4XDJ

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in an alternate conformation (FORM 2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005267	molecular_function	potassium channel activity
A	0016020	cellular_component	membrane
A	0071805	biological_process	potassium ion transmembrane transport
B	0005267	molecular_function	potassium channel activity
B	0016020	cellular_component	membrane
B	0071805	biological_process	potassium ion transmembrane transport
C	0005267	molecular_function	potassium channel activity
C	0016020	cellular_component	membrane
C	0071805	biological_process	potassium ion transmembrane transport
D	0005267	molecular_function	potassium channel activity
D	0016020	cellular_component	membrane
D	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue K A 601

Chain	Residue
A	ILE173
A	GLY174
A	VAL282
A	GLY283
A	K602
B	ILE173
B	GLY174
B	VAL282
B	GLY283

---

site_id	AC2
Number of Residues	10
Details	binding site for residue K A 602

Chain	Residue
A	THR172
A	ILE173
A	THR281
A	VAL282
A	K601
A	K603
B	THR172
B	ILE173
B	THR281
B	VAL282

---

site_id	AC3
Number of Residues	5
Details	binding site for residue K A 603

Chain	Residue
A	THR172
A	THR281
A	K602
B	THR172
B	THR281

---

site_id	AC4
Number of Residues	1
Details	binding site for residue PC1 A 604

Chain	Residue
A	PHE260

---

site_id	AC5
Number of Residues	3
Details	binding site for residue PC1 A 605

Chain	Residue
A	THR234
A	ARG237
A	LEU330

---

site_id	AC6
Number of Residues	3
Details	binding site for residue PC1 B 801

Chain	Residue
B	THR234
B	ARG237
B	TRP326

---

site_id	AC7
Number of Residues	3
Details	binding site for residue TRD B 802

Chain	Residue
B	THR171
B	THR172
B	ILE197

---

site_id	AC8
Number of Residues	1
Details	binding site for residue PC1 B 803

Chain	Residue
B	PHE260

---

site_id	AC9
Number of Residues	9
Details	binding site for residue K C 601

Chain	Residue
C	ILE173
C	GLY174
C	VAL282
C	GLY283
C	K602
D	ILE173
D	GLY174
D	VAL282
D	GLY283

---

site_id	AD1
Number of Residues	10
Details	binding site for residue K C 602

Chain	Residue
C	THR172
C	ILE173
C	THR281
C	VAL282
C	K601
C	K603
D	THR172
D	ILE173
D	THR281
D	VAL282

---

site_id	AD2
Number of Residues	5
Details	binding site for residue K C 603

Chain	Residue
C	THR172
C	THR281
C	K602
D	THR172
D	THR281

---

site_id	AD3
Number of Residues	2
Details	binding site for residue TRD C 604

Chain	Residue
C	THR281
C	PHE316

---

site_id	AD4
Number of Residues	1
Details	binding site for residue TRD D 401

Chain	Residue
D	THR172

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	320
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	104
Details	Intramembrane: {"description":"Pore-forming; Name=Pore-forming 1","evidences":[{"source":"PDB","id":"4BW5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	31
Details	Intramembrane: {"description":"Pore-forming; Name=Pore-forming 2","evidences":[{"source":"PDB","id":"4BW5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Region: {"description":"Selectivity filter 1","evidences":[{"source":"PubMed","id":"25766236","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Region: {"description":"Selectivity filter 2","evidences":[{"source":"PubMed","id":"25766236","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25766236","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XDK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"pH sensor","evidences":[{"source":"UniProtKB","id":"Q8BUW1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	30
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---