Author results

5LKS
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STRUCTURE-FUNCTION INSIGHTS REVEAL THE HUMAN RIBOSOME AS A CANCER TARGET FOR ANTIBIOTICS
Descriptor:28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Myasnikov, A.G., Natchiar, S.K., Nebout, M., Hazemann, I., Imbert, V., Khatter, H., Peyron, J.-F., Klaholz, B.P.
Deposit date:2016-07-23
Release date:2017-04-26
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Nat Commun, 7, 2016
4V3P
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THE MOLECULAR STRUCTURE OF THE LEFT-HANDED SUPRA-MOLECULAR HELIX OF EUKARYOTIC POLYRIBOSOMES
Descriptor:G protein beta subunit, 40S ribosomal protein SA, Putative 40S ribosomal protein S3, ...
Authors:Myasnikov, A.G., Afonina, Z.A., Menetret, J.F., Shirokov, V.A., Spirin, A.S., Klaholz, B.P.
Deposit date:2014-10-20
Release date:2015-04-22
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (34 Å)
Cite:The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes.
Nat Commun, 5, 2014
1ML5
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STRUCTURE OF THE E. COLI RIBOSOMAL TERMINATION COMPLEX WITH RELEASE FACTOR 2
Descriptor:30S 16S RIBOSOMAL RNA, T-RNA(PHE), A- AND P-SITE MESSENGER RNA CODONS, ...
Authors:Klaholz, B.P., Pape, T., Zavialov, A.V., Myasnikov, A.G., Orlova, E.V., Vestergaard, B., Ehrenberg, M., van Heel, M.
Deposit date:2002-08-30
Release date:2003-01-14
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Structure of the Escherichia coli ribosomal termination complex with release factor 2
Nature, 421, 2003
2VAZ
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MODEL OF THE S15-MRNA COMPLEX FITTED INTO THE CRYO-EM MAP OF THE 70S ENTRAPMENT COMPLEX.
Descriptor:RPSO MRNA OPERATOR, 30S RIBOSOMAL PROTEIN S15
Authors:Marzi, S., Myasnikov, A.G., Serganov, A., Ehresmann, C., Romby, P., Yusupov, M., Klaholz, B.P.
Deposit date:2007-09-05
Release date:2007-10-02
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structured Mrnas Regulate Translation Initiation by Binding to the Platform of the Ribosome.
Cell(Cambridge,Mass.), 130, 2007
5K0Y
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M48S LATE-STAGE INITIATION COMPLEX, PURIFIED FROM RABBIT RETICULOCYTES LYSATES, DISPLAYING EIF2 TERNARY COMPLEX AND EIF3 I AND G SUBUNITS RELOCATED TO THE INTERSUBUNIT FACE
Descriptor:tRNA, 18S ribosomal RNA, mRNA, ...
Authors:Simonetti, A., Brito Querido, J., Myasnikov, A.G., Mancera-Martinez, E., Renaud, A., Kuhn, L., Hashem, Y.
Deposit date:2016-05-17
Release date:2016-07-13
Last modified:2018-04-18
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Mol.Cell, 63, 2016
5K1H
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EIF3B RELOCATED TO THE INTERSUBUNIT FACE TO INTERACT WITH EIF1 AND BELOW THE EIF2 TERNARY-COMPLEX. FROM THE STRUCTURE OF A PARTIAL YEAST 48S PREINITIATION COMPLEX IN CLOSED CONFORMATION.
Descriptor:Eukaryotic translation initiation factor 3 subunit B, eIF3a C-terminal tail
Authors:Simonetti, A., Brito Querido, J., Myasnikov, A.G., Mancera-Martinez, E., Renaud, A., Kuhn, L., Hashem, Y.
Deposit date:2016-05-18
Release date:2016-07-13
Last modified:2018-01-31
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Mol.Cell, 63, 2016
5OEJ
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STRUCTURE OF TRA1 SUBUNIT WITHIN THE CHROMATIN MODIFYING COMPLEX SAGA
Descriptor:Tra1 subunit within the chromatin modifying complex SAGA
Authors:Sharov, G., Voltz, K., Durand, A., Kolesnikova, O., Papai, G., Myasnikov, A.G., Dejaegere, A., Ben-Shem, A., Schultz, P.
Deposit date:2017-07-07
Release date:2017-08-02
Last modified:2017-11-29
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA.
Nat Commun, 8, 2017
6BQR
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HUMAN TRPM4 ION CHANNEL IN LIPID NANODISCS IN A CALCIUM-FREE STATE
Descriptor:Transient receptor potential cation channel subfamily M member 4, CHOLESTEROL HEMISUCCINATE
Authors:Autzen, H.E., Myasnikov, A.G., Campbell, M.G., Asarnow, D., Julius, D., Cheng, Y.
Deposit date:2017-11-28
Release date:2017-12-20
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of the human TRPM4 ion channel in a lipid nanodisc.
Science, 359, 2018
6BQV
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HUMAN TRPM4 ION CHANNEL IN LIPID NANODISCS IN A CALCIUM-BOUND STATE
Descriptor:Transient receptor potential cation channel subfamily M member 4, CALCIUM ION, CHOLESTEROL HEMISUCCINATE
Authors:Autzen, H.E., Myasnikov, A.G., Campbell, M.G., Asarnow, D., Julius, D., Cheng, Y.
