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1GS0
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BU of 1gs0 by Molmil
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2
Descriptor: POLY (ADP-RIBOSE) POLYMERASE-2
Authors:Oliver, A.W, Roe, S.M, Pearl, L.H.
Deposit date:2001-12-19
Release date:2002-12-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Catalytic Fragment of Murine Poly(Adp-Ribose) Polymerase-2
Nucleic Acids Res., 32, 2004
1W4S
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BU of 1w4s by Molmil
Crystal structure of the proximal BAH domain of polybromo
Descriptor: CHLORIDE ION, POLYBROMO 1 PROTEIN
Authors:Oliver, A.W, Roe, S.M, Pearl, L.H.
Deposit date:2004-07-28
Release date:2005-04-27
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of the Proximal Bah Domain of the Polybromo Protein
Biochem.J., 389, 2005
2CN8
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BU of 2cn8 by Molmil
Crystal structure of human Chk2 in complex with debromohymenialdisine
Descriptor: DEBROMOHYMENIALDISINE, MAGNESIUM ION, NITRATE ION, ...
Authors:Oliver, A.W, Pearl, L.H.
Deposit date:2006-05-18
Release date:2006-06-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Trans-Activation of the DNA-Damage Signalling Protein Kinase Chk2 by T-Loop Exchange
Embo J., 25, 2006
2CN5
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BU of 2cn5 by Molmil
Crystal structure of human Chk2 in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Oliver, A.W, Pearl, L.H.
Deposit date:2006-05-18
Release date:2006-06-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Trans-Activation of the DNA-Damage Signalling Protein Kinase Chk2 by T-Loop Exchange
Embo J., 25, 2006
3EU7
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BU of 3eu7 by Molmil
Crystal Structure of a PALB2 / BRCA2 complex
Descriptor: 19meric peptide from Breast cancer type 2 susceptibility protein, GLYCEROL, Partner and localizer of BRCA2
Authors:Oliver, A.W, Pearl, L.H.
Deposit date:2008-10-09
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for recruitment of BRCA2 by PALB2
Embo Rep., 10, 2009
2W18
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BU of 2w18 by Molmil
Crystal structure of the C-terminal WD40 domain of human PALB2
Descriptor: GLYCEROL, PARTNER AND LOCALIZER OF BRCA2
Authors:Oliver, A.W, Pearl, L.H.
Deposit date:2008-10-15
Release date:2009-07-28
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Recruitment of Brca2 by Palb2
Embo Rep., 10, 2009
4UUH
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BU of 4uuh by Molmil
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, 5-methyl-3-[4-(piperazin-1-ylmethyl)phenyl]isoquinolin-1(2H)-one, GLYCEROL, ...
Authors:Oliver, A.W, Rajasekaran, M.B, Pearl, L.H.
Deposit date:2014-07-28
Release date:2015-07-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1- Ones as Potent and Selective Tankyrase Inhibitors
Medchemcommm, 6, 2015
4UW1
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BU of 4uw1 by Molmil
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, 3-{4-[(dimethylamino)methyl]phenyl}-5-methoxyisoquinolin-1(2H)-one, GLYCEROL, ...
Authors:Oliver, A.W, Rajasekaran, M.B, Pearl, L.H.
Deposit date:2014-08-08
Release date:2015-07-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.37 Å)
Cite:Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors
Medchemcommm, 6, 2015
4U6A
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BU of 4u6a by Molmil
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, 3-(4-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)-5-methylisoquinolin-1(2H)-one, GLYCEROL, ...
Authors:Oliver, A.W.
Deposit date:2014-07-28
Release date:2015-07-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Design and discovery of 3-aryl-5-substituted-isoquinolin-1- ones as potent and selective tankyrase inhibitors
To be published
2BRF
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BU of 2brf by Molmil
Crystal Structure of the FHA Domain of Human Polynucleotide Kinase 3' Phosphatase
Descriptor: BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, SULFATE ION
Authors:Oliver, A.W, Ali, A.A.E, Pearl, L.H.
Deposit date:2005-05-04
Release date:2005-05-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk.
Nucleic Acids Res., 37, 2009
2W3O
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BU of 2w3o by Molmil
Crystal structure of the human PNKP FHA domain in complex with an XRCC1-derived phosphopeptide
Descriptor: BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, CALCIUM ION, DNA REPAIR PROTEIN XRCC1
Authors:Oliver, A.W, Ali, A.A.E, Pearl, L.H.
Deposit date:2008-11-13
Release date:2009-02-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk.
Nucleic Acids Res., 37, 2009
5MG8
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BU of 5mg8 by Molmil
Crystal structure of the S.pombe Smc5/6 hinge domain
Descriptor: GLYCEROL, SULFATE ION, Structural maintenance of chromosomes protein 5, ...
Authors:Alt, A, Pearl, L.H, Oliver, A.W.
Deposit date:2016-11-21
Release date:2017-02-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Specialized interfaces of Smc5/6 control hinge stability and DNA association.
Nat Commun, 8, 2017
7AUD
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BU of 7aud by Molmil
Structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Bloom syndrome protein,Bloom syndrome protein, DNA (5'-D(*GP*TP*AP*CP*CP*CP*GP*AP*TP*GP*TP*GP*T)-3'), ...
Authors:Chen, X, Oliver, A.W.
Deposit date:2020-11-02
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.
Elife, 10, 2021
7AUC
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BU of 7auc by Molmil
Crystal structure of an engineered helicase domain construct for human Bloom syndrome protein (BLM)
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Chen, X, Oliver, A.W.
Deposit date:2020-11-02
Release date:2020-12-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.
Elife, 10, 2021
7AKO
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BU of 7ako by Molmil
Crystal structure of CHK1 kinase domain in complex with a CLASPIN phosphopeptide
Descriptor: 1,2-ETHANEDIOL, Claspin, STAUROSPORINE, ...
Authors:Day, M, Oliver, A.W, Pearl, L.H.
Deposit date:2020-10-01
Release date:2021-04-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein.
Structure, 29, 2021
7AKM
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BU of 7akm by Molmil
Crystal structure of CHK1 kinase domain in complex with ATPyS
Descriptor: 1,2-ETHANEDIOL, CITRIC ACID, MAGNESIUM ION, ...
Authors:Day, M, Oliver, A.W, Pearl, L.H.
Deposit date:2020-10-01
Release date:2021-04-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein.
Structure, 29, 2021
2XNH
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BU of 2xnh by Molmil
Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1
Descriptor: DNA TOPOISOMERASE 2-BINDING PROTEIN 1, IODIDE ION
Authors:Rappas, M, Oliver, A.W, Pearl, L.H.
Deposit date:2010-08-02
Release date:2010-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1.
Nucleic Acids Res., 39, 2011
2XNK
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BU of 2xnk by Molmil
Structure and function of the Rad9-binding region of the DNA damage checkpoint adaptor TopBP1
Descriptor: DNA TOPOISOMERASE 2-BINDING PROTEIN 1, GLYCEROL
Authors:Rappas, M, Oliver, A.W, Pearl, L.H.
Deposit date:2010-08-03
Release date:2010-09-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and Function of the Rad9-Binding Region of the DNA-Damage Checkpoint Adaptor Topbp1.
Nucleic Acids Res., 39, 2011
7P0L
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BU of 7p0l by Molmil
Crystal structure of S.pombe Mdb1 BRCT domains in complex with a H2A phosphopeptide
Descriptor: DNA damage response protein Mdb1, Histone H2A-beta
Authors:Day, M, Oliver, A.W, Pearl, L.H.
Deposit date:2021-06-29
Release date:2021-12-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1.
DNA Repair (Amst), 108, 2021
7P0J
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BU of 7p0j by Molmil
Crystal structure of S.pombe Mdb1 BRCT domains
Descriptor: CITRIC ACID, DNA damage response protein Mdb1, MAGNESIUM ION, ...
Authors:Day, M, Oliver, A.W, Pearl, L.H.
Deposit date:2021-06-29
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1.
DNA Repair (Amst), 108, 2021
5HY6
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BU of 5hy6 by Molmil
Spodoptera frugiperda eukaryotic translation initiation factor EIF5A
Descriptor: Eukaryotic translation initiation factor 5A
Authors:Li, A.W.H, Oliver, A.W, Pearl, L.H.
Deposit date:2016-02-01
Release date:2016-02-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.186 Å)
Cite:Structure of Spodoptera frugiperda eukaryotic translation initiation factor EIF5A
To Be Published
6RML
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BU of 6rml by Molmil
Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide
Descriptor: 53BP1, DNA topoisomerase 2-binding protein 1
Authors:Day, M, Oliver, A.W, Pearl, L.H.
Deposit date:2019-05-07
Release date:2019-06-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Elife, 8, 2019
6RMM
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BU of 6rmm by Molmil
Crystal structure of TOPBP1 BRCT4,5 in complex with a 53BP1 phosphopeptide
Descriptor: 53BP1, DNA topoisomerase 2-binding protein 1
Authors:Day, M, Oliver, A.W, Pearl, L.H.
Deposit date:2019-05-07
Release date:2019-06-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.53 Å)
Cite:Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint.
Elife, 8, 2019
7Z6H
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BU of 7z6h by Molmil
Structure of DNA-bound human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp
Descriptor: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1,Cell cycle checkpoint protein RAD17, Checkpoint protein HUS1, ...
Authors:Day, M, Oliver, A.W, Pearl, L.H.
Deposit date:2022-03-11
Release date:2022-05-04
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structure of the human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp bound to a dsDNA-ssDNA junction.
Nucleic Acids Res., 50, 2022
7QCD
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BU of 7qcd by Molmil
CryoEM structure of the Smc5/6-holocomplex (composite structure)
Descriptor: E3 SUMO-protein ligase MMS21, Non-structural maintenance of chromosome element 3, Non-structural maintenance of chromosome element 4, ...
Authors:Hallett, S.T, Oliver, A.W.
Deposit date:2021-11-23
Release date:2022-09-21
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Cryo-EM structure of the Smc5/6 holo-complex.
Nucleic Acids Res., 50, 2022

 

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