1OF1

KINETICS AND CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (SOUTH)-METHANOCARBA-THYMIDINE

Summary for 1OF1

Entry DOI	10.2210/pdb1of1/pdb
Related	1E2H 1E2I 1E2J 1E2K 1E2L 1E2M 1E2N 1E2P 1KI2 1KI3 1KI4 1KI6 1KI7 1KI8 1QHI 1VTK 2KI5 3VTK
Descriptor	THYMIDINE KINASE, (SOUTH)-METHANOCARBA-THYMIDINE, SULFATE ION, ... (4 entities in total)
Functional Keywords	transferase, thymidine kinase, antiviral drug, enzyme-prodrug gene, kinase, dna synthesis, atp-binding
Biological source	HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17)
Total number of polymer chains	2
Total formula weight	82732.41
Authors	Claus, M.T.,Schelling, P.,Folkers, G.,Marquez, V.E.,Scapozza, L.,Schulz, G.E. (deposition date: 2003-04-03, release date: 2004-06-03, Last modification date: 2023-12-13)
Primary citation	Schelling, P.,Claus, M.T.,Johner, R.,Marquez, V.E.,Schulz, G.E.,Scapozza, L. Biochemical and Structural Characterization of (South)-Methanocarbathymidine that Specifically Inhibits Growth of Herpes Simplex Virus Type 1 Thymidine Kinase-Transduced Osteosarcoma Cells J.Biol.Chem., 279:32832-, 2004 Cited by PubMed: 15163659 DOI: 10.1074/JBC.M313343200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation