4MVN

Crystal structure of the staphylococcal serine protease SplA in complex with a specific phosphonate inhibitor

Summary for 4MVN

Entry DOI	10.2210/pdb4mvn/pdb
Related	2W7U 3UFA 3W7S
Descriptor	Serine protease splA, [(1S)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl]phosphonic acid (3 entities in total)
Functional Keywords	chymotrypsin-like fold, serine endopeptidase, extracellular staphylococcal proteases, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Staphylococcus aureus
Cellular location	Secreted: Q2FXC2
Total number of polymer chains	4
Total formula weight	88883.10
Authors	Zdzalik, M.,Burchacka, E.,Niemczyk, J.S.,Pustelny, K.,Popowicz, G.M.,Wladyka, B.,Dubin, A.,Potempa, J.,Sienczyk, M.,Dubin, G.,Oleksyszyn, J. (deposition date: 2013-09-24, release date: 2014-01-22, Last modification date: 2023-11-08)
Primary citation	Burchacka, E.,Zdzalik, M.,Niemczyk, J.S.,Pustelny, K.,Popowicz, G.,Wladyka, B.,Dubin, A.,Potempa, J.,Sienczyk, M.,Dubin, G.,Oleksyszyn, J. Development and binding characteristics of phosphonate inhibitors of SplA protease from Staphylococcus aureus. Protein Sci., 23:179-189, 2014 Cited by PubMed: 24375505 DOI: 10.1002/pro.2403 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation