Author results

1Z8Y
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MAPPING THE E2 GLYCOPROTEIN OF ALPHAVIRUSES
Descriptor:Spike glycoprotein E1, Spike glycoprotein E2, Capsid protein C
Authors:Mukhopadhyay, S., Zhang, W., Gabler, S., Chipman, P.R., Strauss, E.G., Strauss, J.H., Baker, T.S., Kuhn, R.J., Rossmann, M.G.
Deposit date:2005-03-31
Release date:2006-02-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Mapping the structure and function of the E1 and E2 glycoproteins in alphaviruses.
Structure, 14, 2006
2IIR
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ACETATE KINASE FROM A HYPOTHERMOPHILE THERMOTOGA MARITIMA
Descriptor:Acetate kinase
Authors:Mukhopadhyay, S., Hasson, M.S., Sanders, D.A.
Deposit date:2006-09-28
Release date:2007-09-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Acetate kinase from a hypothermophile Thermotoga maritima
To be Published
4FRR
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X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN FROM APLYSIA CALIFORNICA IN PRESENCE OF 3-((S)-AZETIDIN-2-YLMETHOXY)-5-((1S,2R)-2-(2-METHOXYETHYL)CYCLOPROPYL)PYRIDINE
Descriptor:Soluble acetylcholine receptor, 3-[(2S)-azetidin-2-ylmethoxy]-5-[(1S,2R)-2-(2-methoxyethyl)cyclopropyl]pyridine, GLYCEROL
Authors:Mukhopadhyay, S., Mesecar, A.D.
Deposit date:2012-06-26
Release date:2013-10-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structure of Acetylcholine binding protein from Aplysia californica in presence of 3-((S)-azetidin-2-ylmethoxy)-5-((1S,2R)-2-(2-methoxyethyl)cyclopropyl)pyridine
To be Published
1P58
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COMPLEX ORGANIZATION OF DENGUE VIRUS MEMBRANE PROTEINS AS REVEALED BY 9.5 ANGSTROM CRYO-EM RECONSTRUCTION
Descriptor:Major envelope protein E, Envelope protein M
Authors:Zhang, W., Chipman, P.R., Corver, J., Johnson, P.R., Zhang, Y., Mukhopadhyay, S., Baker, T.S., Strauss, J.H., Rossmann, M.G., Kuhn, R.J.
Deposit date:2003-04-25
Release date:2003-11-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:Visualization of membrane protein domains by cryo-electron microscopy of dengue virus
Nat.Struct.Biol., 10, 2003
1NN8
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CRYOEM STRUCTURE OF POLIOVIRUS RECEPTOR BOUND TO POLIOVIRUS
Descriptor:poliovirus receptor, coat protein VP1, coat protein VP2, ...
Authors:He, Y., Mueller, S., Chipman, P.R., Bator, C.M., Peng, X., Bowman, V.D., Mukhopadhyay, S., Wimmer, E., Kuhn, R.J., Rossmann, M.G.
Deposit date:2003-01-13
Release date:2004-01-27
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (15 Å)
Cite:Complexes of poliovirus serotypes with their common cellular receptor, CD155
J.Virol., 77, 2003
4BW5
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1)
Descriptor:POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, CADMIUM ION, ...
Authors:Pike, A.C.W., Dong, Y.Y., Dong, L., Quigley, A., Shrestha, L., Mukhopadhyay, S., Strain-Damerell, C., Goubin, S., Grieben, M., Shintre, C.A., Mackenzie, A., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N., Carpenter, E.P.
Deposit date:2013-06-30
Release date:2013-07-31
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:K2P Channel Gating Mechanisms Revealed by Structures of Trek-2 and a Complex with Prozac
Science, 347, 2015
4TWK
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK1 (K2P2.1)
Descriptor:Potassium channel subfamily K member 2, POTASSIUM ION, Octyl Glucose Neopentyl Glycol, ...
Authors:Pike, A.C.W., Dong, Y.Y., Tessitore, A., Goubin, S., Strain-Damerell, C., Mukhopadhyay, S., Kupinska, K., Wang, D., Chalk, R., Berridge, G., Grieben, M., Shrestha, L., Ang, J.H., Mackenzie, A., Quigley, A., Bushell, S.R., Shintre, C.A., Faust, B., Chu, A., Dong, L., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P.
Deposit date:2014-06-30
Release date:2014-08-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)
To Be Published
4XDJ
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) IN AN ALTERNATE CONFORMATION (FORM 2)
Descriptor:POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Pike, A.C.W., Dong, Y.Y., Mackenzie, A., Mukhopadhyay, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2014-12-19
Release date:2015-03-18
Last modified:2015-04-01
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
4XDK
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) IN COMPLEX WITH NORFLUOXETINE
Descriptor:Potassium channel subfamily K member 10, POTASSIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Pike, A.C.W., Dong, Y.Y., Mackenzie, A., Mukhopadhyay, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2014-12-19
Release date:2015-03-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
4XDL
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CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK2 (K2P10.1) IN COMPLEX WITH A BROMINATED FLUOXETINE DERIVATIVE.
Descriptor:Potassium channel subfamily K member 10, POTASSIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Mackenzie, A., Pike, A.C.W., Dong, Y.Y., Mukhopadhyay, S., Ruda, G.F., Brennan, P.E., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2014-12-19
Release date:2015-03-18
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science, 347, 2015
5K47
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CRYOEM STRUCTURE OF THE HUMAN POLYCYSTIN-2/PKD2 TRP CHANNEL
Descriptor:Polycystin-2, N-ACETYL-D-GLUCOSAMINE
Authors:Pike, A.C.W., Grieben, M., Shintre, C.A., Tessitore, A., Shrestha, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Burgess-Brown, N.A., Huiskonen, J.T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2016-05-20
Release date:2016-08-24
Last modified:2018-10-10
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Nat. Struct. Mol. Biol., 24, 2017
5LEV
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CRYSTAL STRUCTURE OF HUMAN UDP-N-ACETYLGLUCOSAMINE-DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE (DPAGT1) (V264G MUTANT)
Descriptor:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, UNKNOWN LIGAND
Authors:Pike, A.C.W., Dong, Y.Y., Chu, A., Tessitore, A., Goubin, S., Dong, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Berridge, G., Wang, D., Kupinska, K., Belaya, K., Beeson, D., Burgess-Brown, N., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2016-06-30
Release date:2016-12-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant)(CASP target)
To Be Published
5O5E
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CRYSTAL STRUCTURE OF HUMAN UDP-N-ACETYLGLUCOSAMINE-DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE (DPAGT1) (V264G MUTANT) IN COMPLEX WITH TUNICAMYCIN
Descriptor:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Tunicamycin, ...
Authors:Pike, A.C.W., Dong, Y.Y., Chu, A., Tessitore, A., Goubin, S., Dong, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Berridge, G., Wang, D., Kupinska, K., Belaya, K., Beeson, D., Burgess-Brown, N., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-01
Release date:2018-02-28
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) in complex with tunicamycin
To Be Published
6FM9
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CRYSTAL STRUCTURE OF HUMAN UDP-N-ACETYLGLUCOSAMINE-DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE (DPAGT1)
Descriptor:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE
Authors:Pike, A.C.W., Dong, Y.Y., Chu, A., Tessitore, A., Goubin, S., Dong, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Berridge, G., Wang, D., Kupinska, K., Belaya, K., Beeson, D., Burgess-Brown, N., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2018-01-30
Release date:2018-02-28
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1)
To Be Published
6FWZ
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CRYSTAL STRUCTURE OF HUMAN UDP-N-ACETYLGLUCOSAMINE-DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE (DPAGT1) (V264G MUTANT) IN COMPLEX WITH UDP-GLCNAC
Descriptor:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, MAGNESIUM ION, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ...
Authors:Pike, A.C.W., Dong, Y.Y., Chu, A., Tessitore, A., Goubin, S., Dong, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Berridge, G., Wang, D., Kupinska, K., Belaya, K., Beeson, D., Burgess-Brown, N., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2018-03-07
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) in complex with UDP-GlcNAc
To Be Published
1K4R
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STRUCTURE OF DENGUE VIRUS
Descriptor:MAJOR ENVELOPE PROTEIN E
Authors:Kuhn, R.J., Zhang, W., Rossmann, M.G., Pletnev, S.V., Corver, J., Lenches, E., Jones, C.T., Mukhopadhyay, S., Chipman, P.R., Strauss, E.G., Baker, T.S., Strauss, J.H.
Deposit date:2001-10-08
Release date:2002-03-13
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (24 Å)
Cite:Structure of dengue virus: implications for flavivirus organization, maturation, and fusion.
Cell(Cambridge,Mass.), 108, 2002
1LD4
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PLACEMENT OF THE STRUCTURAL PROTEINS IN SINDBIS VIRUS
Descriptor:Coat protein C, GENERAL CONTROL PROTEIN GCN4, Spike glycoprotein E1, ...
Authors:Zhang, W., Mukhopadhyay, S., Pletnev, S.V., Baker, T.S., Kuhn, R.J., Rossmann, M.G.
Deposit date:2002-04-08
Release date:2002-11-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (11.4 Å)
Cite:Placement of the Structural Proteins in Sindbis virus
J.VIROL., 76, 2002
5C65
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STRUCTURE OF THE HUMAN GLUCOSE TRANSPORTER GLUT3 / SLC2A3
Descriptor:Solute carrier family 2, facilitated glucose transporter member 3, Octyl Glucose Neopentyl Glycol, ...
Authors:Pike, A.C.W., Quigley, A., Chu, A., Tessitore, A., Xia, X., Mukhopadhyay, S., Wang, D., Kupinska, K., Strain-Damerell, C., Chalk, R., Burgess-Brown, N.A., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2015-06-22
Release date:2015-07-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the human glucose transporter GLUT3 / SLC2A3
To Be Published
5OC9
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CRYSTAL STRUCTURE OF HUMAN TMEM16K / ANOCTAMIN 10
Descriptor:Anoctamin-10, CALCIUM ION, (2R)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate
Authors:Bushell, S.R., Pike, A.C.W., Chu, A., Tessitore, A., Rotty, B., Mukhopadhyay, S., Kupinska, K., Shrestha, L., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Love, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-29
Release date:2018-07-25
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structure of human TMEM16K / Anoctamin 10
TO BE PUBLISHED
5OCH
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THE CRYSTAL STRUCTURE OF HUMAN ABCB8 IN AN OUTWARD-FACING STATE
Descriptor:ATP-binding cassette sub-family B member 8, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Faust, B., Pike, A.C.W., Shintre, C.A., Quiqley, A.M., Chu, A., Barr, A., Shrestha, L., Mukhopadhyay, S., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The crystal structure of human ABCB8 in an outward-facing state
To Be Published
6GYN
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STRUCTURE OF HUMAN HCN4 HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED ION CHANNEL
Descriptor:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE
Authors:Shintre, C.A., Pike, A.C.W., Tessitore, A., Young, M., Bushell, S.R., Strain-Damerell, C., Mukhopadhyay, S., Burgess-Brown, N.A., Huiskonen, J.T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2018-06-30
Release date:2019-05-08
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
To Be Published
6GYO
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STRUCTURE OF HUMAN HCN4 HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED ION CHANNEL IN COMPLEX WITH CAMP
Descriptor:Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Shintre, C.A., Pike, A.C.W., Tessitore, A., Young, M., Bushell, S.R., Strain-Damerell, C., Mukhopadhyay, S., Burgess-Brown, N.A., Huiskonen, J.T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2018-06-30
Release date:2019-05-01
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
To Be Published
6R65
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CRYSTAL STRUCTURE OF HUMAN TMEM16K / ANOCTAMIN 10 (FORM 2)
Descriptor:Anoctamin-10, CALCIUM ION
Authors:Bushell, S.R., Pike, A.C.W., Chu, A., Tessitore, A., Rotty, B., Mukhopadhyay, S., Kupinska, K., Shrestha, L., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Love, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-26
Release date:2019-05-01
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal Structure of human TMEM16K / Anoctamin 10 (Form 2)
TO BE PUBLISHED
6R7X
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CRYOEM STRUCTURE OF CALCIUM-BOUND HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (2MM CA2+, CLOSED FORM)
Descriptor:Anoctamin-10, CALCIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Baronina, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (closed form)
TO BE PUBLISHED
6R7Y
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CRYOEM STRUCTURE OF CALCIUM-BOUND HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (LOW CA2+, CLOSED FORM)
Descriptor:Anoctamin-10, CALCIUM ION
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (closed form)
TO BE PUBLISHED
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