2JFL
CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Summary for 2JFL
Entry DOI | 10.2210/pdb2jfl/pdb |
Related | 2J51 2JA0 2JFM |
Descriptor | STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | transferase, serine/threonine-protein kinase, atp-binding, phosphorylation, muscle development, kinase, apoptosis, germinal centre kinase, serine- threonine kinase 2, nucleotide-binding, serine-threonine-protein kinase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm : Q9H2G2 |
Total number of polymer chains | 1 |
Total formula weight | 38151.34 |
Authors | Pike, A.C.W.,Rellos, P.,Fedorov, O.,Keates, T.,Salah, E.,Savitsky, P.,Papagrigoriou, E.,Bunkoczi, G.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Knapp, S. (deposition date: 2007-02-02, release date: 2007-02-27, Last modification date: 2023-12-13) |
Primary citation | Pike, A.C.W.,Rellos, P.,Niesen, F.H.,Turnbull, A.,Oliver, A.W.,Parker, S.A.,Turk, B.E.,Pearl, L.H.,Knapp, S. Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites. Embo J., 27:704-, 2008 Cited by PubMed: 18239682DOI: 10.1038/EMBOJ.2008.8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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