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10MH
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TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET
Descriptor:DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*AP*GP*5NCP*GP*CP*AP*TP*GP*G)-3'), PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), ...
Authors:Sheikhnejad, G., Brank, A., Christman, J.K., Goddard, A., Alvarez, E., Ford Junior, H., Marquez, V.E., Marasco, C.J., Sufrin, J.R., O'Gara, M., Cheng, X.
Deposit date:1998-08-10
Release date:1999-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine.
J.Mol.Biol., 285, 1999
1ADF
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CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
Authors:Li, H., Hallows, W.A., Punzi, J.S., Marquez, V.E., Carrell, H.L., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
Deposit date:1993-10-18
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry, 33, 1994
1ADG
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CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN
Descriptor:ALCOHOL DEHYDROGENASE, ZINC ION, BETA-METHYLENE-SELENAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
Authors:Li, H., Hallows, W.A., Punzi, J.S., Marquez, V.E., Carrell, H.L., Pankiewicz, K.W., Watanabe, K.A., Goldstein, B.M.
Deposit date:1993-10-18
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry, 33, 1994
1KQN
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CRYSTAL STRUCTURE OF NMN/NAMN ADENYLYLTRANSFERASE COMPLEXED WITH NAD
Descriptor:NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, XENON
Authors:Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H.
Deposit date:2002-01-07
Release date:2003-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Human Nicotinamide/Nicotonic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
J.Biol.Chem., 277, 2003
1KQO
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CRYSTAL STRUCTURE OF NMN/NAMN ADENYLYLTRANSFERASE COMPLEXED WITH DEAMIDO-NAD
Descriptor:NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE, NICOTINIC ACID ADENINE DINUCLEOTIDE
Authors:Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H.
Deposit date:2002-01-07
Release date:2003-01-07
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Hhuman of Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
J.Biol.Chem., 277, 2002
1KR2
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CRYSTAL STRUCTURE OF HUMAN NMN/NAMN ADENYLYL TRANSFERASE COMPLEXED WITH TIAZOFURIN ADENINE DINUCLEOTIDE (TAD)
Descriptor:NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE, BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
Authors:Zhou, T., Kurnasov, O., Tomchick, D.R., Binns, D.D., Grishin, N.V., Marquez, V.E., Osterman, A.L., Zhang, H.
Deposit date:2002-01-08
Release date:2003-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of Hhuman of Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin.
J.Biol.Chem., 277, 2002
1OF1
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KINETICS AND CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (SOUTH)-METHANOCARBA-THYMIDINE
Descriptor:THYMIDINE KINASE, (SOUTH)-METHANOCARBA-THYMIDINE, SULFATE ION
Authors:Claus, M.T., Schelling, P., Folkers, G., Marquez, V.E., Scapozza, L., Schulz, G.E.
Deposit date:2003-04-03
Release date:2004-06-03
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Biochemical and Structural Characterization of (South)-Methanocarbathymidine that Specifically Inhibits Growth of Herpes Simplex Virus Type 1 Thymidine Kinase-Transduced Osteosarcoma Cells
J.Biol.Chem., 279, 2004
1OG1
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CRYSTAL STRUCTURE OF THE EUCARYOTIC MONO-ADP-RIBOSYLTRANSFERASE ART2.2 IN COMPLEX WITH TAD
Descriptor:T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 2, BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
Authors:Ritter, H., Koch-Nolte, F., Marquez, V.E., Schulz, G.E.
Deposit date:2003-04-23
Release date:2003-08-28
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Substrate Binding and Catalysis of Ecto-Adp-Ribosyltransferase 2.2 From Rat
Biochemistry, 42, 2003
1OG3
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CRYSTAL STRUCTURE OF THE EUKARYOTIC MONO-ADP-RIBOSYLTRANSFERASE ART2.2 MUTANT E189I IN COMPLEX WITH NAD
Descriptor:T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Ritter, H., Koch-Nolte, F., Marquez, V.E., Schulz, G.E.
Deposit date:2003-04-24
Release date:2003-08-28
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Substrate Binding and Catalysis of Ecto-Adp-Ribosyltransferase 2.2 From Rat
Biochemistry, 42, 2003
1OG4
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CRYSTAL STRUCTURE OF THE EUCARYOTIC MONO-ADP-RIBOSYLTRANSFERASE ART2.2 MUTANT E189A IN COMPLEX WITH NADH
Descriptor:T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 2, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE
Authors:Ritter, H., Koch-Nolte, F., Marquez, V.E., Schulz, G.E.
Deposit date:2003-04-24
Release date:2003-08-28
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Substrate Binding and Catalysis of Ecto-Adp-Ribosyltransferase 2.2 From Rat
Biochemistry, 42, 2003
1SKM
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HHAI METHYLTRANSFERASE IN COMPLEX WITH DNA CONTAINING AN ABASIC SOUTH CARBOCYCLIC SUGAR AT ITS TARGET SITE
Descriptor:5'-D(*TP*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*(HCX)P*GP*CP*AP*TP*GP*G)-3', Modification methylase HhaI, ...
Authors:Horton, J.R., Ratner, G., Banavali, N., Huang, N., Marquez, V.E., MacKerell, A.D., Cheng, X.
Deposit date:2004-03-05
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase
Nucleic Acids Res., 32, 2004
1ZM2
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STRUCTURE OF ADP-RIBOSYLATED EEF2 IN COMPLEX WITH CATALYTIC FRAGMENT OF ETA
Descriptor:Elongation factor 2, Exotoxin A, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Joergensen, R., Merrill, A.R., Yates, S.P., Marquez, V.E., Schwan, A.L., Boesen, T., Andersen, G.R.
Deposit date:2005-05-10
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
Nature, 436, 2005
1ZM3
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STRUCTURE OF THE APO EEF2-ETA COMPLEX
Descriptor:Elongation factor 2, exotoxin A
Authors:Joergensen, R., Merrill, A.R., Yates, S.P., Marquez, V.E., Schwan, A.L., Boesen, T., Andersen, G.R.
Deposit date:2005-05-10
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
Nature, 436, 2005
1ZM4
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STRUCTURE OF THE EEF2-ETA-BTAD COMPLEX
Descriptor:Elongation factor 2, exotoxin A, BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE
Authors:Joergensen, R., Merrill, A.R., Yates, S.P., Marquez, V.E., Schwan, A.L., Boesen, T., Andersen, G.R.
Deposit date:2005-05-10
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
Nature, 436, 2005
1ZM9
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STRUCTURE OF EEF2-ETA IN COMPLEX WITH PJ34
Descriptor:Elongation factor 2, exotoxin A, N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
Authors:Joergensen, R., Merrill, A.R., Yates, S.P., Marquez, V.E., Schwan, A.L., Boesen, T., Andersen, G.R.
Deposit date:2005-05-10
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
Nature, 436, 2005
388D
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CRYSTAL STRUCTURE OF B-DNA WITH INCORPORATED 2'-DEOXY-2'-FLUORO-ARABINO-FURANOSYL THYMINES: IMPLICATIONS OF CONFORMATIONAL PREORGANIZATION FOR DUPLEX STABILITY
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*(TAF)P*(TAF)P*CP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Berger, I., Tereshko, V., Ikeda, H., Marquez, V.E., Egli, M.
Deposit date:1998-04-20
Release date:1998-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stability.
Nucleic Acids Res., 26, 1998
389D
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CRYSTAL STRUCTURE OF B-DNA WITH INCORPORATED 2'-DEOXY-2'-FLUORO-ARABINO-FURANOSYL THYMINES: IMPLICATIONS OF CONFORMATIONAL PREORGANIZATION FOR DUPLEX STABILITY
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*(TAF)P*TP*CP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Berger, I., Tereshko, V., Ikeda, H., Marquez, V.E., Egli, M.
Deposit date:1998-04-20
Release date:1998-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stability.
Nucleic Acids Res., 26, 1998
3BUZ
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CRYSTAL STRUCTURE OF IA-BTAD-ACTIN COMPLEX
Descriptor:Iota toxin component Ia, Actin, alpha skeletal muscle, ...
