Author results

1NCN
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THE RECEPTOR-BINDING DOMAIN OF HUMAN B7-2
Descriptor:T lymphocyte activation antigen CD86
Authors:Zhang, X., Schwartz, J.D., Almo, S.C., Nathenson, S.G.
Deposit date:2002-12-05
Release date:2003-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Receptor-Binding Domain of Human B7-2: Insights into Organization and Signaling
Proc.Natl.Acad.Sci.USA, 100, 2003
1DQT
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THE CRYSTAL STRUCTURE OF MURINE CTLA4 (CD152)
Descriptor:CYTOTOXIC T LYMPHOCYTE ASSOCIATED ANTIGEN 4, CHLORIDE ION, 1,2-ETHANEDIOL
Authors:Ostrov, D.A., Shi, W., Schwartz, J.C., Almo, S.C., Nathenson, S.G.
Deposit date:2000-01-05
Release date:2000-10-27
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of murine CTLA-4 and its role in modulating T cell responsiveness.
Science, 290, 2000
1I85
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CRYSTAL STRUCTURE OF THE CTLA-4/B7-2 COMPLEX
Descriptor:T LYMPHOCYTE ACTIVATION ANTIGEN CD86, CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 4
Authors:Schwartz, J.-C.D., Zhang, X., Fedorov, A.A., Nathenson, S.G., Almo, S.C.
Deposit date:2001-03-12
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
Nature, 410, 2001
1INQ
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STRUCTURE OF MINOR HISTOCOMPATIBILITY ANTIGEN PEPTIDE, H13A, COMPLEXED TO H2-DB
Descriptor:H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, BETA-2 MICROGLOBULIN, ...
Authors:Ostrov, D.A., Roden, M.M., Shi, W., Palmieri, E., Christianson, G.J., Mendoza, L., Villaflor, G., Tilley, D., Shastri, N., Grey, H., Almo, S.C., Roopenian, D., Nathenson, S.G.
Deposit date:2001-05-14
Release date:2002-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination.
J.Immunol., 168, 2002
1JUF
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STRUCTURE OF MINOR HISTOCOMPATIBILITY ANTIGEN PEPTIDE, H13B, COMPLEXED TO H2-DB
Descriptor:H2-Db major histocompatibility antigen, Beta-2-microglobulin, H13b peptide
Authors:Ostrov, D.A., Roden, M.M., Shi, W., Palmieri, E., Christianson, G.J., Mendoza, L., Villaflor, G., Tilley, D., Shastri, N., Grey, H., Almo, S.C., Roopenian, D.C., Nathenson, S.G.
Deposit date:2001-08-24
Release date:2002-03-20
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination.
J.Immunol., 168, 2002
1LD9
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THE THREE-DIMENSIONAL STRUCTURE OF AN H-2LD PEPTIDE COMPLEX EXPLAINS THE UNIQUE INTERACTION OF LD WITH BETA2M AND PEPTIDE
Descriptor:MHC CLASS I H-2LD HEAVY CHAIN, BETA-2 MICROGLOBULIN, NANO-PEPTIDE
Authors:Balendiran, G.K., Solheim, J.C., Young, A.C.M., Hansen, T.H., Nathenson, S.G., Sacchettini, J.C.
Deposit date:1997-04-24
Release date:1998-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide.
Proc.Natl.Acad.Sci.USA, 94, 1997
1NPU
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE PD-1
Descriptor:Programmed cell death protein 1
Authors:Zhang, X., Schwartz, J.-C.D., Guo, X., Cao, E., Chen, L., Zhang, Z.-Y., Nathenson, S.G., Almo, S.C., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2003-01-20
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analysis of the costimulatory receptor programmed death-1.
Immunity, 20, 2004
2IF7
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CRYSTAL STRUCTURE OF NTB-A
Descriptor:SLAM family member 6, CALCIUM ION, CHLORIDE ION
Authors:Cao, E., Ramagopal, U.A., Fedorov, A.A., Fedorov, E.V., Nathenson, S.G., Almo, S.C.
Deposit date:2006-09-20
Release date:2006-10-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:NTB-A Receptor Crystal Structure: Insights into Homophilic Interactions in the Signaling Lymphocytic Activation Molecule Receptor Family.
Immunity, 25, 2006
2MHA
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CRYSTAL STRUCTURE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I H-2KB MOLECULE CONTAINING A SINGLE VIRAL PEPTIDE: IMPLICATIONS FOR PEPTIDE BINDING AND T-CELL RECEPTOR RECOGNITION
Descriptor:CLASS I HISTOCOMPATIBILITY ANTIGEN (H-2KB) (ALPHA CHAIN), BETA 2-MICROGLOBULIN, VIRAL OCTAPEPTIDE ARG-GLY-TYR-VAL-TYR-GLN-GLY-LEU
Authors:Zhang, W., Young, A.C.M., Imarai, M., Nathenson, S.G., Sacchettini, J.C.
Deposit date:1993-07-21
Release date:1993-10-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.
Proc.Natl.Acad.Sci.USA, 89, 1992
2OYP
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T CELL IMMUNOGLOBULIN MUCIN-3 CRYSTAL STRUCTURE REVEALED A GALECTIN-9-INDEPENDENT BINDING SURFACE
Descriptor:Hepatitis A virus cellular receptor 2, SULFATE ION
Authors:Cao, E., Ramagopal, U.A., Fedorov, A.A., Fedorov, E.V., Nathenson, S.G., Almo, S.C.
Deposit date:2007-02-22
Release date:2007-04-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface
Immunity, 26, 2007
2PKD
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CRYSTAL STRUCTURE OF CD84: INSITE INTO SLAM FAMILY FUNCTION
Descriptor:SLAM family member 5, CHLORIDE ION
Authors:Yan, Q., Malashkevich, V.N., Fedorov, A., Cao, E., Lary, J.W., Cole, J.L., Nathenson, S.G., Almo, S.C.
Deposit date:2007-04-17
Release date:2007-06-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.043 Å)
Cite:Structure of CD84 provides insight into SLAM family function.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Q1M
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CRYSTAL STRUCTURE OF HUMAN GITRL
Descriptor:Tumor necrosis factor ligand superfamily member 18
Authors:Chattopadhyay, K., Ramagopal, U.A., Nathenson, S.G., Almo, S.C.
Deposit date:2007-05-24
Release date:2007-11-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
Proc.Natl.Acad.Sci.USA, 104, 2007
2QDN
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CRYSTAL STRUCTURE OF MOUSE GITRL
Descriptor:GITR ligand
Authors:Chattopadhyay, K., Ramagopal, U.A., Nathenson, S.G., Almo, S.C.
Deposit date:2007-06-21
Release date:2008-01-01
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2QE3
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CRYSTAL STRUCTURE OF HUMAN TL1A EXTRACELLULAR DOMAIN
Descriptor:TNF superfamily ligand TL1A, CHLORIDE ION
Authors:Zhan, C., Yan, Q., Patskovsky, Y., Shi, W., Toro, R., Bonanno, J., Nathenson, S.G., Almo, S.C.
Deposit date:2007-06-22
Release date:2007-07-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
2R30
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CRYSTAL STRUCTURE OF HUMAN GITRL MUTANT
Descriptor:Tumor necrosis factor ligand superfamily member 18
Authors:Chattopadhyay, K., Ramagopal, U.A., Nathenson, S.G., Almo, S.C.
Deposit date:2007-08-28
Release date:2007-11-13
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
Proc.Natl.Acad.Sci.USA, 104, 2007
2R32
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CRYSTAL STRUCTURE OF HUMAN GITRL VARIANT
Descriptor:GCN4-pII/Tumor necrosis factor ligand superfamily member 18 fusion protein, SULFATE ION
Authors:Chattopadhyay, K., Ramagopal, U.A., Nathenson, S.G., Almo, S.C.
Deposit date:2007-08-28
Release date:2007-11-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
Proc.Natl.Acad.Sci.USA, 104, 2007
2RJK
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CRYSTAL STRUCTURE OF HUMAN TL1A EXTRACELLULAR DOMAIN C95S MUTANT
Descriptor:TNF superfamily ligand TL1A
Authors:Zhan, C., Yan, Q., Patskovsky, Y., Shi, W., Ramagopal, U.A., Toro, R., Bonanno, J., Nathenson, S.G., Almo, S.C.
Deposit date:2007-10-15
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
2RJL
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CRYSTAL STRUCTURE OF HUMAN TL1A EXTRACELLULAR DOMAIN C95S/C135S MUTANT
Descriptor:TNF superfamily ligand TL1A
Authors:Zhan, C., Patskovsky, Y., Yan, Q., Shi, W., Toro, R., Bonanno, J., Nathenson, S.G., Almo, S.C.
Deposit date:2007-10-15
Release date:2008-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
3B9I
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CRYSTAL STRUCTURE OF MOUSE GITRL AT 2.5 A.
Descriptor:GITR ligand
Authors:Chattopadhyay, K., Ramagopal, U.A., Nathenson, S.G., Almo, S.C.
Deposit date:2007-11-05
Release date:2008-01-01
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BOV
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CRYSTAL STRUCTURE OF THE RECEPTOR BINDING DOMAIN OF MOUSE PD-L2
Descriptor:Programmed cell death 1 ligand 2, SODIUM ION, FORMIC ACID
Authors:Lazar-Molnar, E., Ramagopal, U., Cao, E., Toro, R., Nathenson, S.G., Almo, S.C.
Deposit date:2007-12-17
Release date:2008-07-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.
Proc.Natl.Acad.Sci.USA, 105, 2008
3BP5
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CRYSTAL STRUCTURE OF THE MOUSE PD-1 AND PD-L2 COMPLEX
Descriptor:Programmed cell death protein 1, Programmed cell death 1 ligand 2, GLYCEROL
Authors:Yan, Q., Lazar-Molnar, E., Cao, E., Ramagopal, U.A., Toro, R., Nathenson, S.G., Almo, S.C.
Deposit date:2007-12-18
Release date:2008-07-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BP6
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CRYSTAL STRUCTURE OF THE MOUSE PD-1 MUTANT AND PD-L2 COMPLEX
Descriptor:Programmed cell death protein 1, Programmed cell death 1 ligand 2, GLYCEROL
Authors:Yan, Q., Lazar-Molnar, E., Cao, E., Ramagopal, U.A., Toro, R., Nathenson, S.G., Almo, S.C.
Deposit date:2007-12-18
Release date:2009-02-24
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the mouse PD-1 A99L and PD-L2 complex
To be published
3FC0
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1.8 A CRYSTAL STRUCTURE OF MURINE GITR LIGAND DIMER EXPRESSED IN DROSOPHILA MELANOGASTER S2 CELLS
Descriptor:GITR ligand, ACETATE ION
Authors:Chattopadhyay, K., Ramagopal, U.A., Nathenson, S.G., Almo, S.C.
Deposit date:2008-11-20
Release date:2008-12-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells.
Acta Crystallogr.,Sect.D, 65, 2009
3FOL
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CRYSTAL STRUCTURE OF THE CLASS I MHC MOLECULE H-2KWM7 WITH A SINGLE SELF PEPTIDE VNDIFERI
Descriptor:MHC, Beta-2-microglobulin, 8 residue synthetic peptide
Authors:Brims, D.R., Qian, J., Jarchum, I., Yamada, T., Mikesh, L., Palmieri, E., Lund, T., Hattori, M., Shabanowitz, J., Hunt, D.F., Ramagopal, U.A., Malashkevich, V.N., Almo, S.C., Nathenson, S.G., DiLorenzo, T.P.
Deposit date:2008-12-30
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect
Int.Immunol., 22, 2010
3FOM
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CRYSTAL STRUCTURE OF THE CLASS I MHC MOLECULE H-2KWM7 WITH A SINGLE SELF PEPTIDE IQQSIERL
Descriptor:MHC, Beta-2-microglobulin, 8 residue synthetic peptide, ...
Authors:Brims, D.R., Qian, J., Jarchum, I., Yamada, T., Mikesh, L., Palmieri, E., Lund, T., Hattori, M., Shabanowitz, J., Hunt, D.F., Ramagopal, U.A., Malashkevich, V.N., Almo, S.C., Nathenson, S.G., DiLorenzo, T.P.
Deposit date:2008-12-30
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.
Int.Immunol., 22, 2010
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