2UV2

Crystal Structure Of Human Ste20-Like Kinase Bound To 4-(4-(5- Cyclopropyl-1H-pyrazol-3-ylamino)-quinazolin-2-ylamino)-phenyl)- acetonitrile

Replaces:  2JA0

Summary for 2UV2

• Entry DOI: 10.2210/pdb2uv2/pdb
• Related: 2J51 2JA0 2JFL 2JFM
• Descriptor: STE20-LIKE SERINE-THREONINE KINASE, 1,2-ETHANEDIOL, THIOCYANATE ION, ... (5 entities in total)
• Functional Keywords: transferase, serine/threonine-protein kinase, atp-binding, phosphorylation, muscle development, kinase, apoptosis, germinal centre kinase, serine- threonine kinase 2, nucleotide-binding, serine-threonine-protein kinase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm : Q9H2G2
• Total number of polymer chains: 1
• Total formula weight: 37970.01

Authors

Pike, A.C.W.,Rellos, P.,Fedorov, O.,Keates, T.,Salah, E.,Savitsky, P.,Papagrigoriou, E.,Bunkoczi, G.,Debreczeni, J.E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Knapp, S. (deposition date: 2007-03-08, release date: 2007-03-20, Last modification date: 2023-12-13)

• Primary citation: Pike, A.C.W.,Rellos, P.,Niesen, F.H.,Turnbull, A.,Oliver, A.W.,Parker, S.A.,Turk, B.E.,Pearl, L.H.,Knapp, S.; Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.; Embo J., 27:704-, 2008; PubMed: 18239682; DOI: 10.1038/EMBOJ.2008.8

Experimental method

X-RAY DIFFRACTION (2.3 Å)