Author results

5CP6
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NUCLEOSOME CORE PARTICLE WITH ADDUCTS FROM THE ANTICANCER COMPOUND, [(ETA6-5,8,9,10-TETRAHYDROANTHRACENE)RU(ETHYLENEDIAMINE)CL][PF6]
Descriptor:DNA (145-MER), Histone H3.2, Histone H4, ...
Authors:Ma, Z., Adhireksan, Z., Murray, B.S., Dyson, P.J., Davey, C.A.
Deposit date:2015-07-21
Release date:2016-06-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An Organometallic Compound which Exhibits a DNA Topology-Dependent One-Stranded Intercalation Mode.
Angew.Chem.Int.Ed.Engl., 55, 2016
5CHO
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CRYSTAL STRUCTURE OF BORF, THE FLAVIN REDUCTASE COMPONENT OF A BACTERIAL TWO-COMPONENT TRYPTOPHAN HALOGENASE
Descriptor:Flavin reductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Ma, Z., Bellizzi, J.
Deposit date:2015-07-10
Release date:2016-06-29
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Crystal Structure of BorF, the Flavin Reductase Component of a Bacterial Two-Component Tryptophan Halogenase
To be published
5XF3
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NUCLEOSOME CORE PARTICLE WITH AN ADDUCT OF A BINUCLEAR RAPTA (RU-ARENE-PHOSPHAADAMANTANE) COMPOUND HAVING A 1,2-DIPHENYLETHYLENEDIAMINE LINKER (R,R-CONFIGURATION)
Descriptor:Histone H3.1, Histone H4, Histone H2A type 1-B/E, ...
Authors:Ma, Z., Adhireksan, Z., Murray, B.S., Dyson, P.J., Davey, C.A.
Deposit date:2017-04-07
Release date:2017-10-11
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Nat Commun, 8, 2017
5XF4
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NUCLEOSOME CORE PARTICLE WITH AN ADDUCT OF A BINUCLEAR RAPTA (RU-ARENE-PHOSPHAADAMANTANE) COMPOUND HAVING A 1,2-DIPHENYLETHYLENEDIAMINE LINKER (S,S-CONFIGURATION)
Descriptor:Histone H3.1, Histone H4, Histone H2A type 1-B/E, ...
Authors:Ma, Z., Adhireksan, Z., Murray, B.S., Dyson, P.J., Davey, C.A.
Deposit date:2017-04-07
Release date:2017-10-11
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Nat Commun, 8, 2017
5XF5
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NUCLEOSOME CORE PARTICLE WITH AN ADDUCT OF A BINUCLEAR RAPTA (RU-ARENE-PHOSPHAADAMANTANE) COMPOUND HAVING A 1,2-DIPHENYLETHYLENEDIAMINE LINKER (R,S-CONFIGURATION)
Descriptor:Histone H3.1, Histone H4, Histone H2A type 1-B/E, ...
Authors:Ma, Z., Adhireksan, Z., Murray, B.S., Dyson, P.J., Davey, C.A.
Deposit date:2017-04-07
Release date:2017-10-11
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Nat Commun, 8, 2017
5XF6
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NUCLEOSOME CORE PARTICLE WITH AN ADDUCT OF A BINUCLEAR RAPTA (RU-ARENE-PHOSPHAADAMANTANE) COMPOUND HAVING AN ETHYLENEDIAMINE LINKER
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Ma, Z., Adhireksan, Z., Murray, B.S., Dyson, P.J., Davey, C.A.
Deposit date:2017-04-07
Release date:2017-10-11
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Nat Commun, 8, 2017
5DNN
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NUCLEOSOME CORE PARTICLE CONTAINING ADDUCTS OF GOLD(I)-TRIETHYLPHOSPHANE AND RUTHENIUM(II)-TOLUENE PTA COMPLEXES
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Adhireksan, Z., Ma, Z., Davey, C.A.
Deposit date:2015-09-10
Release date:2016-09-14
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric cross-talk in chromatin can mediate drug-drug synergy
Nat Commun, 8, 2017
1U3C
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CRYSTAL STRUCTURE OF THE PHR DOMAIN OF CRYPTOCHROME 1 FROM ARABIDOPSIS THALIANA
Descriptor:Cryptochrome 1 apoprotein, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Brautigam, C.A., Smith, B.S., Ma, Z., Palnitkar, M., Tomchick, D.R., Machius, M., Deisenhofer, J.
