4Y5H
Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors
Summary for 4Y5H
Entry DOI | 10.2210/pdb4y5h/pdb |
Related | 4Y46 |
Descriptor | Mitogen-activated protein kinase 10, 1-(trans-4-{[7-oxo-8-(propan-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea (3 entities in total) |
Functional Keywords | jnk, map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P53779 |
Total number of polymer chains | 1 |
Total formula weight | 42648.44 |
Authors | Park, H. (deposition date: 2015-02-11, release date: 2015-05-06, Last modification date: 2024-02-28) |
Primary citation | Zheng, K.,Park, C.M.,Iqbal, S.,Hernandez, P.,Park, H.,LoGrasso, P.V.,Feng, Y. Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors. Acs Med.Chem.Lett., 6:413-418, 2015 Cited by PubMed: 25893042DOI: 10.1021/ml500474d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.055 Å) |
Structure validation
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