Author results

1RF4
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STRUCTURAL STUDIES OF STREPTOCOCCUS PNEUMONIAE EPSP SYNTHASE, TETRAHEDRAL INTERMEDIATE BOUND STATE
Descriptor:5-enolpyruvylshikimate-3-phosphate synthase, (3R,4S,5R)-5-{[(1R)-1-CARBOXY-2-FLUORO-1-(PHOSPHONOOXY)ETHYL]OXY}-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Authors:Park, H., Hilsenbeck, J.L., Kim, H.J., Shuttleworth, W.A., Park, Y.H., Evans, J.N., Kang, C.
Deposit date:2003-11-07
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
1RF5
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STRUCTURAL STUDIES OF STREPTOCOCCUS PNEUMONIAE EPSP SYNTHASE IN UNLIGANDED STATE
Descriptor:5-enolpyruvylshikimate-3-phosphate synthase
Authors:Park, H., Hilsenbeck, J.L., Kim, H.J., Shuttleworth, W.A., Park, Y.H., Evans, J.N., Kang, C.
Deposit date:2003-11-07
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
1RF6
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STRUCTURAL STUDIES OF STREPTOCOCCUS PNEUMONIAE EPSP SYNTHASE IN S3P-GLP BOUND STATE
Descriptor:5-enolpyruvylshikimate-3-phosphate synthase, GLYPHOSATE, SHIKIMATE-3-PHOSPHATE
Authors:Park, H., Hilsenbeck, J.L., Kim, H.J., Shuttleworth, W.A., Park, Y.H., Evans, J.N., Kang, C.
Deposit date:2003-11-07
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
1N4E
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CRYSTAL STRUCTURE OF A DNA DECAMER CONTAINING A THYMINE-DIMER
Descriptor:5'-D(*GP*CP*TP*TP*AP*AP*TP*TP*CP*G)-3', 5'-D(*CP*GP*AP*AP*TP*TP*AP*AP*GP*C)-3'
Authors:Park, H., Zhang, K., Ren, Y., Nadji, S., Sinha, N., Taylor, J.-S., Kang, C.
Deposit date:2002-10-30
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a DNA decamer containing a cis-syn thymine dimer.
Proc.Natl.Acad.Sci.USA, 99, 2002
1SM5
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CRYSTAL STRUCTURE OF A DNA DECAMER CONTAINING A THYMINE-DIMER
Descriptor:5'-D(*GP*CP*(BRU)P*TP*AP*AP*TP*(BRU)P*CP*G)-3', 5'-D(*CP*GP*AP*AP*TP*TP*AP*AP*GP*C)-3'
Authors:Park, H., Zhang, K., Ren, Y., Nadji, S., Sinha, N., Taylor, J.-S., Kang, C.
Deposit date:2004-03-08
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of a DNA Decamer Containing a Thymine-dimer
Proc.Natl.Acad.Sci.USA, 99, 2002
1T4I
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CRYSTAL STRUCTURE OF A DNA DECAMER CONTAINING A THYMINE-DIMER
Descriptor:5'-D(*GP*CP*TP*TP*AP*AP*TP*TP*CP*G)-3', 5'-D(*CP*GP*AP*AP*TP*TP*AP*AP*GP*C)-3'
Authors:Park, H., Zhang, K., Ren, Y., Nadji, S., Sinha, N., Taylor, J.S., Kang, C.
Deposit date:2004-04-29
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of a DNA Decamer Containing a cis-syn Thymine-dimer
Proc.Natl.Acad.Sci.USA, 99, 2002
1YPO
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HUMAN OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR LOX-1 P3 1 21 SPACE GROUP
Descriptor:oxidised low density lipoprotein (lectin-like) receptor 1
Authors:Park, H., Adsit, F.G., Boyington, J.C.
Deposit date:2005-01-31
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
J.Biol.Chem., 280, 2005
1YPQ
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HUMAN OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR LOX-1 DIOXANE COMPLEX
Descriptor:oxidised low density lipoprotein (lectin-like) receptor 1, 1,4-DIETHYLENE DIOXIDE
Authors:Park, H., Adsit, F.G., Boyington, J.C.