Deposit date:2004-07-21
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana.
Proc.Natl.Acad.Sci.USA, 101, 2004
1U3D
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CRYSTAL STRUCTURE OF THE PHR DOMAIN OF CRYPTOCHROME 1 FROM ARABIDOPSIS THALIANA WITH AMPPNP BOUND
Descriptor:Cryptochrome 1 apoprotein, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Brautigam, C.A., Smith, B.S., Ma, Z., Palnitkar, M., Tomchick, D.R., Machius, M., Deisenhofer, J.
Deposit date:2004-07-21
Release date:2004-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana.
Proc.Natl.Acad.Sci.USA, 101, 2004
1ZG1
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NARL COMPLEXED TO NIRB PROMOTER NON-PALINDROMIC TAIL-TO-TAIL DNA SITE
Descriptor:5'-D(*CP*GP*TP*AP*CP*TP*CP*CP*TP*TP*AP*AP*TP*GP*GP*GP*TP*AP*CP*G)-3', 5'-D(*CP*GP*TP*AP*CP*CP*CP*AP*TP*TP*AP*AP*GP*GP*AP*GP*TP*AP*CP*G)-3', Nitrate/nitrite response regulator protein narL, ...
Authors:Maris, A.E., Kaczor-Grzeskowiak, M., Ma, Z., Kopka, M.L., Gunsalus, R.P., Dickerson, R.E.
Deposit date:2005-04-20
Release date:2005-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Primary and Secondary Modes of DNA Recognition by the NarL Two-Component Response Regulator.
Biochemistry, 44, 2005
1ZG5
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NARL COMPLEXED TO NARG-89 PROMOTER PALINDROMIC TAIL-TO-TAIL DNA SITE
Descriptor:5'-D(*CP*GP*TP*AP*CP*CP*CP*CP*TP*AP*TP*AP*GP*GP*GP*GP*TP*AP*CP*G)-3', Nitrate/nitrite response regulator protein narL, SULFATE ION
Authors:Maris, A.E., Kaczor-Grzeskowiak, M., Ma, Z., Kopka, M.L., Gunsalus, R.P., Dickerson, R.E.
Deposit date:2005-04-20
Release date:2005-11-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Primary and Secondary Modes of DNA Recognition by the NarL Two-Component Response Regulator.
Biochemistry, 44, 2005
4GGG
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CRYSTAL STRUCTURE OF V66A/L68V CZRA IN THE ZN(II)BOUND STATE.
Descriptor:Repressor protein, ZINC ION, CHLORIDE ION
Authors:Campanello, G.C., Ma, Z., Grossoehme, N.E., Chakrovorty, D.K., Guerra, A.J., Ye, Y., Dann III, C.E., Merz Jr., K.M., Giedroc, D.P.
Deposit date:2012-08-06
Release date:2013-02-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family.
J.Mol.Biol., 425, 2013
5AGR
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
Descriptor:LEUCINE--TRNA LIGASE, METHIONINE, LEUCINE, ...
Authors:Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
Deposit date:2015-02-03
Release date:2016-03-02
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGS
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
Descriptor:LEUCYL-TRNA SYNTHETASE, METHIONINE, 3-(AMINOMETHYL)-4-BROMO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-MODIFIED ADENOSINE
Authors:Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
Deposit date:2015-02-03
Release date:2016-03-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5AGT
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CRYSTAL STRUCTURE OF THE LEURS EDITING DOMAIN OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH THE ADDUCT (S)-3-(AMINOMETHYL)-4-CHLORO-7-ETHOXYBENZO[C][1,2]OXABOROL-1(3H)-OL-AMP
Descriptor:LEUCINE--TRNA LIGASE, METHIONINE, 4-Chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[C][1,2]oxaborol-1-ol modified adenosine, ...
Authors:Palencia, A., Li, X., Alley, M.R.K., Ding, C., Easom, E.E., Hernandez, V., Meewan, M., Mohan, M., Rock, F.L., Franzblau, S.G., Wang, Y., Lenaerts, A.J., Parish, T., Cooper, C.B., Waters, M.G., Ma, Z., Mendoza, A., Barros, D., Cusack, S., Plattner, J.J.
