4Y5H
Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 10 | polymer | 366 | 42261.9 | 1 | UniProt (P53779) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAPK 10,MAP kinase p49 3F12,Stress-activated protein kinase 1b,SAPK1b,Stress-activated protein kinase JNK3,c-Jun N-terminal kinase 3 |
| 2 | A | 1-(trans-4-{[7-oxo-8-(propan-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea | non-polymer | 386.5 | 1 | Chemie (519) | |||
| 3 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 39 - 402 (UniProt: P53779)
| PDB | External Database | Details |
|---|---|---|
| Met 37 | - | expression tag |
| Ala 38 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42261.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 386.5 | |
| All* | Total formula weight | 42648.4 |
