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1OIA
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BU of 1oia by Molmil
U1A rnp domain 1-95
Descriptor: U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
Authors:Nagai, K, Evans, P.R.
Deposit date:2003-06-12
Release date:2003-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the RNA-Binding Domain of the U1 Small Nuclear Ribonucleoprotein A
Nature, 348, 1990
4WZJ
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BU of 4wzj by Molmil
Spliceosomal U4 snRNP core domain
Descriptor: Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, ...
Authors:Leung, A.K.W, Nagai, K, Li, J.
Deposit date:2014-11-19
Release date:2015-01-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.
Nature, 473, 2011
3CW1
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BU of 3cw1 by Molmil
Crystal Structure of Human Spliceosomal U1 snRNP
Descriptor: Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, ...
Authors:Pomeranz Krummel, D.A, Oubridge, C, Leung, A.K, Li, J, Nagai, K.
Deposit date:2008-04-21
Release date:2009-03-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (5.493 Å)
Cite:Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
Nature, 458, 2009
3KL4
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BU of 3kl4 by Molmil
Recognition of a signal peptide by the signal recognition particle
Descriptor: Signal peptide of yeast dipeptidyl aminopeptidase B, Signal recognition 54 kDa protein
Authors:Janda, C.Y, Nagai, K, Li, J, Oubridge, C.
Deposit date:2009-11-06
Release date:2010-03-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Recognition of a signal peptide by the signal recognition particle.
Nature, 465, 2010
6QDV
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BU of 6qdv by Molmil
Human post-catalytic P complex spliceosome
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ...
Authors:Fica, S.M, Oubridge, C, Wilkinson, M.E, Newman, A.J, Nagai, K.
Deposit date:2019-01-03
Release date:2019-02-20
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.
Science, 363, 2019
4BGD
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BU of 4bgd by Molmil
Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Nguyen, T.H.D, Li, J, Nagai, K.
Deposit date:2013-03-25
Release date:2013-05-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of Brr2-Prp8 Interactions and Implications for U5 Snrnp Biogenesis and the Spliceosome Active Site
Structure, 21, 2013
1FHT
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BU of 1fht by Molmil
RNA-BINDING DOMAIN OF THE U1A SPLICEOSOMAL PROTEIN U1A117, NMR, 43 STRUCTURES
Descriptor: U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
Authors:Allain, F.H.-T, Gubser, C.C, Howe, P.W.A, Nagai, K, Neuhaus, D, Varani, G.
Deposit date:1996-02-21
Release date:1996-07-11
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding.
J.Mol.Biol., 257, 1996
5MPS
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BU of 5mps by Molmil
Structure of a spliceosome remodeled for exon ligation
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ...
Authors:Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K.
Deposit date:2016-12-18
Release date:2017-01-18
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
5MQ0
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BU of 5mq0 by Molmil
Structure of a spliceosome remodeled for exon ligation
Descriptor: 3'-EXON OF UBC4 PRE-MRNA, BOUND BY PRP22 HELICASE, 5'-EXON OF UBC4 PRE-MRNA, ...
Authors:Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K.
Deposit date:2016-12-19
Release date:2017-01-18
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (4.17 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
4PKD
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BU of 4pkd by Molmil
U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2
Descriptor: IMIDAZOLE, MAGNESIUM ION, U1 small nuclear ribonucleoprotein A,U1 small nuclear ribonucleoprotein 70 kDa, ...
Authors:Oubridge, C, Kondo, Y, van Roon, A.M, Nagai, K.
Deposit date:2014-05-14
Release date:2014-12-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
Elife, 4, 2015
1DUH
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BU of 1duh by Molmil
CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN IV OF E. COLI 4.5S RNA
Descriptor: 4.5S RNA DOMAIN IV, LUTETIUM (III) ION, MAGNESIUM ION, ...
Authors:Jovine, L, Hainzl, T, Oubridge, C, Scott, W.G, Li, J, Sixma, T.K, Wonacott, A, Skarzynski, T, Nagai, K.
Deposit date:2000-01-17
Release date:2000-05-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA.
Structure Fold.Des., 8, 2000
6EXN
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BU of 6exn by Molmil
Post-catalytic P complex spliceosome with 3' splice site docked
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, Intron lariat: UBC4 RNA, ...
Authors:Wilkinson, M.E, Fica, S.M, Galej, W.P, Norman, C.M, Newman, A.J, Nagai, K.
Deposit date:2017-11-08
Release date:2018-01-17
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
Science, 358, 2017
6G90
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BU of 6g90 by Molmil
Prespliceosome structure provides insight into spliceosome assembly and regulation (map A2)
Descriptor: 56 kDa U1 small nuclear ribonucleoprotein component, Cold sensitive U2 snRNA suppressor 1, Pre-mRNA-processing factor 39, ...
