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1DPL
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A-DNA DECAMER GCGTA(T23)TACGC WITH INCORPORATED 2'-METHOXY-3'-METHYLENEPHOSPHATE-THYMIDINE
Descriptor:5'-D(*GP*CP*GP*TP*AP*(T23)P*AP*CP*GP*C)-3', MAGNESIUM ION, SPERMINE
Authors:Egli, M., Tereshko, V., Teplova, M., Minasov, G., Joachimiak, A., Sanishvili, R., Weeks, C.M., Miller, R., Maier, M.A., An, H., Dan Cook, P., Manoharan, M.
Deposit date:1999-12-27
Release date:2000-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.83 Å)
Cite:X-ray crystallographic analysis of the hydration of A- and B-form DNA at atomic resolution.
Biopolymers, 48, 1998
1DPN
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B-DODECAMER CGCGAA(TAF)TCGCG WITH INCORPORATED 2'-DEOXY-2'-FLUORO-ARABINO-FURANOSYL THYMINE
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*(TAF)P*TP*CP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Egli, M., Tereshko, V., Teplova, M., Minasov, G., Joachimiak, A., Sanishvili, R., Weeks, C.M., Miller, R., Maier, M.A., An, H., Dan Cook, P., Manoharan, M.
Deposit date:1999-12-27
Release date:2000-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:X-ray crystallographic analysis of the hydration of A- and B-form DNA at atomic resolution.
Biopolymers, 48, 1998
1I0F
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1.6 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-AMINOOXYETHYL THYMINE IN PLACE OF T6, BA-FORM
Descriptor:5'-D(*GP*CP*GP*TP*AP*(127)P*AP*CP*GP*C)-3', BARIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0G
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1.45 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-FLUOROETHYL THYMINE IN PLACE OF T6, MEDIUM NA-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(125)P*AP*CP*GP*C)-3', SODIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0J
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1.06 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-3'-METHYLENEPHOSPHONATE (T23) THYMINE IN PLACE OF T6, HIGH CS-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(T23)P*AP*CP*GP*C)-3', CESIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0K
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1.05 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)] THYMINE IN PLACE OF T6, MEDIUM CS-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', CESIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0M
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1.05 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-FLUOROETHYL THYMINE IN PLACE OF T6, HIGH RB-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(125)P*AP*CP*GP*C)-3', RUBIDIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0N
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1.3 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)] THYMINE IN PLACE OF T6, MEDIUM RB-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', RUBIDIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0O
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1.6 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-3'-METHYLENEPHOSPHONATE THYMINE IN PLACE OF T6, HIGH K-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(T23)P*AP*CP*GP*C)-3', POTASSIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments
Nucleic Acids Res., 29, 2001
1I0P
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1.3 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)], MEDIUM K-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', POTASSIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0Q
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1.3 A STRUCTURE OF THE A-DECAMER GCGTATACGC WITH A SINGLE 2'-O-METHYL-[TRI(OXYETHYL)] THYMINE IN PLACE OF T6, MEDIUM NA-SALT
Descriptor:5'-D(*GP*CP*GP*TP*AP*(126)P*AP*CP*GP*C)-3', SODIUM ION
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1I0T
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0.6 A STRUCTURE OF Z-DNA CGCGCG
Descriptor:5'-D(*CP*GP*CP*GP*CP*G)-3', SPERMINE
Authors:Tereshko, V., Wilds, C.J., Minasov, G., Prakash, T.P., Maier, M.A., Howard, A., Wawrzak, Z., Manoharan, M., Egli, M.
Deposit date:2001-01-29
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.6 Å)
Cite:Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.
Nucleic Acids Res., 29, 2001
1KGK
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DIRECT OBSERVATION OF A CYTOSINE ANALOG THAT FORMS FIVE HYDROGEN BONDS TO GUANOSINE; GUANYL G-CLAMP
Descriptor:5'-D(*GP*(GCK)P*GP*TP*AP*TP*AP*CP*GP*C)-3', METHOXY-ETHOXYL, SPERMINE (FULLY PROTONATED FORM)
Authors:Wilds, C.J., Maier, M.A., Tereshko, V., Manoharan, M., Egli, M.
