2J51
Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide
Summary for 2J51
Entry DOI | 10.2210/pdb2j51/pdb |
Descriptor | STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 1,2-ETHANEDIOL, THIOCYANATE ION, ... (5 entities in total) |
Functional Keywords | transferase, serine/threonine-protein kinase, atp-binding, phosphorylation, muscle development, kinase, apoptosis, germinal centre kinase, serine/threonine kinase 2, nucleotide-binding |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm (By similarity): Q9H2G2 |
Total number of polymer chains | 1 |
Total formula weight | 37893.86 |
Authors | Pike, A.C.W.,Rellos, P.,Fedorov, O.,Keates, T.,Salah, E.,Savitsky, P.,Papagrigoriou, E.,Turnbull, A.P.,Debreczeni, J.E.,von Delft, F.,Arrowsmith, C.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Knapp, S. (deposition date: 2006-09-08, release date: 2006-10-03, Last modification date: 2023-12-13) |
Primary citation | Pike, A.C.W.,Rellos, P.,Niesen, F.H.,Turnbull, A.,Oliver, A.W.,Parker, S.A.,Turk, B.E.,Pearl, L.H.,Knapp, S. Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites. Embo J., 27:704-, 2008 Cited by PubMed: 18239682DOI: 10.1038/EMBOJ.2008.8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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