1KR2

CRYSTAL STRUCTURE OF HUMAN NMN/NAMN ADENYLYL TRANSFERASE COMPLEXED WITH TIAZOFURIN ADENINE DINUCLEOTIDE (TAD)

Summary for 1KR2

Entry DOI	10.2210/pdb1kr2/pdb
Related	1KQN 1KQO
Descriptor	NICOTINAMIDE MONONUCLEOTIDE ADENYLYL TRANSFERASE, BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE (3 entities in total)
Functional Keywords	nucleotidyltransferase superfamily, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q9HAN9
Total number of polymer chains	6
Total formula weight	195899.89
Authors	Zhou, T.,Kurnasov, O.,Tomchick, D.R.,Binns, D.D.,Grishin, N.V.,Marquez, V.E.,Osterman, A.L.,Zhang, H. (deposition date: 2002-01-08, release date: 2003-01-08, Last modification date: 2024-04-03)
Primary citation	Zhou, T.,Kurnasov, O.,Tomchick, D.R.,Binns, D.D.,Grishin, N.V.,Marquez, V.E.,Osterman, A.L.,Zhang, H. Structure of Hhuman of Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin. J.Biol.Chem., 277:13148-13154, 2002 Cited by PubMed: 11788603 DOI: 10.1074/jbc.M111469200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation