1E2K

Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine

Summary for 1E2K

• Entry DOI: 10.2210/pdb1e2k/pdb
• Related: 1E2H 1E2I 1E2J 1E2L 1E2M 1E2N 1E2P 1KI2 1KI4 1KI5 1KI6 1KI7 1KI8 1KIM 1VTK 2VTK 3VTK
• Descriptor: THYMIDINE KINASE, SULFATE ION, 1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE, ... (4 entities in total)
• Functional Keywords: transferase, thymidine kinase, antiviral drug, enzyme-prodrug gene therapy, sugar ring pucker
• Biological source: HERPES SIMPLEX VIRUS (TYPE 1/ STRAIN 17)
• Total number of polymer chains: 2
• Total formula weight: 72254.83

Authors

Vogt, J.,Scapozza, L.,Schulz, G.E. (deposition date: 2000-05-23, release date: 2000-08-19, Last modification date: 2023-12-06)

• Primary citation: Prota, A.,Vogt, J.,Pilger, B.,Perozzo, R.,Wurth, C.,Marquez, V.,Russ, P.,Schulz, G.E.,Folkers, G.,Scapozza, L.; Kinetics and Crystal Structure of the Wild-Type and the Engineered Y101F Mutant of Herpes Simplex Virus Type 1 Thymidine Kinase Interacting with (North)-Methanocarba-Thymidine; Biochemistry, 39:9597-, 2000; PubMed: 10924157; DOI: 10.1021/BI000668Q

Experimental method

X-RAY DIFFRACTION (1.7 Å)