Author results

1QKM
  • Download 1qkm
  • View 1qkm
Molmil generated image of 1qkm
HUMAN OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH PARTIAL AGONIST GENISTEIN
分子名称:ESTROGEN RECEPTOR BETA, GENISTEIN
著者Pike, A.C.W., Brzozowski, A.M., Carlquist, M.
登録日1999-07-27
公開日2000-07-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of the Ligand-Binding Domain of Oestrogen Receptor Beta in the Presence of a Partial Agonist and a Full Antagonist
Embo J., 18, 1999
1QKN
  • Download 1qkn
  • View 1qkn
Molmil generated image of 1qkn
RAT OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH ANTAGONIST RALOXIFENE
分子名称:ESTROGEN RECEPTOR BETA, ACETATE ION, RALOXIFENE
著者Pike, A.C.W., Brzozowski, A.M., Carlquist, M.
登録日1999-07-27
公開日2000-07-28
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure of the Ligand-Binding Domain of Oestrogen Receptor Beta in the Presence of a Partial Agonist and a Full Antagonist
Embo J., 18, 1999
2WWY
  • Download 2wwy
  • View 2wwy
Molmil generated image of 2wwy
STRUCTURE OF HUMAN RECQ-LIKE HELICASE IN COMPLEX WITH A DNA SUBSTRATE
分子名称:ATP-DEPENDENT DNA HELICASE Q1, DNA OLIGO (27BP), 5'-D(*DA DG DC DG DT DC DG DA DG DA DT DC DCP)-3', ...
著者Pike, A.C.W., Zhang, Y., Schnecke, C., Chaikuad, A., Krojer, T., Cooper, C.D.O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Gileadi, O.
登録日2009-10-30
公開日2009-12-29
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Recq1 Helicase-Driven DNA Unwinding, Annealing, and Branch Migration: Insights from DNA Complex Structures
Proc.Natl.Acad.Sci.USA, 112, 2015
1HJ1
  • Download 1hj1
  • View 1hj1
Molmil generated image of 1hj1
RAT OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH PURE ANTIOESTROGEN ICI164,384
分子名称:OESTROGEN RECEPTOR BETA, N-BUTYL-11-[(7R,8R,9S,13S,14S,17S)-3,17-DIHYDROXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-7-YL]-N-METHYLUNDECANAMIDE, PARA-MERCURY-BENZENESULFONIC ACID, ...
著者Pike, A.C.W., Brzozowski, A.M., Carlquist, M.
登録日2001-01-08
公開日2002-01-04
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Insights Into the Mode of Action of a Pure Antiestrogen
Structure, 9, 2001
2CLS
  • Download 2cls
  • View 2cls
Molmil generated image of 2cls
THE CRYSTAL STRUCTURE OF THE HUMAN RND1 GTPASE IN THE ACTIVE GTP BOUND STATE
分子名称:RHO-RELATED GTP-BINDING PROTEIN RHO6, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Pike, A.C.W., Yang, X., Colebrook, S., Gileadi, O., Sobott, F., Bray, J., Wen Hwa, L., Marsden, B., Zhao, Y., Schoch, G., Elkins, J., Debreczeni, J.E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.
登録日2006-04-28
公開日2006-05-04
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献The Crystal Structure of the Human Rnd1 Gtpase in the Active GTP Bound State
To be Published
2IZZ
  • Download 2izz
  • View 2izz
Molmil generated image of 2izz
CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATE REDUCTASE
分子名称:PYRROLINE-5-CARBOXYLATE REDUCTASE 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL
著者Pike, A.C.W., Guo, K., Kavanagh, K., Pilka, E.S., Berridge, G., Colebrook, S., Bray, J., Salah, E., Savitsky, P., Papagrigoriou, E., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U.
登録日2006-07-31
公開日2006-08-01
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal Structure of Human Pyrroline-5-Carboxylate Reductase
To be Published
2J1L
  • Download 2j1l
  • View 2j1l
Molmil generated image of 2j1l
CRYSTAL STRUCTURE OF HUMAN RHO-RELATED GTP-BINDING PROTEIN RHOD
分子名称:RHO-RELATED GTP-BINDING PROTEIN RHOD, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Pike, A.C.W., Johansson, C., Gileadi, C., Niesen, F.H., Sobott, F., Schoch, G., Elkins, J., Smee, C., Gorrec, F., Watt, S., Bray, J., Turnbull, A.P., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Doyle, D.
登録日2006-08-14
公開日2006-09-18
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of Human Rho-Related GTP-Binding Protein Rhod
To be Published
2J51
  • Download 2j51
  • View 2j51
Molmil generated image of 2j51
CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE BOUND TO 5-AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO) -N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE- 1-CARBOTHIOAMIDE
分子名称:STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 1,2-ETHANEDIOL, THIOCYANATE ION, ...
著者Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Turnbull, A.P., Debreczeni, J.E., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
登録日2006-09-08
公開日2006-10-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2J7T
  • Download 2j7t
  • View 2j7t
Molmil generated image of 2j7t
CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 BOUND TO SU11274
分子名称:SERINE/THREONINE-PROTEIN KINASE 10, CALCIUM ION, ACETATE ION, ...
著者Pike, A.C.W., Rellos, P., Fedorov, O., Das, S., Debreczeni, J., Sobott, F., Watt, S., Savitsky, P., Eswaran, J., Turnbull, A.P., Papagrigoriou, E., Ugochukwa, E., Gorrec, F., Umeano, C.C., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
登録日2006-10-17
公開日2006-11-07
最終更新日2018-06-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2J7X
  • Download 2j7x
  • View 2j7x
Molmil generated image of 2j7x
STRUCTURE OF ESTRADIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5
分子名称:ESTROGEN RECEPTOR BETA, NUCLEAR RECEPTOR COACTIVATOR 5, ESTRADIOL, ...
著者Pike, A.C.W., Brzozowski, A.M., Hubbard, R.E., Walton, J., Bonn, T., Thorsell, A.-G., Engstrom, O., Ljunggren, J., Gustaffson, J.-A., Carlquist, M.
登録日2006-10-17
公開日2006-11-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of Agonist-Bound Estrogen Receptor Beta Lbd in Complex with Lxxll Motif from Ncoa5
To be Published
2J7Y
  • Download 2j7y
  • View 2j7y
Molmil generated image of 2j7y
STRUCTURE OF 17-EPIESTRIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5
分子名称:ESTROGEN RECEPTOR BETA, NUCLEAR RECEPTOR COACTIVATOR 5, (16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL, ...
著者Pike, A.C.W., Brzozowski, A.M., Hubbard, R.E., Walton, J., Bonn, T., Thorsell, A.-G., Engstrom, O., Ljunggren, J., Gustaffson, J.-A., Carlquist, M.
登録日2006-10-17
公開日2006-11-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of Agonist-Bound Estrogen Receptor Beta Lbd in Complex with Lxxll Motif from Ncoa5
To be Published
2JFL
  • Download 2jfl
  • View 2jfl
Molmil generated image of 2jfl
CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
分子名称:STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, 1,2-ETHANEDIOL, ...
著者Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Bunkoczi, G., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
登録日2007-02-02
公開日2007-02-27
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2JFM
  • Download 2jfm
  • View 2jfm
Molmil generated image of 2jfm
CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (UNLIGANDED FORM)
分子名称:STE20-LIKE SERINE-THREONINE KINASE, 1,2-ETHANEDIOL
著者Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Bunkoczi, G., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
登録日2007-02-02
公開日2007-02-27
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2JIF
  • Download 2jif
  • View 2jif
Molmil generated image of 2jif
STRUCTURE OF HUMAN SHORT-BRANCHED CHAIN ACYL-COA DEHYDROGENASE (ACADSB)
分子名称:SHORT/BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, FLAVIN-ADENINE DINUCLEOTIDE, COENZYME A PERSULFIDE, ...
著者Pike, A.C.W., Hozjan, V., Smee, C., Niesen, F.H., Kavanagh, K.L., Umeano, C., Turnbull, A.P., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Oppermann, U.
登録日2007-02-28
公開日2007-04-03
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Human Short-Branched Chain Acyl-Coa Dehydrogenase
To be Published
2UV2
  • Download 2uv2
  • View 2uv2
Molmil generated image of 2uv2
CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE BOUND TO 4-(4-(5- CYCLOPROPYL-1H-PYRAZOL-3-YLAMINO)-QUINAZOLIN-2-YLAMINO)-PHENYL)- ACETONITRILE
分子名称:STE20-LIKE SERINE-THREONINE KINASE, 1,2-ETHANEDIOL, THIOCYANATE ION, ...
著者Pike, A.C.W., Rellos, P., Fedorov, O., Keates, T., Salah, E., Savitsky, P., Papagrigoriou, E., Bunkoczi, G., Debreczeni, J.E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
登録日2007-03-08
公開日2007-03-20
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.
Embo J., 27, 2008
2UXW
  • Download 2uxw
  • View 2uxw
Molmil generated image of 2uxw
CRYSTAL STRUCTURE OF HUMAN VERY LONG CHAIN ACYL-COA DEHYDROGENASE (ACADVL)
分子名称:VERY-LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Pike, A.C.W., Hozjan, V., Smee, C., Berridge, G., Burgess, N., Salah, E., Bunkoczi, G., Uppenberg, J., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U.
登録日2007-03-30
公開日2007-05-01
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystal Structure of Human Very Long Chain Acyl- Coa Dehydrogenase (Acadvl)
To be Published
2UZP
  • Download 2uzp
  • View 2uzp
Molmil generated image of 2uzp
CRYSTAL STRUCTURE OF THE C2 DOMAIN OF HUMAN PROTEIN KINASE C GAMMA.
分子名称:PROTEIN KINASE C GAMMA TYPE, PYRIDOXAL-5'-PHOSPHATE, COBALT (II) ION, ...
著者Pike, A.C.W., Amos, A., Johansson, C., Sobott, F., Savitsky, P., Berridge, G., Fedorov, O., Umeano, C., Gorrec, F., Bunkoczi, G., Debreczeni, J., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S.
登録日2007-04-30
公開日2007-05-29
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of C2 Domain of Protein Kinase C Gamma
To be Published
2V1X
  • Download 2v1x
  • View 2v1x
Molmil generated image of 2v1x
CRYSTAL STRUCTURE OF HUMAN RECQ-LIKE DNA HELICASE
分子名称:ATP-DEPENDENT DNA HELICASE Q1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Pike, A.C.W., Shrestha, B., Burgess-Brown, N., King, O., Ugochukwu, E., Watt, S., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Gileadi, O.
登録日2007-05-30
公開日2007-07-03
最終更新日2015-01-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the Human Recq1 Helicase Reveals a Putative Strand-Separation Pin.
Proc.Natl.Acad.Sci.USA, 106, 2009
2VIG
  • Download 2vig
  • View 2vig
Molmil generated image of 2vig
CRYSTAL STRUCTURE OF HUMAN SHORT-CHAIN ACYL COA DEHYDROGENASE
分子名称:SHORT-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE,, FLAVIN-ADENINE DINUCLEOTIDE, 1,2-ETHANEDIOL, ...
著者Pike, A.C.W., Pantic, N., Parizotto, E., Gileadi, O., Ugochukwu, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Oppermann, U.
登録日2007-11-30
公開日2007-12-25
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure of Human Short-Chain Acyl Coa Dehydrogenase
To be Published
2VN8
  • Download 2vn8
  • View 2vn8
Molmil generated image of 2vn8
CRYSTAL STRUCTURE OF HUMAN RETICULON 4 INTERACTING PROTEIN 1 IN COMPLEX WITH NADPH
分子名称:RETICULON-4-INTERACTING PROTEIN 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SODIUM ION, ...
著者Pike, A.C.W., Guo, K., Elkins, J., Ugochukwu, E., Roos, A.K., Filippakopoulos, P., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Oppermann, U.
登録日2008-01-31
公開日2008-03-18
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of Human Reticulon 4 Interacting Protein 1 in Complex with Nadph
To be Published
2VSV
  • Download 2vsv
  • View 2vsv
Molmil generated image of 2vsv
CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOPHILIN-2
分子名称:RHOPHILIN-2
著者Pike, A.C.W., Kochan, G., Sun, Z., Shafqat, N., Pilka, E.S., Roos, A., Elkins, J., Burgess-Brown, N., Murray, J.W., von Delft, F., Wikstrom, M., Edwards, A., Arrowsmith, C.H., Bountra, C., Oppermann, U.
登録日2008-04-29
公開日2008-07-15
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Crystal Structure of the Pdz Domain of Human Rhophilin-2
To be Published
2X57
  • Download 2x57
  • View 2x57
Molmil generated image of 2x57
CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
分子名称:VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2
著者Pike, A.C.W., Barr, A.J., Quigley, A., Burgess Brown, N., de Riso, A., Bullock, A., Berridge, G., Muniz, J.R.C., Chaikaud, A., Vollmar, M., Krojer, T., Ugochukwu, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
登録日2010-02-05
公開日2010-03-09
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of the Extracellular Domain of Human Vasoactive Intestinal Polypeptide Receptor 2
To be Published
2X7G
  • Download 2x7g
  • View 2x7g
Molmil generated image of 2x7g
STRUCTURE OF HUMAN SERINE-ARGININE-RICH PROTEIN-SPECIFIC KINASE 2 (SRPK2) BOUND TO PURVALANOL B
分子名称:UNCHARACTERIZED PROTEIN SRPK2, PURVALANOL B, SULFATE ION, ...
著者Pike, A.C.W., Savitsky, P., Fedorov, O., Krojer, T., Ugochukwu, E., von Delft, F., Gileadi, O., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S.
登録日2010-02-26
公開日2010-04-14
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of Human Serine-Arginine-Rich Protein- Specific Kinase 2 (Srpk2) Bound to Purvalanol B
To be Published
2XDG
  • Download 2xdg
  • View 2xdg
Molmil generated image of 2xdg
CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR.
分子名称:GROWTH HORMONE-RELEASING HORMONE RECEPTOR, MAGNESIUM ION, 1,2-ETHANEDIOL
著者Pike, A.C.W., Quigley, A., Barr, A.J., Burgess Brown, N., Shrestha, L., Yang, J., Chaikuad, A., Vollmar, M., Muniz, J.R.C., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Carpenter, E.P.
登録日2010-04-30
公開日2010-06-16
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal Structure of the Extracellular Domain of Human Growth Hormone Releasing Hormone Receptor.
To be Published
4BW5
  • Download 4bw5
  • View 4bw5
Molmil generated image of 4bw5
CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1)
分子名称:POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, CADMIUM ION, ...
著者Pike, A.C.W., Dong, Y.Y., Dong, L., Quigley, A., Shrestha, L., Mukhopadhyay, S., Strain-Damerell, C., Goubin, S., Grieben, M., Shintre, C.A., Mackenzie, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N., Carpenter, E.P.
登録日2013-06-30
公開日2013-07-31
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac
Science, 347, 2015