(3-carboxypropanoyl)-L-valyl-N-[(1S)-2-phenyl-1-phosphonoethyl]-L-prolinamide, CHLORIDE ION
Authors:Zdzalik, M., Pietrusewicz, E., Pustelny, K., Stec-Niemczyk, J., Popowicz, G.M., Potempa, J., Oleksyszyn, J., Dubin, G.
Deposit date:2011-10-31
Release date:2013-01-23
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.
Protein Sci., 23, 2014
4MVN
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CRYSTAL STRUCTURE OF THE STAPHYLOCOCCAL SERINE PROTEASE SPLA IN COMPLEX WITH A SPECIFIC PHOSPHONATE INHIBITOR
Descriptor:Serine protease splA, [(1S)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl]phosphonic acid
Authors:Zdzalik, M., Burchacka, E., Niemczyk, J.S., Pustelny, K., Popowicz, G.M., Wladyka, B., Dubin, A., Potempa, J., Sienczyk, M., Dubin, G., Oleksyszyn, J.
Deposit date:2013-09-24
Release date:2014-01-22
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus.
Protein Sci., 23, 2014
4MDN
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STRUCTURE OF A NOVEL SUBMICROMOLAR MDM2 INHIBITOR
Descriptor:E3 ubiquitin-protein ligase Mdm2, 3-{(1S)-2-(tert-butylamino)-1-[{4-[(4-chlorobenzyl)oxy]benzyl}(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid, SULFATE ION
Authors:Bista, M., Popowicz, G., Holak, T.A.
Deposit date:2013-08-23
Release date:2013-11-13
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (1.905 Å)
Cite:Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction.
Structure, 21, 2013
4MDQ
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STRUCTURE OF A NOVEL SUBMICROMOLAR MDM2 INHIBITOR
Descriptor:E3 ubiquitin-protein ligase Mdm2, 3-[(1R)-2-(benzylamino)-1-{[(2S)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl]-6-chloro-N-hydroxy-1H-indole-2-carboxamide
Authors:Bista, M., Popowicz, G., Holak, T.A.
Deposit date:2013-08-23
Release date:2013-11-13
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (2.119 Å)
Cite:Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction.
Structure, 21, 2013