6YMQ
TREM2 extracellular domain (19-131) in complex with single-chain variable 4 (scFv-4)
This is a non-PDB format compatible entry.
Summary for 6YMQ
Entry DOI | 10.2210/pdb6ymq/pdb |
Related | 6Y6C 6YMQ |
Descriptor | Single-chain variable 4, Triggering receptor expressed on myeloid cells 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | scfv, complex, receptor, alzheimer's, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 243322.31 |
Authors | Szykowska, A.,Preger, C.,Scacioc, A.,Mukhopadhyay, S.M.M.,McKinley, G.,Graslund, S.,Wigren, E.,Persson, H.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Di Daniel, E.,Davis, J.B.,Burgess-Brown, N.,Bullock, A. (deposition date: 2020-04-09, release date: 2021-02-17, Last modification date: 2024-01-31) |
Primary citation | Szykowska, A.,Chen, Y.,Smith, T.B.,Preger, C.,Yang, J.,Qian, D.,Mukhopadhyay, S.M.,Wigren, E.,Neame, S.J.,Graslund, S.,Persson, H.,Atkinson, P.J.,Di Daniel, E.,Mead, E.,Wang, J.,Davis, J.B.,Burgess-Brown, N.A.,Bullock, A.N. Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure, 29:1241-1252.e5, 2021 Cited by PubMed: 34233201DOI: 10.1016/j.str.2021.06.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.07 Å) |
Structure validation
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