1OIA

U1A rnp domain 1-95

Replaces:  1NRC

Summary for 1OIA

• Entry DOI: 10.2210/pdb1oia/pdb
• Related: 1AUD 1CX0 1DRZ 1DZ5 1FHT 1M5K 1M5O 1M5P 1M5V 1NU4 1URN 2U1A 3UTR
• Descriptor: U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A (2 entities in total)
• Functional Keywords: ribonucleoprotein, nuclear protein, rna-binding
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus: P09012
• Total number of polymer chains: 2
• Total formula weight: 21893.44

Authors

Nagai, K.,Evans, P.R. (deposition date: 2003-06-12, release date: 2003-06-26, Last modification date: 2024-05-08)

Primary citation

Nagai, K.,Oubridge, C.,Jessen, T.H.,Li, J.,Evans, P.R.
Crystal Structure of the RNA-Binding Domain of the U1 Small Nuclear Ribonucleoprotein A
Nature, 348:515-, 1990

PubMed Abstract: The crystal structure of the RNA binding domain of the U1 small nuclear ribonucleoprotein A, which forms part of the ribonucleoprotein complex involved in the excision of introns, has been solved. It contains a four-stranded beta sheet and two alpha helices. The highly conserved segments designated RNP1 and RNP2 lie side by side on the middle two beta strands. U1 RNA binding studies of mutant proteins suggest that the RNA binds to the four-stranded beta sheet and to the flexible loops on one end.

PubMed: 2147232
DOI: 10.1038/348515A0

Experimental method

X-RAY DIFFRACTION (2.4 Å)