1E2K

Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	THYMIDINE KINASE	polymer	331	35779.1	2	UniProt (P03176) Pfam (PF00693) UniProt (by SIFTS) (P0DTH5) In PDB	HERPES SIMPLEX VIRUS (TYPE 1/ STRAIN 17)
2	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	A, B	1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE	non-polymer		252.3	2	Chemie (TMC)
4		water	water		18.0	364	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71558.2
Non-Polymers*	Number of molecules	4
	Total formula weight	696.7
All*	Total formula weight	72254.8

*Water molecules are not included.