1K4R
Structure of Dengue Virus
Summary for 1K4R
| Entry DOI | 10.2210/pdb1k4r/pdb |
| Related | 1svb |
| Descriptor | MAJOR ENVELOPE PROTEIN E (1 entity in total) |
| Functional Keywords | flavivirus, flaviviridae, dengue virus, glycoprotein e from tick-borne encephalitis virus, icosahedral virus, virus |
| Biological source | Chimeric Tick-borne encephalitis virus/Dengue virus 4 |
| Total number of polymer chains | 3 |
| Total formula weight | 129693.43 |
| Authors | Kuhn, R.J.,Zhang, W.,Rossmann, M.G.,Pletnev, S.V.,Corver, J.,Lenches, E.,Jones, C.T.,Mukhopadhyay, S.,Chipman, P.R.,Strauss, E.G.,Baker, T.S.,Strauss, J.H. (deposition date: 2001-10-08, release date: 2002-03-13, Last modification date: 2024-10-30) |
| Primary citation | Kuhn, R.J.,Zhang, W.,Rossmann, M.G.,Pletnev, S.V.,Corver, J.,Lenches, E.,Jones, C.T.,Mukhopadhyay, S.,Chipman, P.R.,Strauss, E.G.,Baker, T.S.,Strauss, J.H. Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell(Cambridge,Mass.), 108:717-725, 2002 Cited by PubMed Abstract: The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane. PubMed: 11893341DOI: 10.1016/S0092-8674(02)00660-8 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (24 Å) |
Structure validation
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