1E2I

The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography

Summary for 1E2I

• Entry DOI: 10.2210/pdb1e2i/pdb
• Related: 1E2H 1E2J 1E2K 1E2L 1E2M 1E2N 1E2P 1KI2 1KI4 1KI5 1KI6 1KI7 1KI8 1KIM 1VTK 2VTK 3VTK
• Descriptor: THYMIDINE KINASE, SULFATE ION, 9-HYDROXYPROPYLADENINE, S-ISOMER, ... (5 entities in total)
• Functional Keywords: transferase, adenine analog, enzyme-prodrug gene therapy, nucleoside- binding, thymidine kinase
• Biological source: HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17)
• Total number of polymer chains: 2
• Total formula weight: 72523.12

Authors

Vogt, J.,Scapozza, L.,Schulz, G.E. (deposition date: 2000-05-23, release date: 2000-11-06, Last modification date: 2023-12-06)

• Primary citation: Vogt, J.,Perozzo, R.,Pautsch, A.,Prota, A.,Schelling, P.,Pilger, B.,Folkers, G.,Scapozza, L.,Schulz, G.E.; Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography; Proteins, 41:545-, 2000; PubMed: 11056041; DOI: 10.1002/1097-0134(20001201)41:4<545::AID-PROT110>3.0.CO;2-8

Experimental method

X-RAY DIFFRACTION (1.9 Å)