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3CJZ
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BU of 3cjz by Molmil
Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m22G:A pairs
Descriptor: RNA (5'-R(*GP*GP*AP*CP*GP*(M2G)P*AP*CP*GP*UP*CP*CP*U)-3')
Authors:Pallan, P.S, Kreutz, C, Bosio, S, Micura, R, Egli, M.
Deposit date:2008-03-14
Release date:2008-10-14
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m2 2G:A pairs.
Rna, 14, 2008
7RQD
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BU of 7rqd by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MTI-tripeptidyl-tRNA analog ACCA-ITM, and chloramphenicol at 2.50A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S.
Deposit date:2021-08-06
Release date:2022-01-26
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.
Nat.Struct.Mol.Biol., 29, 2022
5DAT
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BU of 5dat by Molmil
Complex of yeast 80S ribosome with hypusine-containing eIF5A
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M.
Deposit date:2015-08-20
Release date:2016-08-31
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
To Be Published
3S8U
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BU of 3s8u by Molmil
Crystal structure of a 2-azido-adenine-modified RNA
Descriptor: Ecoli 23 S rRNA Sarcin Ricin loop
Authors:Ennifar, E, Micura, R.
Deposit date:2011-05-31
Release date:2012-04-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:2'-Azido RNA, a Versatile Tool for Chemical Biology: Synthesis, X-ray Structure, siRNA Applications, Click Labeling.
Acs Chem.Biol., 7, 2012
3S7C
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BU of 3s7c by Molmil
Crystal structure of a 2'-azido-uridine-modified RNA
Descriptor: Ecoli 23 S rRNA Sarcin Ricin loop
Authors:Ennifar, E, Micura, R.
Deposit date:2011-05-26
Release date:2012-04-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:2'-Azido RNA, a Versatile Tool for Chemical Biology: Synthesis, X-ray Structure, siRNA Applications, Click Labeling.
Acs Chem.Biol., 7, 2012
4Y27
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BU of 4y27 by Molmil
E.coli 23S Sarcin-Ricil Loop, modified with a 2-Me on G2661 and a methylphosphonate on A2662
Descriptor: 27-mer 23S Sarcin-Ricil Loop
Authors:Ennifar, E, Micura, R, Fluer, S.
Deposit date:2015-02-09
Release date:2015-11-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (0.998 Å)
Cite:Role of a ribosomal RNA phosphate oxygen during the EF-G-triggered GTP hydrolysis.
Proc.Natl.Acad.Sci.USA, 112, 2015
5NQI
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BU of 5nqi by Molmil
E.coli 16S rRNA Sarcin-Ricin Loop containing a 5-hydroxymethylcytosine modification
Descriptor: E.Coli 27-mer SRL RNA
Authors:Ennifar, E, Micura, R.
Deposit date:2017-04-20
Release date:2017-07-26
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (0.851 Å)
Cite:Synthesis, Thermodynamic Properties, and Crystal Structure of RNA Oligonucleotides Containing 5-Hydroxymethylcytosine.
J. Org. Chem., 82, 2017
1YKQ
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BU of 1ykq by Molmil
Crystal structure of Diels-Alder ribozyme
Descriptor: CADMIUM ION, Diels-Alder ribozyme, MAGNESIUM ION
Authors:Serganov, A, Keiper, S, Malinina, L, Tereshko, V, Skripkin, E, Hobartner, C, Polonskaia, A, Phan, A.T, Wombacher, R, Micura, R, Dauter, Z, Jaschke, A, Patel, D.J.
Deposit date:2005-01-18
Release date:2005-02-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
Nat.Struct.Mol.Biol., 12, 2005
1YKV
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BU of 1ykv by Molmil
Crystal structure of the Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene
Descriptor: (3AS,9AS)-2-PENTYL-4-HYDROXYMETHYL-3A,4,9,9A-TETRAHYDRO-4,9[1',2']-BENZENO-1H-BENZ[F]ISOINDOLE-1,3(2H)-DIONE, Diels-Alder ribozyme, MAGNESIUM ION
Authors:Serganov, A, Keiper, S, Malinina, L, Tereshko, V, Skripkin, E, Hobartner, C, Polonskaia, A, Phan, A.T, Wombacher, R, Micura, R, Dauter, Z, Jaschke, A, Patel, D.J.
Deposit date:2005-01-18
Release date:2005-02-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
Nat.Struct.Mol.Biol., 12, 2005
5DGF
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BU of 5dgf by Molmil
Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M.
Deposit date:2015-08-27
Release date:2016-12-14
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
To Be Published
5DGE
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BU of 5dge by Molmil
Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M.
Deposit date:2015-08-27
Release date:2017-01-25
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
To Be Published
5DC3
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BU of 5dc3 by Molmil
Complex of yeast 80S ribosome with non-modified eIF5A
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M.
Deposit date:2015-08-23
Release date:2016-06-01
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome.
J.Mol.Biol., 428, 2016
6XUS
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BU of 6xus by Molmil
RNA dodecamer with a 6-hydrazino-2-aminopurine modified base
Descriptor: MAGNESIUM ION, RNA dodecamer with a 6-hydrazino-2-aminopurine modified base, SODIUM ION
Authors:Ennifar, E, Micura, R, Gasser, C, Brillet, K.
Deposit date:2020-01-21
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Thioguanosine Conversion Enables mRNA-Lifetime Evaluation by RNA Sequencing Using Double Metabolic Labeling (TUC-seq DUAL).
Angew.Chem.Int.Ed.Engl., 59, 2020
6XUR
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BU of 6xur by Molmil
RNA dodecamer with a 6-hydrazino-2-aminopurine modified base
Descriptor: MAGNESIUM ION, RNA dodecamer with a 6-hydrazino-2-aminopurine modified base
Authors:Ennifar, E, Micura, R, Gasser, C, Brillet, K.
Deposit date:2020-01-21
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Thioguanosine Conversion Enables mRNA-Lifetime Evaluation by RNA Sequencing Using Double Metabolic Labeling (TUC-seq DUAL).
Angew.Chem.Int.Ed.Engl., 59, 2020
6N9E
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BU of 6n9e by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic CC-Pmn and bound to mRNA and P-site tRNA at 3.7A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S19, ...
Authors:Melnikov, S.V, Khabibullina, N.F, Mairhofer, E, Vargas-Rodriguez, O, Reynolds, N.M, Micura, R, Soll, D, Polikanov, Y.S.
Deposit date:2018-12-03
Release date:2018-12-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 47, 2019
6N9F
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BU of 6n9f by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S19, ...
Authors:Melnikov, S.V, Khabibullina, N.F, Mairhofer, E, Vargas-Rodriguez, O, Reynolds, N.M, Micura, R, Soll, D, Polikanov, Y.S.
Deposit date:2018-12-03
Release date:2018-12-12
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 47, 2019
8T8C
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BU of 8t8c by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R.
Deposit date:2023-06-22
Release date:2023-07-19
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics.
Acs Chem.Biol., 18, 2023
8T8B
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BU of 8t8b by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R.
Deposit date:2023-06-22
Release date:2023-07-19
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics.
Acs Chem.Biol., 18, 2023
5DUN
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BU of 5dun by Molmil
The crystal structure of OMe substituted twister ribozyme
Descriptor: MAGNESIUM ION, POTASSIUM ION, RNA (54-MER)
Authors:Ren, A, Patel, D.J, Micura, R, Rajashankar, K.R.
Deposit date:2015-09-19
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class.
Angew.Chem.Int.Ed.Engl., 54, 2015
5DGV
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BU of 5dgv by Molmil
Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog
Descriptor: 25S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M.
Deposit date:2015-08-28
Release date:2016-12-14
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
To Be Published
1YLS
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BU of 1yls by Molmil
Crystal structure of selenium-modified Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene
Descriptor: (3AS,9AS)-2-PENTYL-4-HYDROXYMETHYL-3A,4,9,9A-TETRAHYDRO-4,9[1',2']-BENZENO-1H-BENZ[F]ISOINDOLE-1,3(2H)-DIONE, MAGNESIUM ION, RNA Diels-Alder ribozyme
Authors:Serganov, A, Keiper, S, Malinina, L, Tereshko, V, Skripkin, E, Hobartner, C, Polonskaia, A, Phan, A.T, Wombacher, R, Micura, R, Dauter, Z, Jaschke, A, Patel, D.J.
Deposit date:2005-01-19
Release date:2005-02-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation.
Nat.Struct.Mol.Biol., 12, 2005
7QP2
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BU of 7qp2 by Molmil
1-deazaguanosine modified-RNA Sarcin Ricin Loop
Descriptor: GLYCEROL, RNA (27-MER)
Authors:Ennifar, E, Micura, R, Bereiter, R, Renard, E, Kreutz, C.
Deposit date:2021-12-30
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:1-Deazaguanosine-Modified RNA: The Missing Piece for Functional RNA Atomic Mutagenesis.
J.Am.Chem.Soc., 144, 2022
4NMG
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BU of 4nmg by Molmil
2'-Trifluoromethylthio-2'-deoxyuridine-modified SRL
Descriptor: 23S ribosomal RNA Sarcin Ricin Loop
Authors:Ennifar, E, Micura, R, Kosutic, M.
Deposit date:2013-11-15
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.01 Å)
Cite:Surprising base pairing and structural properties of 2'-trifluoromethylthio-modified ribonucleic acids.
J.Am.Chem.Soc., 136, 2014
4NLF
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BU of 4nlf by Molmil
2'-trifluoromethylthio-2'-deoxycytidine-modified SRL
Descriptor: 23S ribosomal RNA Sarcin Ricin Loop, SULFATE ION
Authors:Ennifar, E, Micura, R, Kosutic, M.
Deposit date:2013-11-14
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1 Å)
Cite:Surprising base pairing and structural properties of 2'-trifluoromethylthio-modified ribonucleic acids.
J.Am.Chem.Soc., 136, 2014
4NXH
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BU of 4nxh by Molmil
2'-Trifluoromethylthiouridine-modified E. coli 23S rRNA Sarcin Ricin Loop
Descriptor: 23S ribosomal RNA Sarcin Ricin Loop, GLYCEROL, SULFATE ION
Authors:Ennifar, E, Micura, R, Kosutic, M.
Deposit date:2013-12-09
Release date:2014-12-10
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.158 Å)
Cite:Surprising base pairing and structural properties of 2'-trifluoromethylthio-modified ribonucleic acids.
J.Am.Chem.Soc., 136, 2014

 

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