Authors:Tsuge, H., Nagahama, M., Oda, M., Iwamoto, S., Utsunomiya, H., Marquez, V.E., Katunuma, N., Nishizawa, M., Sakurai, J.
Deposit date:2008-01-04
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens iota-toxin
Proc.Natl.Acad.Sci.Usa, 105, 2008
4DKZ
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HAIRPIN STRUCTURE OF A DNA DODECAMER CONTAINING NORTH-METHANOCARBA-2'-DEOXYTHYMIDINE
Descriptor:Synthetic DNA dodecamer containg North-methanocarba-2'-deoxythymidine (N-MCdT)
Authors:Egli, M., Pallan, P.S.
Deposit date:2012-02-05
Release date:2012-03-28
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Conformationally Constrained N-Methanocarba-dT Analogue Adopts an Unexpected C4'-exo Sugar Pucker in the Structure of a DNA Hairpin.
Biochemistry, 51, 2012
4EBC
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CONFORMATIONALLY RESTRAINED NORTH-METHANOCARBA-2'-DEOXYADENOSINE CORRECTS THE ERROR-PRONE NATURE OF HUMAN DNA POLYMERASE IOTA
Descriptor:DNA polymerase iota, 5'-D(P*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(P*CP*TP*GP*GP*GP*TP*CP*CP*T)-3', ...
Authors:Eoff, R.L., Ketkar, A., Banerjee, S.
Deposit date:2012-03-23
Release date:2012-06-13
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota.
J.Am.Chem.Soc., 134, 2012
4EBD
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CONFORMATIONALLY RESTRAINED NORTH-METHANOCARBA-2'-DEOXYADENOSINE CORRECTS THE ERROR-PRONE NATURE OF HUMAN DNA POLYMERASE IOTA
Descriptor:DNA polymerase iota, 5'-D(P*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(P*CP*TP*GP*GP*GP*TP*CP*CP*T)-3', ...
Authors:Eoff, R.L., Ketkar, A., Banerjee, S.
Deposit date:2012-03-23
Release date:2012-06-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.571 Å)
Cite:A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota.
J.Am.Chem.Soc., 134, 2012
4EBE
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CONFORMATIONALLY RESTRAINED NORTH-METHANOCARBA-2'-DEOXYADENOSINE CORRECTS THE ERROR-PRONE NATURE OF HUMAN DNA POLYMERASE IOTA
Descriptor:DNA polymerase iota, 5'-D(P*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(P*CP*TP*GP*GP*GP*TP*CP*CP*T)-3', ...
Authors:Eoff, R.L., Ketkar, A., Banerjee, S.
Deposit date:2012-03-23
Release date:2012-06-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota.
J.Am.Chem.Soc., 134, 2012
4GC6
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CRYSTAL STRUCTURE OF DPO4 IN COMPLEX WITH N-MC-DAMP OPPOSITE DT
Descriptor:DNA polymerase IV, DNA (5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*CP*C)-3'), DNA (5'-D(*TP*CP*AP*TP*GP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ...
Authors:Eoff, R.L., Ketkar, A., Banerjee, S., Zafar, M.K.
Deposit date:2012-07-29
Release date:2012-10-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.895 Å)
Cite:Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues.
Biochemistry, 51, 2012
4GC7
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CRYSTAL STRUCTURE OF DPO4 IN COMPLEX WITH S-MC-DADP OPPOSITE DT
Descriptor:DNA polymerase IV, DNA (5'-D(*G*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*CP*C)-3'), DNA (5'-D(*TP*CP*AP*TP*GP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), ...
Authors:Eoff, R.L., Ketkar, A., Banerjee, S., Zafar, M.K.
Deposit date:2012-07-29
Release date:2012-10-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues.
Biochemistry, 51, 2012
1NUP
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NAMN ADENYLYLTRANSFERASE COMPLEX WITH NMN
Descriptor:FKSG76, SULFATE ION, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE
Authors:Zhang, X., Kurnasov, O.V., Karthikeyan, S., Grishin, N.V., Osterman, A.L., Zhang, H.
Deposit date:2003-02-01
Release date:2003-06-03
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS
J.Biol.Chem., 278, 2003
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