Authors:Plaschka, C, Lin, P.-C, Charenton, C, Nagai, K.
Deposit date:2018-04-10
Release date:2018-08-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Prespliceosome structure provides insights into spliceosome assembly and regulation.
Nature, 559, 2018
6QW6
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BU of 6qw6 by Molmil
Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution.
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Charenton, C, Wilkinson, M.E, Nagai, K.
Deposit date:2019-03-05
Release date:2019-04-17
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Mechanism of 5' splice site transfer for human spliceosome activation.
Science, 364, 2019
6QX9
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BU of 6qx9 by Molmil
Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, AdML pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Charenton, C, Wilkinson, M.E, Nagai, K.
Deposit date:2019-03-07
Release date:2019-04-17
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Mechanism of 5' splice site transfer for human spliceosome activation.
Science, 364, 2019
5GAO
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BU of 5gao by Molmil
Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP
Descriptor: Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Saccharomyces cerevisiae strain UOA_M2 chromosome 5 sequence, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5GAM
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BU of 5gam by Molmil
Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-02-03
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution
Nature, 530, 2016
5GAN
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BU of 5gan by Molmil
The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom
Descriptor: 13 kDa ribonucleoprotein-associated protein, GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-processing factor 31, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
1URN
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BU of 1urn by Molmil
U1A MUTANT/RNA COMPLEX + GLYCEROL
Descriptor: CHLORIDE ION, GLYCEROL, PROTEIN (U1A), ...
Authors:Oubridge, C, Ito, N, Evans, P.R, Teo, C.-H, Nagai, K.
Deposit date:1995-01-04
Release date:1996-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin.
Nature, 372, 1994
2K0A
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BU of 2k0a by Molmil
1H, 15N and 13C chemical shift assignments for Rds3 protein
Descriptor: Pre-mRNA-splicing factor RDS3, ZINC ION
Authors:Loening, N, van Roon, A, Yang, J, Nagai, K, Neuhaus, D.
Deposit date:2008-01-31
Release date:2008-07-22
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the U2 snRNP protein Rds3p reveals a knotted zinc-finger motif.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2MY1
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BU of 2my1 by Molmil
Solution structure of Bud31p
Descriptor: Pre-mRNA-splicing factor BUD31, ZINC ION
Authors:van Roon, A.M, Yang, J, Mathieu, D, Bermel, W, Nagai, K, Neuhaus, D.
Deposit date:2015-01-19
Release date:2015-03-11
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:(113) Cd NMR Experiments Reveal an Unusual Metal Cluster in the Solution Structure of the Yeast Splicing Protein Bud31p.
Angew.Chem.Int.Ed.Engl., 54, 2015
4I43
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BU of 4i43 by Molmil
Crystal structure of Prp8:Aar2 complex
Descriptor: A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8
Authors:Galej, W.P, Oubridge, C, Newman, A.J, Nagai, K.
Deposit date:2012-11-27
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Prp8 reveals active site cavity of the spliceosome.
Nature, 493, 2013
1D3B
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BU of 1d3b by Molmil
CRYSTAL STRUCTURE OF THE D3B SUBCOMPLEX OF THE HUMAN CORE SNRNP DOMAIN AT 2.0A RESOLUTION
Descriptor: CITRIC ACID, GLYCEROL, PROTEIN (SMALL NUCLEAR RIBONUCLEOPROTEIN ASSOCIATED PROTEIN B), ...
Authors:Kambach, C, Walke, S, Avis, J.M, De La Fortelle, E, Li, J, Nagai, K.
Deposit date:1998-12-22
Release date:1999-12-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.
Cell(Cambridge,Mass.), 96, 1999
2VRD
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BU of 2vrd by Molmil
THE STRUCTURE OF THE ZINC FINGER FROM THE HUMAN SPLICEOSOMAL PROTEIN U1C
Descriptor: U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C, ZINC ION
Authors:Muto, Y, Pomeranz-Krummel, D, Oubridge, C, Hernandez, H, Robinson, C, Neuhaus, D, Nagai, K.
Deposit date:2008-03-31
Release date:2008-04-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Structure and Biochemical Properties of the Human Spliceosomal Protein U1C
J.Mol.Biol., 341, 2004
4PJO
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BU of 4pjo by Molmil
Minimal U1 snRNP
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ETHANOL, ...
Authors:Kondo, Y, Oubridge, C, van Roon, A.M, Nagai, K.
Deposit date:2014-05-12
Release date:2014-12-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
Elife, 4, 2015

 

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