Deposit date:2017-11-28
Release date:2017-12-20
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of the human TRPM4 ion channel in a lipid nanodisc.
Science, 359, 2018
6EK0
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HIGH-RESOLUTION CRYO-EM STRUCTURE OF THE HUMAN 80S RIBOSOME
Descriptor:28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Natchiar, S.K., Myasnikov, A.G., Kratzat, H., Hazemann, I., Klaholz, B.P.
Deposit date:2017-09-24
Release date:2018-01-24
Last modified:2019-05-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Visualization of chemical modifications in the human 80S ribosome structure.
Nature, 551, 2017
6QZP
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HIGH-RESOLUTION CRYO-EM STRUCTURE OF THE HUMAN 80S RIBOSOME
Descriptor:28S rRNA (3773-MER), 5S rRNA (120-MER), 5.8S rRNA (156-MER), ...
Authors:Natchiar, S.K., Myasnikov, A.G., Kratzat, H., Hazemann, I., Klaholz, B.P.
Deposit date:2019-03-12
Release date:2019-04-24
Last modified:2019-05-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:High-resolution cryo-EM structure of the human 80S ribosome
Nature, 551, 2017
3J4J
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MODEL OF FULL-LENGTH T. THERMOPHILUS TRANSLATION INITIATION FACTOR 2 REFINED AGAINST ITS CRYO-EM DENSITY FROM A 30S INITIATION COMPLEX MAP
Descriptor:Translation initiation factor IF-2
Authors:Simonetti, A., Marzi, S., Billas, I.M.L., Tsai, A., Fabbretti, A., Myasnikov, A., Roblin, P., Vaiana, A.C., Hazemann, I., Eiler, D., Steitz, T.A., Puglisi, J.D., Gualerzi, C.O., Klaholz, B.P.
Deposit date:2013-08-26
Release date:2013-09-25
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.
Proc.Natl.Acad.Sci.USA, 110, 2013
4UG0
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STRUCTURE OF THE HUMAN 80S RIBOSOME
Descriptor:28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Khatter, H., Myasnikov, A.G., Natchiar, S.K., Klaholz, B.P.
Deposit date:2015-03-20
Release date:2015-06-10
Last modified:2018-02-14
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of the human 80S ribosome
NATURE, 520, 2015
4B43
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BACTERIAL TRANSLATION INITIATION FACTOR IF2 (1-363), APO FORM, DOUBLE MUTANT K86L H130A
Descriptor:TRANSLATION INITIATION FACTOR IF-2, MAGNESIUM ION, GLYCEROL, ...
Authors:Simonetti, A., Urzhumtsev, A., Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-09-18
Method:X-RAY DIFFRACTION (1.937 Å)
Cite:Molecular Basis of GTP Hydrolysis by Bacterial Translation Initiation Factor If2
To be Published
4B44
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BACTERIAL TRANSLATION INITIATION FACTOR IF2 (1-363), COMPLEX WITH GDP AT PH8.0
Descriptor:TRANSLATION INITIATION FACTOR IF-2, GUANOSINE-5'-DIPHOSPHATE
Authors:Simonetti, A., Urzhumtsev, A., Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-09-18
Last modified:2015-02-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Basis of GTP Hydrolysis by Bacterial Translation Initiation Factor If2
To be Published
6FLP
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CRYOEM STRUCTURE OF E.COLI RNA POLYMERASE PAUSED ELONGATION COMPLEX WITHOUT RNA HAIRPIN BOUND TO NUSA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Guo, X., Weixlbaumer, A.
Deposit date:2018-01-26
Release date:2018-03-07
Last modified:2018-03-21
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural Basis for NusA Stabilized Transcriptional Pausing.
Mol. Cell, 69, 2018
6FLQ
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CRYOEM STRUCTURE OF E.COLI RNA POLYMERASE PAUSED ELONGATION COMPLEX BOUND TO NUSA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Guo, X., Weixlbaumer, A.
Deposit date:2018-01-26
Release date:2018-03-21
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural Basis for NusA Stabilized Transcriptional Pausing.
Mol. Cell, 69, 2018
6O81
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ELECTRON CRYO-MICROSCOPY OF THE EUKARYOTIC TRANSLATION INITIATION FACTOR 2B BOUND TO TRANSLATION INITIATION FACTOR 2 FROM HOMO SAPIENS
Descriptor:Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ...
Authors:Nguyen, H., Kenner, L., Frost, A.
Deposit date:2019-03-08
Release date:2019-05-15
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Science, 364, 2019
6O85
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ELECTRON CRYO-MICROSCOPY OF THE EUKARYOTIC TRANSLATION INITIATION FACTOR 2B BOUND TO EUKARYOTIC TRANSLATION INITIATION FACTOR 2 FROM HOMO SAPIENS
Descriptor:Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ...
Authors:Nguyen, H.C., Kenner, L.R., Frost, A.S.
Deposit date:2019-03-08
Release date:2019-05-15
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Science, 364, 2019
6O9Z
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ELECTRON CRYO-MICROSCOPY OF THE EUKARYOTIC TRANSLATION INITIATION FACTOR 2B BOUND TO EUKARYOTIC TRANSLATION INITIATION FACTOR 2 FROM HOMO SAPIENS
Descriptor:Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ...
Authors:Nguyen, H.C., Kenner, L.R., Frost, A.S.
Deposit date:2019-03-15
Release date:2019-05-15
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Science, 364, 2019