Deposit date:2001-11-27
Release date:2001-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:Direct Observation of a Cytosine Analogue that Forms Five Hydrogen Bonds to Guanosine: Guanidino G-Clamp
Angew.Chem.Int.Ed.Engl., 41, 2002
1SKM
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HHAI METHYLTRANSFERASE IN COMPLEX WITH DNA CONTAINING AN ABASIC SOUTH CARBOCYCLIC SUGAR AT ITS TARGET SITE
Descriptor:5'-D(*TP*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(*T*GP*TP*CP*AP*GP*(HCX)P*GP*CP*AP*TP*GP*G)-3', Modification methylase HhaI, ...
Authors:Horton, J.R., Ratner, G., Banavali, N., Huang, N., Marquez, V.E., MacKerell, A.D., Cheng, X.
Deposit date:2004-03-05
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase
Nucleic Acids Res., 32, 2004
2Q1O
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CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGC-NF2-AAUUGGCG, WITH AN INCORPORATED 2,4-DIFLUOROTOLUYL RESIDUE (NF2)
Descriptor:RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3')
Authors:Li, F., Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
2Q1R
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CRYSTAL STRUCTURE ANALYSIS OF THE RNA DODECAMER CGCGAAUUAGCG, WITH A G-A MISMATCH.
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3'), MAGNESIUM ION
Authors:Li, F., Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
3P4A
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2'FLUORO MODIFIED RNA OCTAMER FA2U2
Descriptor:2'Fluoro modified RNA 8-MER, STRONTIUM ION, MAGNESIUM ION
Authors:Manoharan, M., Akinc, A., Pandey, R.K., Qin, J., Hadwiger, P., John, M., Mills, K., Charisse, K., Maier, M.A., Nechev, L., Greene, E.M., Pallan, P.S., Rozners, E., Rajeev, K.G., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
5D8T
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RNA OCTAMER CONTAINING (S)-5' METHYL, 2'-F U.
Descriptor:RNA oligonucleotide containing (S)-C5'-Me-2'-FU, COBALT HEXAMMINE(III)
Authors:Harp, J.M., Egli, M.
Deposit date:2015-08-17
Release date:2016-06-29
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
5DEK
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RNA OCTAMER CONTAINING DT
Descriptor:RNA oligonucleotide containing dT, COBALT HEXAMMINE(III)
Authors:Harp, J.M., Egli, M.
Deposit date:2015-08-25
Release date:2016-07-20
Method:X-RAY DIFFRACTION (1.993 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
5DER
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RNA OLIGONUCLEOTIDE CONTAINING (R)-C5'-ME-2'F U
Descriptor:RNA oligonucleotide containing (R)-C5'-Me-2'-FU
Authors:Harp, J.M., Egli, M.
Deposit date:2015-08-25
Release date:2016-06-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
5V1K
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STRUCTURE OF R-GNA DODECAMER
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-02
Release date:2017-06-21
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 2017
5V1L
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STRUCTURE OF S-GNA DODECAMER
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), STRONTIUM ION, SPERMINE
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-02
Release date:2017-06-14
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
5V2H
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RNA OCTAMER CONTAINING GLYCOL NUCLEIC ACID, SGNT
Descriptor:RNA (5'-R(*(CBV)P*GP*AP*AP*(ZTH)P*UP*CP*G)-3'), COBALT HEXAMMINE(III), MAGNESIUM ION
Authors:Harp, J.M., Egli, M.
Deposit date:2017-03-04
Release date:2017-06-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.080013 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
6CXZ
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RNA OCTAMER CONTAINING 2'-F, 4'-CALPHA-ME U.
Descriptor:RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3'), CACODYLATE ION, COBALT HEXAMMINE(III)
Authors:Harp, J.M., Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY0
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RNA OCTAMER CONTAINING 2'-F, 4'-CBETA-OME U.
Descriptor:RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3')
Authors:Harp, J.M., Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
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