2J7T

Crystal structure of human serine threonine kinase-10 bound to SU11274

Summary for 2J7T

• Entry DOI: 10.2210/pdb2j7t/pdb
• Descriptor: SERINE/THREONINE-PROTEIN KINASE 10, CALCIUM ION, ACETATE ION, ... (5 entities in total)
• Functional Keywords: kinase, transferase, atp-binding, cell cycle progression, phosphorylation, disease mutation, nucleotide- binding, lymphocyte oriented kinase (lok), serine/threonine- protein kinase, serine/threonine kinase (stk10a)
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 35206.28

Authors

Pike, A.C.W.,Rellos, P.,Fedorov, O.,Das, S.,Debreczeni, J.,Sobott, F.,Watt, S.,Savitsky, P.,Eswaran, J.,Turnbull, A.P.,Papagrigoriou, E.,Ugochukwa, E.,Gorrec, F.,Umeano, C.C.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Knapp, S. (deposition date: 2006-10-17, release date: 2006-11-07, Last modification date: 2023-12-13)

• Primary citation: Pike, A.C.W.,Rellos, P.,Niesen, F.H.,Turnbull, A.,Oliver, A.W.,Parker, S.A.,Turk, B.E.,Pearl, L.H.,Knapp, S.; Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.; Embo J., 27:704-, 2008; PubMed: 18239682; DOI: 10.1038/EMBOJ.2008.8

Experimental method

X-RAY DIFFRACTION (2 Å)