Deposit date:2015-02-03
Release date:2016-03-02
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium Tuberculosis that Target Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
5W3D
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THE STRUCTURE OF KINESIN-14 WILD-TYPE NCD-ADP DIMER
Descriptor:Protein claret segregational, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Park, H.W., Ma, Z., Chacko, J., Jiang, S.M., Robinson, R.C., Endow, S.A.
Deposit date:2017-06-07
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
Sci Rep, 7, 2017
6Q09
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CRYSTAL STRUCTURE OF IRON-BOUND HEMERYTHRIN HHE CATION BINDING DOMAIN-CONTAINING PROTEIN: RV2633C HOMOLOG FROM MYCOBACTERIUM KANSASII
Descriptor:Hemerythrin HHE cation binding domain protein, FE (III) ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-08-01
Release date:2020-01-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of a hemerythrin-like protein from Mycobacterium kansasii and homology model of the orthologous Rv2633c protein of M. tuberculosis.
Biochem.J., 2020
6U3L
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CRYSTAL STRUCTURE OF HEMERYTHRIN HHE CATION BINDING DOMAIN-CONTAINING PROTEIN: RV2633C HOMOLOG FROM MYCOBACTERIUM KANSASII
Descriptor:Hemerythrin HHE cation binding domain protein, 1,2-ETHANEDIOL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-08-22
Release date:2020-01-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of a hemerythrin-like protein from Mycobacterium kansasii and homology model of the orthologous Rv2633c protein of M. tuberculosis.
Biochem.J., 2020
6AEJ
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CRYSTAL STRUCTURE OF HUMAN FTO IN COMPLEX WITH SMALL-MOLECULE INHIBITORS
Descriptor:Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, (E)-3-[3-nitro-4,5-bis(oxidanyl)phenyl]-2-(1,3-oxazinan-3-ylcarbonyl)prop-2-enenitrile, ZINC ION
Authors:Wang, Y., Cao, R., Peng, S., Zhang, W., Huang, N.
Deposit date:2018-08-05
Release date:2019-06-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.
Sci Transl Med, 11, 2019
6AK4
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CRYSTAL STRUCTURE OF HUMAN FTO IN COMPLEX WITH SMALL-MOLECULE INHIBITORS
Descriptor:Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION, (~{E})-2-cyano-~{N},~{N}-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide
Authors:Wang, Y., Cao, R., Peng, S., Zhang, W., Huang, N.
Deposit date:2018-08-30
Release date:2019-07-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.
Sci Transl Med, 11, 2019
3UIV
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HUMAN SERUM ALBUMIN-MYRISTATE-AMANTADINE HYDROCHLORIDE COMPLEX
Descriptor:Serum albumin, MYRISTIC ACID, (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine
Authors:Yang, F., Ma, Z., Ma, L., Yang, G.
Deposit date:2011-11-06
Release date:2012-11-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of the drug-binding specificity of human serum albumin
TO BE PUBLISHED
4M1P
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CRYSTAL STRUCTURE OF THE COPPER-SENSING REPRESSOR CSOR WITH CU(I) FROM GEOBACILLUS THERMODENITRIFICANS NG80-2
Descriptor:Copper-sensitive operon repressor (CsoR), COPPER (I) ION, SODIUM ION
Authors:Chang, F., Dann III, C.E., Giedroc, D.P.
Deposit date:2013-08-03
Release date:2014-05-21
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.564 Å)
Cite:Cu(I)-mediated allosteric switching in a copper-sensing operon repressor (CsoR).
J.Biol.Chem., 289, 2014
3QJ8
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE
Descriptor:Fatty-acid amide hydrolase 1
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-01-28
Release date:2011-04-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
3QJ9
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE INHIBITOR
Descriptor:Fatty-acid amide hydrolase 1, 1-{(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl}-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one, 1,2-ETHANEDIOL, ...
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-01-28
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
3QK5
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE INHIBITOR
Descriptor:Fatty-acid amide hydrolase 1, (3-{(3R)-1-[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]piperidin-3-yl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)acetonitrile, 1,2-ETHANEDIOL, ...
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-01-31
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
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