6R73

Structure of IMP-13 metallo-beta-lactamase complexed with hydrolysed meropenem

Summary for 6R73

Entry DOI	10.2210/pdb6r73/pdb
Descriptor	Beta-lactamase, (2~{S},3~{R},4~{S})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-(dimethylcarbamoy l)pyrrolidin-3-yl]sulfanyl-3-methyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, ZINC ION, ... (4 entities in total)
Functional Keywords	metallo-beta-lactamase, zinc-binding protein, antibiotic resistance, hydrolase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	2
Total formula weight	51285.66
Authors	Softley, C.A.,Zak, K.,Kolonko, M.,Sattler, M.,Popowicz, G. (deposition date: 2019-03-28, release date: 2020-03-25, Last modification date: 2024-01-24)
Primary citation	Softley, C.A.,Zak, K.M.,Bostock, M.J.,Fino, R.,Zhou, R.X.,Kolonko, M.,Mejdi-Nitiu, R.,Meyer, H.,Sattler, M.,Popowicz, G.M. Structure and Molecular Recognition Mechanism of IMP-13 Metallo-beta-Lactamase. Antimicrob.Agents Chemother., 64:-, 2020 Cited by PubMed: 32205343 DOI: 10.1128/AAC.00123-20 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation