3FOM

Crystal structure of the Class I MHC Molecule H-2Kwm7 with a Single Self Peptide IQQSIERL

Summary for 3FOM

• Entry DOI: 10.2210/pdb3fom/pdb
• Related: 3FOL 3FON
• Descriptor: MHC, Beta-2-microglobulin, 8 residue synthetic peptide, ... (5 entities in total)
• Functional Keywords: class i mhc, peptide complex, diabetes-protective effect, immune response, immunoglobulin domain, mhc i, secreted, immune system
• Biological source: Mus musculus (mouse); More
• Cellular location: Secreted: P01887
• Total number of polymer chains: 3
• Total formula weight: 44345.23

Authors

Brims, D.R.,Qian, J.,Jarchum, I.,Yamada, T.,Mikesh, L.,Palmieri, E.,Lund, T.,Hattori, M.,Shabanowitz, J.,Hunt, D.F.,Ramagopal, U.A.,Malashkevich, V.N.,Almo, S.C.,Nathenson, S.G.,DiLorenzo, T.P. (deposition date: 2008-12-30, release date: 2010-01-12, Last modification date: 2017-11-01)

• Primary citation: Brims, D.R.,Qian, J.,Jarchum, I.,Mikesh, L.,Palmieri, E.,Ramagopal, U.A.,Malashkevich, V.N.,Chaparro, R.J.,Lund, T.,Hattori, M.,Shabanowitz, J.,Hunt, D.F.,Nathenson, S.G.,Almo, S.C.,Dilorenzo, T.P.; Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect.; Int.Immunol., 22:191-203, 2010; PubMed: 20093428; DOI: 10.1093/intimm/dxp127

Experimental method

X-RAY DIFFRACTION (2.1 Å)