2CLS

The crystal structure of the human RND1 GTPase in the active GTP bound state

Summary for 2CLS

DescriptorRHO-RELATED GTP-BINDING PROTEIN RHO6, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordsnucleotide-binding, gtp-binding protein rho6, membrane, prenylation, lipoprotein, gtp-binding, cytoskeleton, small gtpase, nucleotide binding protein
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCell membrane ; Lipid-anchor ; Cytoplasmic side  Q92730
Total number of polymer chains2
Total molecular weight45309.74
Authors
Primary citation
Pike, A.C.W.,Yang, X.,Colebrook, S.,Gileadi, O.,Sobott, F.,Bray, J.,Wen Hwa, L.,Marsden, B.,Zhao, Y.,Schoch, G.,Elkins, J.,Debreczeni, J.E.,Turnbull, A.P.,von Delft, F.,Arrowsmith, C.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Doyle, D.
The Crystal Structure of the Human Rnd1 Gtpase in the Active GTP Bound State
To be Published,
Experimental method
X-RAY DIFFRACTION (2.31 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23871.7%7.2%9.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2cls
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Molmil generated image of 2cls
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Molmil generated image of 2cls
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More Biological unit images

Molmil generated image of 2cls
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Molmil generated image of 2cls
rotated about x axis by 90°
Molmil generated image of 2cls
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2cls.pdb1.gz [31.54 KB])
Coordinate files for Biological unit (2cls.pdb2.gz [31.18 KB])