4EBD

Conformationally Restrained North-methanocarba-2'-deoxyadenosine Corrects the Error-Prone Nature of Human DNA Polymerase Iota

Summary for 4EBD

• Entry DOI: 10.2210/pdb4ebd/pdb
• Related: 1T3N 2ALZ 3GV5 3GV7 3GV8 3H40 4EBC 4EBE
• Descriptor: DNA polymerase iota, 5'-D(P*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(P*CP*TP*GP*GP*GP*TP*CP*CP*T)-3', ... (7 entities in total)
• Functional Keywords: polymerase, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q9UNA4
• Total number of polymer chains: 3
• Total formula weight: 52647.18

Authors

Eoff, R.L.,Ketkar, A.,Banerjee, S. (deposition date: 2012-03-23, release date: 2012-06-13, Last modification date: 2023-09-13)

• Primary citation: Ketkar, A.,Zafar, M.K.,Banerjee, S.,Marquez, V.E.,Egli, M.,Eoff, R.L.; A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota.; J.Am.Chem.Soc., 134:10698-10705, 2012; PubMed: 22632140; DOI: 10.1021/ja304176q

Experimental method

X-RAY DIFFRACTION (2.571 Å)