1E2L
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004797 | molecular_function | thymidine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006230 | biological_process | TMP biosynthetic process |
B | 0004797 | molecular_function | thymidine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006230 | biological_process | TMP biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 400 |
Chain | Residue |
A | HIS58 |
A | GLY59 |
A | MET60 |
A | LYS62 |
A | THR63 |
A | ARG220 |
A | ARG222 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 B 400 |
Chain | Residue |
B | MET60 |
B | GLY61 |
B | LYS62 |
B | THR63 |
B | HOH2004 |
B | HIS58 |
B | GLY59 |
site_id | AC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE TMC A 500 |
Chain | Residue |
A | HIS58 |
A | GLU83 |
A | ILE97 |
A | GLN125 |
A | MET128 |
A | TYR132 |
A | ARG163 |
A | ALA168 |
A | TYR172 |
A | ARG222 |
A | HOH2077 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE TMC B 500 |
Chain | Residue |
B | HIS58 |
B | GLU83 |
B | ILE97 |
B | ILE100 |
B | GLN125 |
B | MET128 |
B | TYR132 |
B | ARG163 |
B | ALA168 |
B | TYR172 |
B | HOH2004 |
B | HOH2072 |
B | HOH2073 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_04029 |
Chain | Residue | Details |
A | GLU83 | |
B | GLU83 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04029 |
Chain | Residue | Details |
A | GLY56 | |
B | ARG222 | |
A | PHE101 | |
A | GLN125 | |
A | ARG216 | |
A | ARG222 | |
B | GLY56 | |
B | PHE101 | |
B | GLN125 | |
B | ARG216 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1kim |
Chain | Residue | Details |
A | GLU83 | |
A | ARG222 | |
A | GLY59 | |
A | ARG163 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1kim |
Chain | Residue | Details |
B | GLU83 | |
B | GLY59 | |
B | ARG163 |
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 588 |
Chain | Residue | Details |
A | LYS62 | electrostatic stabiliser, polar interaction |
A | GLU83 | proton acceptor, proton donor |
A | ASP162 | metal ligand |
A | ARG163 | electrostatic stabiliser, polar interaction |
A | ARG220 | electrostatic stabiliser, polar interaction |
A | ARG222 | electrostatic stabiliser, polar interaction |
A | GLU225 | electrostatic stabiliser, polar interaction |
site_id | MCSA2 |
Number of Residues | 7 |
Details | M-CSA 588 |
Chain | Residue | Details |
B | LYS62 | electrostatic stabiliser, polar interaction |
B | GLU83 | proton acceptor, proton donor |
B | ASP162 | metal ligand |
B | ARG163 | electrostatic stabiliser, polar interaction |
B | ARG220 | electrostatic stabiliser, polar interaction |
B | ARG222 | electrostatic stabiliser, polar interaction |
B | GLU225 | electrostatic stabiliser, polar interaction |