1ADG

CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN

Summary for 1ADG

DescriptorALCOHOL DEHYDROGENASE, ZINC ION, BETA-METHYLENE-SELENAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE, ... (4 entities in total)
Functional Keywordsoxidoreductase(nad(a)-choh(d))
Biological sourceEquus caballus (horse)
Cellular locationCytoplasm P00327
Total number of polymer chains1
Total molecular weight40698.47
Authors
Li, H.,Hallows, W.A.,Punzi, J.S.,Marquez, V.E.,Carrell, H.L.,Pankiewicz, K.W.,Watanabe, K.A.,Goldstein, B.M. (deposition date: 1993-10-18, release date: 1994-01-31, Last modification date: 2017-11-29)
Primary citation
Li, H.,Hallows, W.H.,Punzi, J.S.,Marquez, V.E.,Carrell, H.L.,Pankiewicz, K.W.,Watanabe, K.A.,Goldstein, B.M.
Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry, 33:23-32, 1994
PubMed: 8286346 (PDB entries with the same primary citation)
DOI: 10.1021/bi00167a004
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers111.3%12.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 1adg
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Molmil generated image of 1adg
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1adg.pdb1.gz [142.54 KB])