6YMQ

TREM2 extracellular domain (19-131) in complex with single-chain variable 4 (scFv-4)

This is a non-PDB format compatible entry.

Summary for 6YMQ

• Entry DOI: 10.2210/pdb6ymq/pdb
• Related: 6Y6C 6YMQ
• Descriptor: Single-chain variable 4, Triggering receptor expressed on myeloid cells 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: scfv, complex, receptor, alzheimer's, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 243322.31

Authors

Szykowska, A.,Preger, C.,Scacioc, A.,Mukhopadhyay, S.M.M.,McKinley, G.,Graslund, S.,Wigren, E.,Persson, H.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Di Daniel, E.,Davis, J.B.,Burgess-Brown, N.,Bullock, A. (deposition date: 2020-04-09, release date: 2021-02-17, Last modification date: 2024-01-31)

• Primary citation: Szykowska, A.,Chen, Y.,Smith, T.B.,Preger, C.,Yang, J.,Qian, D.,Mukhopadhyay, S.M.,Wigren, E.,Neame, S.J.,Graslund, S.,Persson, H.,Atkinson, P.J.,Di Daniel, E.,Mead, E.,Wang, J.,Davis, J.B.,Burgess-Brown, N.A.,Bullock, A.N.; Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain.; Structure, 29:1241-1252.e5, 2021; PubMed: 34233201; DOI: 10.1016/j.str.2021.06.010

Experimental method

X-RAY DIFFRACTION (3.07 Å)