5V1L

Structure of S-GNA dodecamer

Summary for 5V1L

• Entry DOI: 10.2210/pdb5v1l/pdb
• Descriptor: RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), STRONTIUM ION, SPERMINE, ... (4 entities in total)
• Functional Keywords: glycol nucleic acid, gna, rna, rna x-ray structure, nuclease stability, modified rna
• Biological source: synthetic construct
• Total number of polymer chains: 4
• Total formula weight: 16132.70

Authors

Pallan, P.S.,Egli, M. (deposition date: 2017-03-02, release date: 2017-06-14, Last modification date: 2022-06-22)

• Primary citation: Schlegel, M.K.,Foster, D.J.,Kel'in, A.V.,Zlatev, I.,Bisbe, A.,Jayaraman, M.,Lackey, J.G.,Rajeev, K.G.,Charisse, K.,Harp, J.,Pallan, P.S.,Maier, M.A.,Egli, M.,Manoharan, M.; Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.; J. Am. Chem. Soc., 139:8537-8546, 2017; PubMed: 28570818; DOI: 10.1021/jacs.7b02694

Experimental method

X-RAY DIFFRACTION (1.2 Å)