1E2L
Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | THYMIDINE KINASE | polymer | 331 | 35763.1 | 2 | UniProt (P03176) Pfam (PF00693) UniProt (by SIFTS) (P0DTH5) | HERPES SIMPLEX VIRUS (TYPE 1 / STRAIN 17) | |
| 2 | C, E (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D, F (A, B) | 1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE | non-polymer | 252.3 | 2 | Chemie (TMC) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
A, B: 46 - 376 (UniProt: P03176)
| PDB | External Database | Details |
|---|---|---|
| Phe 101 | Tyr 101 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71526.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 696.7 | |
| All* | Total formula weight | 72222.8 |
