1E2L

Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine

Summary for 1E2L

Entry DOI	10.2210/pdb1e2l/pdb
Related	1E2H 1E2I 1E2J 1E2K 1E2M 1E2N 1E2P 1KI2 1KI4 1KI5 1KI6 1KI7 1KI8 1KIM 1VTK 2VTK 3VTK
Descriptor	THYMIDINE KINASE, SULFATE ION, 1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE, ... (4 entities in total)
Functional Keywords	thymidine kinase, antiviral drug, enzyme-prodrug gene therapy, sugar ring pucker
Biological source	HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17)
Total number of polymer chains	2
Total formula weight	72222.83
Authors	Vogt, J.,Scapozza, L.,Schulz, G.E. (deposition date: 2000-05-23, release date: 2000-08-18, Last modification date: 2023-12-06)
Primary citation	Prota, A.,Vogt, J.,Pilger, B.,Perozzo, R.,Wurth, C.,Marquez, V.,Russ, P.,Schulz, G.E.,Folkers, G.,Scapozza, L. Kinetics and Crystal Structure of the Wild-Type and the Engineered Y101F Mutant of Herpes Simplex Virus Type 1 Thymidine Kinase Interacting with (North)-Methanocarba-Thymidine Biochemistry, 39:9597-, 2000 Cited by PubMed: 10924157 DOI: 10.1021/BI000668Q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation