2UV2
Crystal Structure Of Human Ste20-Like Kinase Bound To 4-(4-(5- Cyclopropyl-1H-pyrazol-3-ylamino)-quinazolin-2-ylamino)-phenyl)- acetonitrile
Replaces: 2JA0Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | STE20-LIKE SERINE-THREONINE KINASE | polymer | 325 | 37162.1 | 1 | UniProt (Q9H2G2) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | STE20-LIKE KINASE, STE20-RELATED SERINE/THREONINE-PROTEIN KINASE, STE20-RELATED KINASE, HSLK, SERINE/THREONINE-PROTEIN KINASE 2, CTCL TUMOR ANTIGEN SE20-9 |
| 2 | B, C, D, E, F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 3 | G, H (A) | THIOCYANATE ION | non-polymer | 58.1 | 2 | Chemie (SCN) | |||
| 4 | I (A) | [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE | non-polymer | 381.4 | 1 | Chemie (GVD) | |||
| 5 | J (A) | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A: -4 - 18 (PDB: 2UV2)
A: 19 - 320 (UniProt: Q9H2G2)
A: 19 - 320 (UniProt: Q9H2G2)
| PDB | External Database | Details |
|---|---|---|
| Thr 25 | Lys 25 | engineered mutation |
| Tpo 183 | Thr 183 | microheterogeneity |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37162.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 807.9 | |
| All* | Total formula weight | 37970.0 |
