4XDJ
Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in an alternate conformation (FORM 2)
Summary for 4XDJ
Entry DOI | 10.2210/pdb4xdj/pdb |
Related | 4BW5 |
Descriptor | POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (4 entities in total) |
Functional Keywords | transport protein, outward rectification, membrane protein, k2p, structural genomics, structural genomics consortium, sgc |
Biological source | homo sapiens (human) |
Cellular location | Membrane ; Multi-pass membrane protein : P57789 |
Total number of polymer chains | 4 |
Total formula weight | 128373.06 |
Authors | Pike, A.C.W.,Dong, Y.Y.,Mackenzie, A.,Mukhopadhyay, S.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Burgess-Brown, N.A.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (deposition date: 2014-12-19, release date: 2015-03-18, Last modification date: 2024-01-10) |
Primary citation | Dong, Y.Y.,Pike, A.C.,Mackenzie, A.,McClenaghan, C.,Aryal, P.,Dong, L.,Quigley, A.,Grieben, M.,Goubin, S.,Mukhopadhyay, S.,Ruda, G.F.,Clausen, M.V.,Cao, L.,Brennan, P.E.,Burgess-Brown, N.A.,Sansom, M.S.,Tucker, S.J.,Carpenter, E.P. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science, 347:1256-1259, 2015 Cited by PubMed: 25766236DOI: 10.1126/science.1261512 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.8 Å) |
Structure validation
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