7S1N
N-Aromatic-Substituted Indazole Derivatives as Brain Penetrant and Orally Bioavailable JNK3 Inhibitors
Summary for 7S1N
Entry DOI | 10.2210/pdb7s1n/pdb |
Descriptor | Mitogen-activated protein kinase 10, 4-[5-(2-chloro-6-fluoroanilino)-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl]-N-(oxetan-3-yl)thiophene-2-carboxamide (3 entities in total) |
Functional Keywords | mapk10, jnk3, kinase inhibitor, alzheimers diseases, indazole, azaindazole, neurodegeneration, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 53107.24 |
Authors | Park, H. (deposition date: 2021-09-02, release date: 2021-11-03, Last modification date: 2023-10-18) |
Primary citation | Feng, Y.,Park, H.,Ryu, J.C.,Yoon, S.O. N -Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors. Acs Med.Chem.Lett., 12:1546-1552, 2021 Cited by PubMed: 34676036DOI: 10.1021/acsmedchemlett.1c00334 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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