Deposit date:2005-01-31
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
J.Biol.Chem., 280, 2005
1YPU
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HUMAN OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR LOX-1 C2 SPACE GROUP
Descriptor:oxidised low density lipoprotein (lectin-like) receptor 1
Authors:Park, H., Adsit, F.G., Boyington, J.C.
Deposit date:2005-01-31
Release date:2005-02-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
J.Biol.Chem., 280, 2005
3O3U
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CRYSTAL STRUCTURE OF HUMAN RECEPTOR FOR ADVANCED GLYCATION ENDPRODUCTS (RAGE)
Descriptor:Maltose-binding periplasmic protein, Advanced glycosylation end product-specific receptor, MALTOTRIOSE, ...
Authors:Park, H., Boyington, J.C.
Deposit date:2010-07-26
Release date:2010-10-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding.
J.Biol.Chem., 285, 2010
3RF3
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SHIGELLA IPAA-VBS3 IN COMPLEX WITH HUMAN VINCULIN
Descriptor:Vinculin, Invasin ipaA, CACODYLATE ION
Authors:Park, H., Sharff, A., Izard, T.
Deposit date:2011-04-05
Release date:2011-04-27
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Novel vinculin binding site of the IpaA invasin of Shigella.
J.Biol.Chem., 286, 2011
3TJ5
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HUMAN VINCULIN HEAD DOMAIN (VH1, RESIDUES 1-258) IN COMPLEX WITH THE VINCULIN BINDING SITE OF THE SURFACE CELL ANTIGEN 4 (SCA4-VBS-N; RESIDUES 412-434) FROM RICKETTSIA RICKETTSII
Descriptor:Vinculin, Antigenic heat-stable 120 kDa protein, GLYCEROL
Authors:Park, H., Lee, J.H., Gouin, E., Cossart, P., Izard, T.
Deposit date:2011-08-23
Release date:2011-09-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.
J.Biol.Chem., 286, 2011
3TJ6
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HUMAN VINCULIN HEAD DOMAIN (VH1, RESIDUES 1-258) IN COMPLEX WITH THE VINCULIN BINDING SITE OF THE SURFACE CELL ANTIGEN 4 (SCA4-VBS-C; RESIDUES 812-835) FROM RICKETTSIA RICKETTSII
Descriptor:Vinculin, Antigenic heat-stable 120 kDa protein
Authors:Park, H., Lee, J.H., Gouin, E., Cossart, P., Izard, T.
Deposit date:2011-08-23
Release date:2011-09-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.
J.Biol.Chem., 286, 2011
4W4V
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JNK2/3 IN COMPLEX WITH 3-(4-{[(2-CHLOROPHENYL)CARBAMOYL]AMINO}-1H-PYRAZOL-1-YL)-N-(2-METHYLPYRIDIN-4-YL)BENZAMIDE
Descriptor:c-Jun N-terminal kinase 3, 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
Authors:Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P.
Deposit date:2014-08-15
Release date:2015-02-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
4W4W
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JNK2/3 IN COMPLEX WITH N-(2-METHYLPYRIDIN-4-YL)-3-{4-[(PHENYLCARBAMOYL)AMINO]-1H-PYRAZOL-1-YL}BENZAMIDE
Descriptor:c-Jun N-terminal kinase 3, N-(2-methylpyridin-4-yl)-3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}benzamide
Authors:Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P.
Deposit date:2014-08-15
Release date:2015-02-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
4W4X
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JNK2/3 IN COMPLEX WITH 3-(4-{[(4-FLUOROPHENYL)CARBAMOYL]AMINO}-1H-PYRAZOL-1-YL)-N-(2-METHYLPYRIDIN-4-YL)BENZAMIDE
Descriptor:c-jun NH2-terminal kinase 3, 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
Authors:Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P.
Deposit date:2014-08-15
Release date:2015-02-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
4W4Y
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JNK2/3 IN COMPLEX WITH 3-(4-{[(4-METHYLPHENYL)CARBAMOYL]AMINO}-1H-PYRAZOL-1-YL)-N-(2-METHYLPYRIDIN-4-YL)BENZAMIDE
Descriptor:c-jun NH2-terminal kinase 3, 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
Authors:Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P.
Deposit date:2014-08-15
Release date:2015-02-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
5BTM
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CRYSTAL STRUCTURE OF AUUCU REPEATING RNA THAT CAUSES SPINOCEREBELLAR ATAXIA TYPE 10 (SCA10)
Descriptor:RNA (55-mer), MAGNESIUM ION, SODIUM ION
Authors:Park, H.
Deposit date:2015-06-03
Release date:2015-07-15
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.778 Å)
Cite:Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10).
Biochemistry, 54, 2015
6BA5
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POTENT AND SELECTIVE ANTITUMOR ACTIVITY OF A T-CELL ENGAGING BISPECIFIC ANTIBODY TARGETING A MEMBRANE-PROXIMAL EPITOPE OF ROR1
Descriptor:Variable domain of Light Chain, antibody R11, Variable domain Heavy chain, ...
Authors:Park, H., Rader, C.
Deposit date:2017-10-12
Release date:2018-06-13
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4Y46
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PYRIDOPYRIMIDINONE DERIVATIVES AS POTENT AND SELECTIVE C-JUN N-TERMINAL KINASE (JNK) INHIBITORS
Descriptor:Mitogen-activated protein kinase 10, 1-{trans-4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl}-3-propan-2-ylurea
Authors:Park, H.
Deposit date:2015-02-10
Release date:2015-05-06
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
4Y5H
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PYRIDOPYRIMIDINONE DERIVATIVES AS POTENT AND SELECTIVE C-JUN N-TERMINAL KINASE (JNK) INHIBITORS
Descriptor:Mitogen-activated protein kinase 10, 1-(trans-4-{[7-oxo-8-(propan-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea
Authors:Park, H.
Deposit date:2015-02-11
Release date:2015-05-06
Method:X-RAY DIFFRACTION (2.055 Å)
Cite:Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
6BAN
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POTENT AND SELECTIVE ANTITUMOR ACTIVITY OF A T-CELL ENGAGING BISPECIFIC ANTIBODY TARGETING A MEMBRANE-PROXIMAL EPITOPE OF ROR1
Descriptor:Variable domain of R11 Light Chain, Variable domain R11 Heavy chain, Inactive tyrosine-protein kinase transmembrane receptor ROR1
Authors:Park, H., Rader, C.
Deposit date:2017-10-14
Release date:2018-06-13
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3V6R
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DISCOVERY OF POTENT AND SELECTIVE COVALENT INHIBITORS OF JNK
Descriptor:Mitogen-activated protein kinase 10, 4-{[4-(dimethylamino)butanoyl]amino}-N-(3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide
Authors:Park, H., LoGrasso, P.V., Laughlin, J.D.
Deposit date:2011-12-20
Release date:2012-02-01
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of potent and selective covalent inhibitors of JNK.
Chem.Biol., 19, 2012
3V6S
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DISCOVERY OF POTENT AND SELECTIVE COVALENT INHIBITORS OF JNK
Descriptor:Mitogen-activated protein kinase 10, 3-{[4-(dimethylamino)butanoyl]amino}-N-(4-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide
Authors:Park, H., Laughlin, J.D., LoGrasso, P.V.
Deposit date:2011-12-20
Release date:2012-02-01
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Discovery of potent and selective covalent inhibitors of JNK.
Chem.Biol., 19, 2012
4J50
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CRYSTAL STRUCTURE OF AN EXPANDED RNA CAG REPEAT
Descriptor:RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*AP*GP*CP*AP*GP*CP*AP*GP*GP*UP*CP*C)-3'), PHOSPHATE ION
Authors:Park, H., Disney, M.D.
Deposit date:2013-02-07
Release date:2013-02-20
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations.
J.Am.Chem.Soc., 135, 2013
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