7S1N

N-Aromatic-Substituted Indazole Derivatives as Brain Penetrant and Orally Bioavailable JNK3 Inhibitors

Summary for 7S1N

Entry DOI	10.2210/pdb7s1n/pdb
Descriptor	Mitogen-activated protein kinase 10, 4-[5-(2-chloro-6-fluoroanilino)-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl]-N-(oxetan-3-yl)thiophene-2-carboxamide (3 entities in total)
Functional Keywords	mapk10, jnk3, kinase inhibitor, alzheimers diseases, indazole, azaindazole, neurodegeneration, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	53107.24
Authors	Park, H. (deposition date: 2021-09-02, release date: 2021-11-03, Last modification date: 2023-10-18)
Primary citation	Feng, Y.,Park, H.,Ryu, J.C.,Yoon, S.O. N -Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors. Acs Med.Chem.Lett., 12:1546-1552, 2021 Cited by PubMed: 34676036 DOI: 10.1021/acsmedchemlett.1c00334 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation