Author results

3E54
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ARCHAEAL INTRON-ENCODED HOMING ENDONUCLEASE I-VDI141I COMPLEXED WITH DNA
Descriptor:RRNA intron-encoded endonuclease, DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DTP*DCP*DTP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(P*DGP*DGP*DTP*DAP*DGP*DCP*DCP*DAP*DA)-3'), ...
Authors:Nomura, N., Nomura, Y., Sussman, D., Stoddard, B.L.
Deposit date:2008-08-13
Release date:2008-12-30
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases
Nucleic Acids Res., 36, 2008
4YBQ
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RAT GLUT5 WITH FV IN THE OUTWARD-OPEN FORM
Descriptor:Solute carrier family 2, facilitated glucose transporter member 5, antibody Fv fragment light chain, ...
Authors:Nomura, N., Shimamura, T., Iwata, S.
Deposit date:2015-02-19
Release date:2015-10-07
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Structure and mechanism of the mammalian fructose transporter GLUT5
Nature, 526, 2015
6AAM
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CRYSTAL STRUCTURE OF TYK2 IN COMPLEX WITH PEFICITINIB
Descriptor:Non-receptor tyrosine-protein kinase TYK2, 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
Authors:Nomura, N., Tomimoto, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
5YOY
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CRYSTAL STRUCTURE OF THE HUMAN TUMOR NECROSIS FACTOR IN COMPLEX WITH GOLIMUMAB FV
Descriptor:Tumor necrosis factor, Golimumab light chain variable region, Golimumab heavy chain variable region
Authors:Ono, M., Horita, S., Sato, Y., Nomura, Y., Iwata, S., Nomura, N.
Deposit date:2017-10-31
Release date:2018-05-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.727 Å)
Cite:Structural basis for tumor necrosis factor blockade with the therapeutic antibody golimumab
Protein Sci., 27, 2018
6A93
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CRYSTAL STRUCTURE OF 5-HT2AR IN COMPLEX WITH RISPERIDONE
Descriptor:5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, CHOLESTEROL, ...
Authors:Kimura, T.K., Asada, H., Inoue, A., Kadji, F.M.N., Im, D., Mori, C., Arakawa, T., Hirata, K., Nomura, Y., Nomura, N., Aoki, J., Iwata, S., Shimamura, T.
Deposit date:2018-07-11
Release date:2019-02-13
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
Nat.Struct.Mol.Biol., 26, 2019
6A94
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CRYSTAL STRUCTURE OF 5-HT2AR IN COMPLEX WITH ZOTEPINE
Descriptor:5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 2-(3-chloranylbenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine, CHOLESTEROL, ...
Authors:Kimura, T.K., Asada, H., Inoue, A., Kadji, F.M.N., Im, D., Mori, C., Arakawa, T., Hirata, K., Nomura, Y., Nomura, N., Aoki, J., Iwata, S., Shimamura, T.
Deposit date:2018-07-11
Release date:2019-02-13
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
Nat.Struct.Mol.Biol., 26, 2019
5B8C
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HIGH RESOLUTION STRUCTURE OF THE HUMAN PD-1 IN COMPLEX WITH PEMBROLIZUMAB FV
Descriptor:Pembrolizumab light chain variable region (PemVL), Pembrolizumab heavy chain variable region (PemVH), Programmed cell death protein 1
Authors:Horita, S., Shimamura, T., Iwata, S., Nomura, N.
Deposit date:2016-06-14
Release date:2016-10-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.146 Å)
Cite:High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1
Sci Rep, 6, 2016
2Z4F
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SOLUTION STRUCTURE OF THE DISCOIDIN DOMAIN OF DDR2
Descriptor:Discoidin domain-containing receptor 2
Authors:Ichikawa, O., Osawa, M., Nishida, N., Goshima, N., Nomura, N., Shimada, I.
Deposit date:2007-06-16
Release date:2007-09-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of the collagen-binding mode of discoidin domain receptor 2
Embo J., 26, 2007
2DCH
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CRYSTAL STRUCTURE OF ARCHAEAL INTRON-ENCODED HOMING ENDONUCLEASE I-TSP061I
Descriptor:putative homing endonuclease, CHLORIDE ION, SULFATE ION
Authors:Nakayama, H., Tsuge, H., Shimamura, T., Miyano, M., Nomura, N., Sako, Y.
Deposit date:2006-01-06
Release date:2006-07-06
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: contribution of cross-domain polar networks to thermostability.
J.Mol.Biol., 365, 2007
3A1Y
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THE STRUCTURE OF ARCHAEAL RIBOSOMAL STALK P1/P0 COMPLEX
Descriptor:50S ribosomal protein P1 (L12P), Acidic ribosomal protein P0
Authors:Naganuma, T., Yao, M., Nomura, N., Yu, J., Uchiumi, T., Tanaka, I.
Deposit date:2009-04-25
Release date:2009-11-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural basis for translation factor recruitment to the eukaryotic/archaeal ribosomes
J.Biol.Chem., 285, 2010
3VG9
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CRYSTAL STRUCTURE OF HUMAN ADENOSINE A2A RECEPTOR WITH AN ALLOSTERIC INVERSE-AGONIST ANTIBODY AT 2.7 A RESOLUTION
Descriptor:Adenosine receptor A2a, antibody fab fragment light chain, antibody fab fragment heavy chain, ...
Authors:Hino, T., Arakawa, T., Iwanari, H., Yurugi-Kobayashi, T., Ikeda-Suno, C., Nakada-Nakura, Y., Kusano-Arai, O., Weyand, S., Shimamura, T., Nomura, N., Cameron, A.D., Kobayashi, T., Hamakubo, T., Iwata, S., Murata, T.
Deposit date:2011-08-04
Release date:2012-02-01
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
Nature, 482, 2012
3VGA
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CRYSTAL STRUCTURE OF HUMAN ADENOSINE A2A RECEPTOR WITH AN ALLOSTERIC INVERSE-AGONIST ANTIBODY AT 3.1 A RESOLUTION
Descriptor:Adenosine receptor A2a, antibody fab fragment light chain, antibody fab fragment heavy chain, ...
Authors:Hino, T., Arakawa, T., Iwanari, H., Yurugi-Kobayashi, T., Ikeda-Suno, C., Nakada-Nakura, Y., Kusano-Arai, O., Weyand, S., Shimamura, T., Nomura, N., Cameron, A.D., Kobayashi, T., Hamakubo, T., Iwata, S., Murata, T.
Deposit date:2011-08-04
Release date:2012-02-01
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
Nature, 482, 2012
4YB9
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CRYSTAL STRUCTURE OF THE BOVINE FRUCTOSE TRANSPORTER GLUT5 IN AN OPEN INWARD-FACING CONFORMATION
Descriptor:Solute carrier family 2, facilitated glucose transporter member 5
Authors:Verdon, G., Kang, H.J., Iwata, S., Drew, D.
Deposit date:2015-02-18
Release date:2015-10-14
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and mechanism of the mammalian fructose transporter GLUT5.
Nature, 526, 2015
6GV1
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CRYSTAL STRUCTURE OF E.COLI MULTIDRUG/H+ ANTIPORTER MDFA IN OUTWARD OPEN CONFORMATION WITH BOUND FAB FRAGMENT
Descriptor:Major Facilitator Superfamily multidrug/H+ antiporter MdfA from E.coli, Fab fragment YN1074 heavy chain, Fab fragment YN1074 light chain, ...
Authors:Nagarathinam, K., Parthier, C., Stubbs, M.T., Tanabe, M.
Deposit date:2018-06-20
Release date:2018-10-03
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Outward open conformation of a Major Facilitator Superfamily multidrug/H+antiporter provides insights into switching mechanism.
Nat Commun, 9, 2018
5XJM
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COMPLEX STRUCTURE OF ANGIOTENSIN II TYPE 2 RECEPTOR WITH FAB
Descriptor:Type-2 angiotensin II receptor,Soluble cytochrome b562,Type-2 angiotensin II receptor, FabH, FabL, ...
Authors:Asada, H., Horita, S., Shimamura, T., Iwata, S.
Deposit date:2017-05-02
Release date:2018-07-11
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
Nat. Struct. Mol. Biol., 25, 2018
5XLI
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STRUCTURE OF ANTI-ANGIOTENSIN II TYPE2 RECEPTOR ANTIBODY (D5711-4A03)
Descriptor:FabL, FabH
Authors:Asada, H., Horita, S., Iwata, S., Hirata, K.
Deposit date:2017-05-10
Release date:2018-07-11
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.696 Å)
Cite:Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog.
Nat. Struct. Mol. Biol., 25, 2018
5YFI
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CRYSTAL STRUCTURE OF THE ANTI-HUMAN PROSTAGLANDIN E RECEPTOR EP4 ANTIBODY FAB FRAGMENT
Descriptor:Light chain of Fab fragment, Heavy chain of Fab fragment, ZINC ION
Authors:Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Iwata, S., Kobayashi, T.
Deposit date:2017-09-21
Release date:2018-12-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.848 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
5YHL
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CRYSTAL STRUCTURE OF THE HUMAN PROSTAGLANDIN E RECEPTOR EP4 IN COMPLEX WITH FAB AND AN ANTAGONIST BR-DERIVATIVE
Descriptor:Prostaglandin E2 receptor EP4 subtype, Heavy chain of Fab fragment, Light chain of Fab fragment, ...
Authors:Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Iwata, S., Kobayashi, T.
Deposit date:2017-09-28
Release date:2018-12-05
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
5YWY
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CRYSTAL STRUCTURE OF THE HUMAN PROSTAGLANDIN E RECEPTOR EP4 IN COMPLEX WITH FAB AND ONO-AE3-208
Descriptor:Prostaglandin E2 receptor EP4 subtype,Prostaglandin E2 receptor EP4 subtype, Heavy chain of Fab fragment, Light chain of Fab fragment, ...
Authors:Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Iwata, S., Kobayashi, T.
Deposit date:2017-11-30
Release date:2018-12-05
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
6AAH
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CRYSTAL STRUCTURE OF JAK1 IN COMPLEX WITH PEFICITINIB
Descriptor:Tyrosine-protein kinase JAK1, 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
Authors:Amano, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
6AAJ
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CRYSTAL STRUCTURE OF JAK2 IN COMPLEX WITH PEFICITINIB
Descriptor:Tyrosine-protein kinase JAK2, 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
Authors:Amano, Y., Tateishi, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
6AAK
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CRYSTAL STRUCTURE OF JAK3 IN COMPLEX WITH PEFICITINIB
Descriptor:Tyrosine-protein kinase JAK3, 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
Authors:Amano, Y.
Deposit date:2018-07-18
Release date:2018-08-15
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Bioorg. Med. Chem., 26, 2018
2WUH
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CRYSTAL STRUCTURE OF THE DDR2 DISCOIDIN DOMAIN BOUND TO A TRIPLE- HELICAL COLLAGEN PEPTIDE
Descriptor:DISCOIDIN DOMAIN RECEPTOR 2, COLLAGEN PEPTIDE
Authors:Carafoli, F., Bihan, D., Stathopoulos, S., Konitsiotis, A.D., Kvansakul, M., Farndale, R.W., Leitinger, B., Hohenester, E.
Deposit date:2009-10-05
Release date:2009-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic Insight Into Collagen Recognition by Discoidin Domain Receptor 2
Structure, 17, 2009