Author results

6XUR
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RNA DODECAMER WITH A 6-HYDRAZINO-2-AMINOPURINE MODIFIED BASE
Descriptor:RNA dodecamer with a 6-hydrazino-2-aminopurine modified base, MAGNESIUM ION
Authors:Ennifar, E., Micura, R., Gasser, C., Brillet, K.
Deposit date:2020-01-21
Release date:2020-02-19
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Thioguanosine conversion enables mRNA life-time evaluation by RNA sequencing via double metabolic labeling.
Angew.Chem.Int.Ed.Engl., 2020
6LAS
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THE WILDTYPE SAM-VI RIBOSWITCH BOUND TO SAM
Descriptor:RNA (55-MER), U1 small nuclear ribonucleoprotein A, S-ADENOSYLMETHIONINE
Authors:Ren, A., Sun, A.
Deposit date:2019-11-13
Release date:2020-01-01
Method:X-RAY DIFFRACTION (2.708 Å)
Cite:SAM-VI riboswitch structure and signature for ligand discrimination.
Nat Commun, 10, 2019
6LAU
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THE WILDTYPE SAM-VI RIBOSWITCH BOUND TO SAH
Descriptor:RNA (54-MER), U1 small nuclear ribonucleoprotein A, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Ren, A., Sun, A.
Deposit date:2019-11-13
Release date:2020-01-01
Method:X-RAY DIFFRACTION (3.109 Å)
Cite:SAM-VI riboswitch structure and signature for ligand discrimination.
Nat Commun, 10, 2019
6LAX
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THE MUTANT SAM-VI RIBOSWITCH (U6C) BOUND TO SAM
Descriptor:RNA (55-MER), U1 small nuclear ribonucleoprotein A, S-ADENOSYLMETHIONINE
Authors:Sun, A., Ren, A.
Deposit date:2019-11-13
Release date:2020-01-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:SAM-VI riboswitch structure and signature for ligand discrimination.
Nat Commun, 10, 2019
6LAZ
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THE WILDTYPE SAM-VI RIBOSWITCH BOUND TO A N-MUSTARD SAM ANALOG M1
Descriptor:RNA (55-MER), U1 small nuclear ribonucleoprotein A, MAGNESIUM ION, ...
Authors:Ren, A., Sun, A.
Deposit date:2019-11-13
Release date:2020-01-01
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:SAM-VI riboswitch structure and signature for ligand discrimination.
Nat Commun, 10, 2019
6UEY
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PISTOL RIBOZYME TRANSITION-STATE ANALOG VANADATE
Descriptor:RNA (50-MER), RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(GVA)*UP*CP*CP*AP*A)-3'), MAGNESIUM ION
Authors:Teplova, M., Falschlunger, C., Krasheninina, O., Patel, D.J., Micura, R.
Deposit date:2019-09-23
Release date:2019-12-18
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crucial Roles of Two Hydrated Mg2+Ions in Reaction Catalysis of the Pistol Ribozyme.
Angew.Chem.Int.Ed.Engl., 59, 2020
6UF1
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PISTOL RIBOZYME TRANSITION-STATE ANALOG VANADATE
Descriptor:RNA (50-MER), RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(GVA)*UP*CP*CP*AP*A)-3'), MANGANESE (II) ION
Authors:Teplova, M., Falschlunger, C., Krasheninina, O., Patel, D.J., Micura, R.
Deposit date:2019-09-23
Release date:2019-12-18
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crucial Roles of Two Hydrated Mg2+Ions in Reaction Catalysis of the Pistol Ribozyme.
Angew.Chem.Int.Ed.Engl., 59, 2020
6UFJ
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PISTOL RIBOZYME PRODUCT CRYSTAL STRUCTURE
Descriptor:RNA (50-MER), RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(23G))-3'), RNA (5'-R(*UP*CP*CP*AP*G)-3'), ...
Authors:Teplova, M., Falschlunger, C., Krasheninina, O., Patel, D.J., Micura, R.
Deposit date:2019-09-24
Release date:2019-12-18
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (2.645 Å)
Cite:Crucial Roles of Two Hydrated Mg2+Ions in Reaction Catalysis of the Pistol Ribozyme.
Angew.Chem.Int.Ed.Engl., 59, 2020
6UFK
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PISTOL RIBOZYME PRODUCT CRYSTAL SOAKED IN MN2+
Descriptor:RNA (50-MER), RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(23G))-3'), RNA (5'-R(*UP*CP*CP*AP*G)-3'), ...
Authors:Teplova, M., Falschlunger, C., Krasheninina, O., Patel, D.J., Micura, R.
Deposit date:2019-09-24
Release date:2019-12-18
Last modified:2020-02-19
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crucial Roles of Two Hydrated Mg2+Ions in Reaction Catalysis of the Pistol Ribozyme.
Angew.Chem.Int.Ed.Engl., 59, 2020
6QIQ
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CRYSTAL STRUCTURE OF SELENO-DERIVATIVE CAG REPEATS WITH SYNTHETIC CMBL3A COMPOUND
Descriptor:RNA (5'-R(*GP*CP*AP*G)-D(P*(CSL))-R(P*AP*GP*C)-3'), CMBL3a
Authors:Kiliszek, A., Blaszczyk, L., Rypniewski, W., Micura, R., Nakatani, K.
Deposit date:2019-01-21
Release date:2019-09-25
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.519 Å)
Cite:Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats.
Nucleic Acids Res., 47, 2019
6QIR
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CRYSTAL STRUCTURE OF CAG REPEATS WITH SYNTHETIC CMBL3A COMPOUND (MODEL I)
Descriptor:RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3'), CMBL3a
Authors:Kiliszek, A., Blaszczyk, L., Rypniewski, W., Nakatani, K.
Deposit date:2019-01-21
Release date:2019-09-25
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.531 Å)
Cite:Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats.
Nucleic Acids Res., 47, 2019
6QIS
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CRYSTAL STRUCTURE OF CAG REPEATS WITH SYNTHETIC CMBL3A COMPOUND (MODEL II)
Descriptor:RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3'), CMBL3a, SULFATE ION
Authors:Kiliszek, A., Blaszczyk, L., Rypniewski, W., Nakatani, K.
Deposit date:2019-01-21
Release date:2019-09-25
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats.
Nucleic Acids Res., 47, 2019
6QIT
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CRYSTAL STRUCTURE OF CAG REPEATS WITH SYNTHETIC CMBL3B COMPOUND
Descriptor:RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3'), CMBL3a
Authors:Kiliszek, A., Blaszczyk, L., Rypniewski, W., Nakatani, K.
Deposit date:2019-01-21
Release date:2019-09-25
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats.
Nucleic Acids Res., 47, 2019
6QIV
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CRYSTAL STRUCTURE OF SELENO-DERIVATIVE CAG REPEATS WITH SYNTHETIC CMBL4 COMPOUND
Descriptor:RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*C)-3'), CMBL4
Authors:Kiliszek, A., Blaszczyk, L., Rypniewski, W., Nakatani, K.
Deposit date:2019-01-21
Release date:2019-09-25
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats.
Nucleic Acids Res., 47, 2019
6JQ5
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THE STRUCTURE OF HATCHET RIBOZYME
Descriptor:RNA (82-MER), MAGNESIUM ION
Authors:Ren, A., Zheng, L.
Deposit date:2019-03-29
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.059 Å)
Cite:Hatchet ribozyme structure and implications for cleavage mechanism.
Proc.Natl.Acad.Sci.USA, 116, 2019
6JQ6
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HATCHET RIBOZYME STRUCTURE SOAKING WITH IR(NH3)6+
Descriptor:RNA (81-MER), IRIDIUM HEXAMMINE ION
Authors:Ren, A., Zheng, L.
Deposit date:2019-03-29
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.626 Å)
Cite:Hatchet ribozyme structure and implications for cleavage mechanism.
Proc.Natl.Acad.Sci.USA, 116, 2019
6N9E
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH A SHORT SUBSTRATE MIMIC CC-PMN AND BOUND TO MRNA AND P-SITE TRNA AT 3.7A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ...
Authors:Melnikov, S.V., Khabibullina, N.F., Mairhofer, E., Vargas-Rodriguez, O., Reynolds, N.M., Micura, R., Soll, D., Polikanov, Y.S.
Deposit date:2018-12-03
Release date:2018-12-12
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 47, 2019
6N9F
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH A SHORT SUBSTRATE MIMIC ACCA-DPHE AND BOUND TO MRNA AND P-SITE TRNA AT 3.7A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ...
Authors:Melnikov, S.V., Khabibullina, N.F., Mairhofer, E., Vargas-Rodriguez, O., Reynolds, N.M., Micura, R., Soll, D., Polikanov, Y.S.
Deposit date:2018-12-03
Release date:2018-12-12
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site.
Nucleic Acids Res., 47, 2019
5MRX
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27-NT SRL WITH A 5-HYDROXYMETHYL CYTIDINE MODIFICATION
Descriptor:RNA (27-MER)
Authors:Ennifar, E., Micura, R.
Deposit date:2016-12-28
Release date:2018-01-17
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (0.851 Å)
Cite:Xray structure of 5hmrc-modified RNA at atomic resolution
To Be Published
5Y85
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STRUCTURE-BASED INSIGHTS INTO SELF-CLEAVAGE BY A FOUR-WAY JUNCTIONAL TWISTER-SISTER RIBOZYME
Descriptor:RNA (5'-R(P*AP*CP*CP*CP*GP*CP*AP*AP*GP*GP*CP*CP*GP*AP*CP*GP*GP*C)-3'), DNA/RNA (50-MER), MAGNESIUM ION
Authors:Zheng, L., Micura, R.L., Ren, A.
Deposit date:2017-08-18
Release date:2017-11-22
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme
Nat Commun, 8, 2017
5Y87
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STRUCTURE-BASED INSIGHTS INTO SELF-CLEAVAGE BY A FOUR-WAY JUNCTIONAL TWISTER-SISTER RIBOZYME
Descriptor:RNA (5'-R(P*AP*CP*CP*CP*GP*CP*AP*AP*GP*GP*CP*CP*GP*AP*CP*GP*GP*C)-3'), DNA/RNA (50-MER), MANGANESE (II) ION
Authors:Zheng, L., Micura, R.L., Ren, A.
Deposit date:2017-08-19
Release date:2017-11-22
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.132 Å)
Cite:Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme
Nat Commun, 8, 2017
5VXB
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CRYSTAL STRUCTURE OF CAULOBACTER CRESCENTUS PROXP-ALA AT 1.69 ANGSTROM
Descriptor:ProXp-ala
Authors:Foster, M.P., Musier-Forsyth, K., Nakanishi, K., Ma, X.
Deposit date:2017-05-23
Release date:2017-08-09
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Conformational and chemical selection by a trans-acting editing domain.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NQI
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E.COLI 16S RRNA SARCIN-RICIN LOOP CONTAINING A 5-HYDROXYMETHYLCYTOSINE MODIFICATION
Descriptor:E.Coli 27-mer SRL RNA
Authors:Ennifar, E., Micura, R.
Deposit date:2017-04-20
Release date:2017-07-26
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (0.851 Å)
Cite:Synthesis, Thermodynamic Properties, and Crystal Structure of RNA Oligonucleotides Containing 5-Hydroxymethylcytosine.
J. Org. Chem., 82, 2017
5DGE
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COPING WITH PROLINE STALLING: STRUCTURAL BASIS OF HYPUSINE-INDUCED PROTEIN SYNTHESIS BY THE EUKARYOTIC RIBOSOME
Descriptor:18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Melnikov, S., Mailliot, J., Shin, B.-S., Rigger, L., Yusupova, G., Micura, R., Dever, T.E., Yusupov, M.
Deposit date:2015-08-27
Release date:2017-01-25
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
To Be Published
5TGM
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CRYSTAL STRUCTURE OF THE S.CEREVISIAE 80S RIBOSOME IN COMPLEX WITH THE A-SITE BOUND AMINOACYL-TRNA ANALOG ACCA-PRO
Descriptor:18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Melnikov, S., Mailliot, J., Yusupov, M.
Deposit date:2016-09-28
Release date:2017-01-18
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Molecular insights into protein synthesis with proline residues.
EMBO Rep., 17, 2016
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